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Herpes simplex virus glycoproteins gH/gL and gB bind Toll-like receptor 2, and soluble gH/gL is sufficient to activate NF-κB.

Leoni V, Gianni T, Salvioli S, Campadelli-Fiume G.

J Virol. 2012 Jun;86(12):6555-62. doi: 10.1128/JVI.00295-12. Epub 2012 Apr 11.


The herpes simplex virus 1-encoded envelope glycoprotein B activates NF-κB through the Toll-like receptor 2 and MyD88/TRAF6-dependent signaling pathway.

Cai M, Li M, Wang K, Wang S, Lu Q, Yan J, Mossman KL, Lin R, Zheng C.

PLoS One. 2013;8(1):e54586. doi: 10.1371/journal.pone.0054586. Epub 2013 Jan 28.


Cross talk among the glycoproteins involved in herpes simplex virus entry and fusion: the interaction between gB and gH/gL does not necessarily require gD.

Avitabile E, Forghieri C, Campadelli-Fiume G.

J Virol. 2009 Oct;83(20):10752-60. doi: 10.1128/JVI.01287-09. Epub 2009 Aug 5.


Regulation of herpes simplex virus gB-induced cell-cell fusion by mutant forms of gH/gL in the absence of gD and cellular receptors.

Atanasiu D, Cairns TM, Whitbeck JC, Saw WT, Rao S, Eisenberg RJ, Cohen GH.

MBio. 2013 Feb 26;4(2). pii: e00046-13. doi: 10.1128/mBio.00046-13.


Characterization of Vesicular Stomatitis Virus Pseudotypes Bearing Essential Entry Glycoproteins gB, gD, gH, and gL of Herpes Simplex Virus 1.

Rogalin HB, Heldwein EE.

J Virol. 2016 Oct 28;90(22):10321-10328. doi: 10.1128/JVI.01714-16. Print 2016 Nov 15.


Dissociation of HSV gL from gH by αvβ6- or αvβ8-integrin promotes gH activation and virus entry.

Gianni T, Massaro R, Campadelli-Fiume G.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3901-10. doi: 10.1073/pnas.1506846112. Epub 2015 Jul 8.


Type I interferon and NF-κB activation elicited by herpes simplex virus gH/gL via αvβ3 integrin in epithelial and neuronal cell lines.

Gianni T, Leoni V, Campadelli-Fiume G.

J Virol. 2013 Dec;87(24):13911-6. doi: 10.1128/JVI.01894-13. Epub 2013 Oct 9.


Functional Characterization of Glycoprotein H Chimeras Composed of Conserved Domains of the Pseudorabies Virus and Herpes Simplex Virus 1 Homologs.

Böhm SW, Backovic M, Klupp BG, Rey FA, Mettenleiter TC, Fuchs W.

J Virol. 2015 Oct 21;90(1):421-32. doi: 10.1128/JVI.01985-15. Print 2016 Jan 1.


A Functional Interaction between Herpes Simplex Virus 1 Glycoprotein gH/gL Domains I and II and gD Is Defined by Using Alphaherpesvirus gH and gL Chimeras.

Fan Q, Longnecker R, Connolly SA.

J Virol. 2015 Jul;89(14):7159-69. doi: 10.1128/JVI.00740-15. Epub 2015 Apr 29.


Herpes simplex virus gD forms distinct complexes with fusion executors gB and gH/gL in part through the C-terminal profusion domain.

Gianni T, Amasio M, Campadelli-Fiume G.

J Biol Chem. 2009 Jun 26;284(26):17370-82. doi: 10.1074/jbc.M109.005728. Epub 2009 Apr 22.


Signaling pathway used by HSV-1 to induce NF-kappaB activation: possible role of herpes virus entry receptor A.

Teresa Sciortino M, Medici MA, Marino-Merlo F, Zaccaria D, Giuffrè M, Venuti A, Grelli S, Mastino A.

Ann N Y Acad Sci. 2007 Jan;1096:89-96.


Herpes simplex virus glycoproteins H/L bind to cells independently of {alpha}V{beta}3 integrin and inhibit virus entry, and their constitutive expression restricts infection.

Gianni T, Cerretani A, Dubois R, Salvioli S, Blystone SS, Rey F, Campadelli-Fiume G.

J Virol. 2010 Apr;84(8):4013-25. doi: 10.1128/JVI.02502-09. Epub 2010 Feb 10.


Cascade of events governing cell-cell fusion induced by herpes simplex virus glycoproteins gD, gH/gL, and gB.

Atanasiu D, Saw WT, Cohen GH, Eisenberg RJ.

J Virol. 2010 Dec;84(23):12292-9. doi: 10.1128/JVI.01700-10. Epub 2010 Sep 22.


Displacement of the C terminus of herpes simplex virus gD is sufficient to expose the fusion-activating interfaces on gD.

Gallagher JR, Saw WT, Atanasiu D, Lou H, Eisenberg RJ, Cohen GH.

J Virol. 2013 Dec;87(23):12656-66. doi: 10.1128/JVI.01727-13. Epub 2013 Sep 18.


Computational repositioning of ethno medicine elucidated gB-gH-gL complex as novel anti herpes drug target.

Basha SH, Talluri D, Raminni NP.

BMC Complement Altern Med. 2013 Apr 15;13:85. doi: 10.1186/1472-6882-13-85.


Involvement of HVEM receptor in activation of nuclear factor kappaB by herpes simplex virus 1 glycoprotein D.

Sciortino MT, Medici MA, Marino-Merlo F, Zaccaria D, Giuffrè-Cuculletto M, Venuti A, Grelli S, Mastino A.

Cell Microbiol. 2008 Nov;10(11):2297-311. doi: 10.1111/j.1462-5822.2008.01212.x. Epub 2008 Aug 15.


Structure-function analysis of herpes simplex virus type 1 gD and gH-gL: clues from gDgH chimeras.

Cairns TM, Milne RS, Ponce-de-Leon M, Tobin DK, Cohen GH, Eisenberg RJ.

J Virol. 2003 Jun;77(12):6731-42.

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