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Items: 1 to 20 of 101

1.

Involvement of phosphoinositide 3-kinase and PTEN protein in mechanism of activation of TRPC6 protein in vascular smooth muscle cells.

Monet M, Francoeur N, Boulay G.

J Biol Chem. 2012 May 18;287(21):17672-81. doi: 10.1074/jbc.M112.341354. Epub 2012 Apr 5.

2.

Protein kinase C-dependent phosphorylation of transient receptor potential canonical 6 (TRPC6) on serine 448 causes channel inhibition.

Bousquet SM, Monet M, Boulay G.

J Biol Chem. 2010 Dec 24;285(52):40534-43. doi: 10.1074/jbc.M110.160051. Epub 2010 Oct 20.

3.

BMP4 increases canonical transient receptor potential protein expression by activating p38 MAPK and ERK1/2 signaling pathways in pulmonary arterial smooth muscle cells.

Li X, Lu W, Fu X, Zhang Y, Yang K, Zhong N, Ran P, Wang J.

Am J Respir Cell Mol Biol. 2013 Aug;49(2):212-20. doi: 10.1165/rcmb.2012-0051OC.

4.

Calcium-sensing receptor modulates extracellular Ca(2+) entry via TRPC-encoded receptor-operated channels in human aortic smooth muscle cells.

Chow JY, Estrema C, Orneles T, Dong X, Barrett KE, Dong H.

Am J Physiol Cell Physiol. 2011 Aug;301(2):C461-8. doi: 10.1152/ajpcell.00389.2010. Epub 2011 May 11.

5.

cAMP activates TRPC6 channels via the phosphatidylinositol 3-kinase (PI3K)-protein kinase B (PKB)-mitogen-activated protein kinase kinase (MEK)-ERK1/2 signaling pathway.

Shen B, Kwan HY, Ma X, Wong CO, Du J, Huang Y, Yao X.

J Biol Chem. 2011 Jun 3;286(22):19439-45. doi: 10.1074/jbc.M110.210294. Epub 2011 Apr 12.

6.

Membrane translocation of TRPC6 channels and endothelial migration are regulated by calmodulin and PI3 kinase activation.

Chaudhuri P, Rosenbaum MA, Sinharoy P, Damron DS, Birnbaumer L, Graham LM.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2110-5. doi: 10.1073/pnas.1600371113. Epub 2016 Feb 8.

7.

Opposite regulation of KCNQ5 and TRPC6 channels contributes to vasopressin-stimulated calcium spiking responses in A7r5 vascular smooth muscle cells.

Mani BK, Brueggemann LI, Cribbs LL, Byron KL.

Cell Calcium. 2009 Apr;45(4):400-11. doi: 10.1016/j.ceca.2009.01.004. Epub 2009 Feb 25.

8.

A new role for PTEN in regulating transient receptor potential canonical channel 6-mediated Ca2+ entry, endothelial permeability, and angiogenesis.

Kini V, Chavez A, Mehta D.

J Biol Chem. 2010 Oct 22;285(43):33082-91. doi: 10.1074/jbc.M110.142034. Epub 2010 Aug 12.

9.

Nitric oxide-cGMP-protein kinase G pathway negatively regulates vascular transient receptor potential channel TRPC6.

Takahashi S, Lin H, Geshi N, Mori Y, Kawarabayashi Y, Takami N, Mori MX, Honda A, Inoue R.

J Physiol. 2008 Sep 1;586(17):4209-23. doi: 10.1113/jphysiol.2008.156083. Epub 2008 Jul 10.

10.

Upregulation of Na+/Ca2+ exchanger and TRPC6 contributes to abnormal Ca2+ homeostasis in arterial smooth muscle cells from Milan hypertensive rats.

Zulian A, Baryshnikov SG, Linde CI, Hamlyn JM, Ferrari P, Golovina VA.

Am J Physiol Heart Circ Physiol. 2010 Sep;299(3):H624-33. doi: 10.1152/ajpheart.00356.2010. Epub 2010 Jul 9.

11.

Role of endogenous TRPC6 channels in Ca2+ signal generation in A7r5 smooth muscle cells.

Soboloff J, Spassova M, Xu W, He LP, Cuesta N, Gill DL.

J Biol Chem. 2005 Dec 2;280(48):39786-94. Epub 2005 Oct 3.

12.

Activation of c-SRC underlies the differential effects of ouabain and digoxin on Ca(2+) signaling in arterial smooth muscle cells.

Zulian A, Linde CI, Pulina MV, Baryshnikov SG, Papparella I, Hamlyn JM, Golovina VA.

Am J Physiol Cell Physiol. 2013 Feb 15;304(4):C324-33. doi: 10.1152/ajpcell.00337.2012. Epub 2012 Nov 28.

13.

Reactive oxygen species-mediated TRPC6 protein activation in vascular myocytes, a mechanism for vasoconstrictor-regulated vascular tone.

Ding Y, Winters A, Ding M, Graham S, Akopova I, Muallem S, Wang Y, Hong JH, Gryczynski Z, Yang SH, Birnbaumer L, Ma R.

J Biol Chem. 2011 Sep 9;286(36):31799-809. doi: 10.1074/jbc.M111.248344. Epub 2011 Jul 15.

14.

Heteromultimeric TRPC6-TRPC7 channels contribute to arginine vasopressin-induced cation current of A7r5 vascular smooth muscle cells.

Maruyama Y, Nakanishi Y, Walsh EJ, Wilson DP, Welsh DG, Cole WC.

Circ Res. 2006 Jun 23;98(12):1520-7. Epub 2006 May 11.

15.

Molecular determinants for cardiovascular TRPC6 channel regulation by Ca2+/calmodulin-dependent kinase II.

Shi J, Geshi N, Takahashi S, Kiyonaka S, Ichikawa J, Hu Y, Mori Y, Ito Y, Inoue R.

J Physiol. 2013 Jun 1;591(11):2851-66. doi: 10.1113/jphysiol.2013.251249. Epub 2013 Mar 25.

16.

Unique, highly proliferative growth phenotype expressed by embryonic and neointimal smooth muscle cells is driven by constitutive Akt, mTOR, and p70S6K signaling and is actively repressed by PTEN.

Mourani PM, Garl PJ, Wenzlau JM, Carpenter TC, Stenmark KR, Weiser-Evans MC.

Circulation. 2004 Mar 16;109(10):1299-306. Epub 2004 Mar 1.

17.

High glucose enhances transient receptor potential channel canonical type 6-dependent calcium influx in human platelets via phosphatidylinositol 3-kinase-dependent pathway.

Liu D, Maier A, Scholze A, Rauch U, Boltzen U, Zhao Z, Zhu Z, Tepel M.

Arterioscler Thromb Vasc Biol. 2008 Apr;28(4):746-51. doi: 10.1161/ATVBAHA.108.162222. Epub 2008 Feb 7.

18.

Post-transcriptional silencing of TRPC1 ion channel gene by RNA interference upregulates TRPC6 expression and store-operated Ca2+ entry in A7r5 vascular smooth muscle cells.

Selli C, Erac Y, Kosova B, Tosun M.

Vascul Pharmacol. 2009 Aug-Sep;51(2-3):96-100. doi: 10.1016/j.vph.2009.04.001. Epub 2009 Apr 20.

PMID:
19386284
19.

Adenylate cyclase/cAMP/protein kinase A signaling pathway inhibits endothelin type A receptor-operated Ca²⁺ entry mediated via transient receptor potential canonical 6 channels.

Horinouchi T, Higa T, Aoyagi H, Nishiya T, Terada K, Miwa S.

J Pharmacol Exp Ther. 2012 Jan;340(1):143-51. doi: 10.1124/jpet.111.187500. Epub 2011 Oct 14.

20.

Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo.

Tsvilovskyy VV, Zholos AV, Aberle T, Philipp SE, Dietrich A, Zhu MX, Birnbaumer L, Freichel M, Flockerzi V.

Gastroenterology. 2009 Oct;137(4):1415-24. doi: 10.1053/j.gastro.2009.06.046. Epub 2009 Jun 21.

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