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Items: 1 to 20 of 135

1.

Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver.

Satapati S, Sunny NE, Kucejova B, Fu X, He TT, Méndez-Lucas A, Shelton JM, Perales JC, Browning JD, Burgess SC.

J Lipid Res. 2012 Jun;53(6):1080-92. doi: 10.1194/jlr.M023382. Epub 2012 Apr 9.

2.

Lipotoxicity in steatohepatitis occurs despite an increase in tricarboxylic acid cycle activity.

Patterson RE, Kalavalapalli S, Williams CM, Nautiyal M, Mathew JT, Martinez J, Reinhard MK, McDougall DJ, Rocca JR, Yost RA, Cusi K, Garrett TJ, Sunny NE.

Am J Physiol Endocrinol Metab. 2016 Apr 1;310(7):E484-94. doi: 10.1152/ajpendo.00492.2015. Epub 2016 Jan 26.

3.

Inhibition of Pyruvate Dehydrogenase Kinase 2 Protects Against Hepatic Steatosis Through Modulation of Tricarboxylic Acid Cycle Anaplerosis and Ketogenesis.

Go Y, Jeong JY, Jeoung NH, Jeon JH, Park BY, Kang HJ, Ha CM, Choi YK, Lee SJ, Ham HJ, Kim BG, Park KG, Park SY, Lee CH, Choi CS, Park TS, Lee WN, Harris RA, Lee IK.

Diabetes. 2016 Oct;65(10):2876-87. doi: 10.2337/db16-0223. Epub 2016 Jul 6.

4.

Cross-talk between branched-chain amino acids and hepatic mitochondria is compromised in nonalcoholic fatty liver disease.

Sunny NE, Kalavalapalli S, Bril F, Garrett TJ, Nautiyal M, Mathew JT, Williams CM, Cusi K.

Am J Physiol Endocrinol Metab. 2015 Aug 15;309(4):E311-9. doi: 10.1152/ajpendo.00161.2015. Epub 2015 Jun 9.

5.

Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease.

Sunny NE, Parks EJ, Browning JD, Burgess SC.

Cell Metab. 2011 Dec 7;14(6):804-10. doi: 10.1016/j.cmet.2011.11.004.

6.

Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism.

Satapati S, He T, Inagaki T, Potthoff M, Merritt ME, Esser V, Mangelsdorf DJ, Kliewer SA, Browning JD, Burgess SC.

Diabetes. 2008 Aug;57(8):2012-21. doi: 10.2337/db08-0226. Epub 2008 May 9.

7.

Allyl isothiocyanate ameliorates insulin resistance through the regulation of mitochondrial function.

Ahn J, Lee H, Im SW, Jung CH, Ha TY.

J Nutr Biochem. 2014 Oct;25(10):1026-34. doi: 10.1016/j.jnutbio.2014.05.006. Epub 2014 Jun 5.

PMID:
25034503
8.

Aerobic capacity and hepatic mitochondrial lipid oxidation alters susceptibility for chronic high-fat diet-induced hepatic steatosis.

Morris EM, Meers GM, Koch LG, Britton SL, Fletcher JA, Fu X, Shankar K, Burgess SC, Ibdah JA, Rector RS, Thyfault JP.

Am J Physiol Endocrinol Metab. 2016 Oct 1;311(4):E749-E760. doi: 10.1152/ajpendo.00178.2016. Epub 2016 Sep 6.

PMID:
27600823
9.

Regulation of hepatic fat and glucose oxidation in rats with lipid-induced hepatic insulin resistance.

Alves TC, Befroy DE, Kibbey RG, Kahn M, Codella R, Carvalho RA, Falk Petersen K, Shulman GI.

Hepatology. 2011 Apr;53(4):1175-81. doi: 10.1002/hep.24170. Epub 2011 Mar 11.

10.

Activity-based protein profiling reveals mitochondrial oxidative enzyme impairment and restoration in diet-induced obese mice.

Sadler NC, Angel TE, Lewis MP, Pederson LM, Chauvigné-Hines LM, Wiedner SD, Zink EM, Smith RD, Wright AT.

PLoS One. 2012;7(10):e47996. doi: 10.1371/journal.pone.0047996. Epub 2012 Oct 24.

11.

Exenatide improves liver mitochondrial dysfunction and insulin resistance by reducing oxidative stress in high fat diet-induced obese mice.

Wang Z, Hou L, Huang L, Guo J, Zhou X.

Biochem Biophys Res Commun. 2017 Apr 22;486(1):116-123. doi: 10.1016/j.bbrc.2017.03.010. Epub 2017 Mar 6.

PMID:
28274877
12.

β-catenin links hepatic metabolic zonation with lipid metabolism and diet-induced obesity in mice.

Behari J, Li H, Liu S, Stefanovic-Racic M, Alonso L, O'Donnell CP, Shiva S, Singamsetty S, Watanabe Y, Singh VP, Liu Q.

Am J Pathol. 2014 Dec;184(12):3284-98. doi: 10.1016/j.ajpath.2014.08.022. Epub 2014 Oct 7.

13.

Impact of peripheral ketolytic deficiency on hepatic ketogenesis and gluconeogenesis during the transition to birth.

Cotter DG, Ercal B, d'Avignon DA, Dietzen DJ, Crawford PA.

J Biol Chem. 2013 Jul 5;288(27):19739-49. doi: 10.1074/jbc.M113.454868. Epub 2013 May 20.

14.

High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial function in vivo.

Mantena SK, Vaughn DP, Andringa KK, Eccleston HB, King AL, Abrams GA, Doeller JE, Kraus DW, Darley-Usmar VM, Bailey SM.

Biochem J. 2009 Jan 1;417(1):183-93. doi: 10.1042/BJ20080868.

15.

Liver adapts mitochondrial function to insulin resistant and diabetic states in mice.

Franko A, von Kleist-Retzow JC, Neschen S, Wu M, Schommers P, Böse M, Kunze A, Hartmann U, Sanchez-Lasheras C, Stoehr O, Huntgeburth M, Brodesser S, Irmler M, Beckers J, de Angelis MH, Paulsson M, Schubert M, Wiesner RJ.

J Hepatol. 2014 Apr;60(4):816-23. doi: 10.1016/j.jhep.2013.11.020. Epub 2013 Nov 28.

PMID:
24291365
16.

Bitter gourd inhibits the development of obesity-associated fatty liver in C57BL/6 mice fed a high-fat diet.

Xu J, Cao K, Li Y, Zou X, Chen C, Szeto IM, Dong Z, Zhao Y, Shi Y, Wang J, Liu J, Feng Z.

J Nutr. 2014 Apr;144(4):475-83. doi: 10.3945/jn.113.187450. Epub 2014 Feb 12.

17.

A small amount of dietary carbohydrate can promote the HFD-induced insulin resistance to a maximal level.

Mei S, Yang X, Guo H, Gu H, Zha L, Cai J, Li X, Liu Z, Bennett BJ, He L, Cao W.

PLoS One. 2014 Jul 23;9(7):e100875. doi: 10.1371/journal.pone.0100875. eCollection 2014.

18.

Synthetic FXR agonist GW4064 prevents diet-induced hepatic steatosis and insulin resistance.

Ma Y, Huang Y, Yan L, Gao M, Liu D.

Pharm Res. 2013 May;30(5):1447-57. doi: 10.1007/s11095-013-0986-7. Epub 2013 Feb 1.

19.

8-Oxoguanine DNA glycosylase (OGG1) deficiency increases susceptibility to obesity and metabolic dysfunction.

Sampath H, Vartanian V, Rollins MR, Sakumi K, Nakabeppu Y, Lloyd RS.

PLoS One. 2012;7(12):e51697. doi: 10.1371/journal.pone.0051697. Epub 2012 Dec 17.

20.

Acetyl-L-carnitine and lipoic acid improve mitochondrial abnormalities and serum levels of liver enzymes in a mouse model of nonalcoholic fatty liver disease.

Kathirvel E, Morgan K, French SW, Morgan TR.

Nutr Res. 2013 Nov;33(11):932-41. doi: 10.1016/j.nutres.2013.08.001. Epub 2013 Sep 18.

PMID:
24176233

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