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Items: 1 to 20 of 55

1.

LIMK2 is a crucial regulator and effector of Aurora-A-kinase-mediated malignancy.

Johnson EO, Chang KH, Ghosh S, Venkatesh C, Giger K, Low PS, Shah K.

J Cell Sci. 2012 Mar 1;125(Pt 5):1204-16. doi: 10.1242/jcs.092304.

2.

PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer.

Johnson EO, Chang KH, de Pablo Y, Ghosh S, Mehta R, Badve S, Shah K.

J Cell Sci. 2011 Aug 15;124(Pt 16):2711-22. doi: 10.1242/jcs.084970.

3.

Adenovirus-mediated Aurora A shRNA driven by stathmin promoter suppressed tumor growth and enhanced paclitaxel chemotherapy sensitivity in human breast carcinoma cells.

Long M, Yin G, Liu L, Lin F, Wang X, Ren J, Wei J, Dong K, Zhang H.

Cancer Gene Ther. 2012 Apr;19(4):271-81. doi: 10.1038/cgt.2011.89. Epub 2012 Jan 27.

PMID:
22281755
4.

Aurora B confers cancer cell resistance to TRAIL-induced apoptosis via phosphorylation of survivin.

Yoon MJ, Park SS, Kang YJ, Kim IY, Lee JA, Lee JS, Kim EG, Lee CW, Choi KS.

Carcinogenesis. 2012 Mar;33(3):492-500. doi: 10.1093/carcin/bgr298. Epub 2011 Dec 9.

PMID:
22159225
5.

LIM-kinase 2, a regulator of actin dynamics, is involved in mitotic spindle integrity and sensitivity to microtubule-destabilizing drugs.

Po'uha ST, Shum MS, Goebel A, Bernard O, Kavallaris M.

Oncogene. 2010 Jan 28;29(4):597-607. doi: 10.1038/onc.2009.367. Epub 2009 Nov 2.

PMID:
19881550
6.

Aurora-A kinase phosphorylation of Aurora-A kinase interacting protein (AIP) and stabilization of the enzyme-substrate complex.

Katayama H, Sasai K, Czerniak BA, Carter JL, Sen S.

J Cell Biochem. 2007 Dec 1;102(5):1318-31.

PMID:
17957726
7.
8.

Functional significance of Aurora kinase A regulatory interactions with p53-ERĪ± complex in human breast cancer cells.

Katayama H, Sen S.

Horm Cancer. 2011 Apr;2(2):117-24. doi: 10.1007/s12672-011-0070-x.

PMID:
21761334
9.

Investigating the role of Aurora kinases in RAS signaling.

Kosik A, Bekier ME, Katusin JD, Kaur H, Zhou X, Diakonova M, Chadee DN, Taylor WR.

J Cell Biochem. 2009 Jan 1;106(1):33-41. doi: 10.1002/jcb.21974.

PMID:
19009561
10.

Aurora-A kinase regulates NF-kappaB activity: lessons from combination studies.

Linardopoulos S.

J BUON. 2007 Sep;12 Suppl 1:S67-70.

PMID:
17935280
11.

Impaired spermatogenic ability of testicular germ cells in mice deficient in the LIM-kinase 2 gene.

Takahashi H, Koshimizu U, Miyazaki J, Nakamura T.

Dev Biol. 2002 Jan 15;241(2):259-72.

12.

The mitotic kinase Aurora-A induces mammary cell migration and breast cancer metastasis by activating the Cofilin-F-actin pathway.

Wang LH, Xiang J, Yan M, Zhang Y, Zhao Y, Yue CF, Xu J, Zheng FM, Chen JN, Kang Z, Chen TS, Xing D, Liu Q.

Cancer Res. 2010 Nov 15;70(22):9118-28. doi: 10.1158/0008-5472.CAN-10-1246. Epub 2010 Nov 2.

13.

LIM kinases are attractive targets with many macromolecular partners and only a few small molecule regulators.

Manetti F.

Med Res Rev. 2012 Sep;32(5):968-98. doi: 10.1002/med.20230. Epub 2011 Jan 16. Review.

PMID:
22886629
14.

Oncogenic role of nuclear accumulated Aurora-A.

Tatsuka M, Sato S, Kanda A, Miki T, Kamata N, Kitajima S, Kudo Y, Takata T.

Mol Carcinog. 2009 Sep;48(9):810-20. doi: 10.1002/mc.20525.

PMID:
19204928
15.

Preclinical evaluation of AMG 900, a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines.

Payton M, Bush TL, Chung G, Ziegler B, Eden P, McElroy P, Ross S, Cee VJ, Deak HL, Hodous BL, Nguyen HN, Olivieri PR, Romero K, Schenkel LB, Bak A, Stanton M, Dussault I, Patel VF, Geuns-Meyer S, Radinsky R, Kendall RL.

Cancer Res. 2010 Dec 1;70(23):9846-54. doi: 10.1158/0008-5472.CAN-10-3001. Epub 2010 Oct 8.

16.

MLN8054, an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo.

Huck JJ, Zhang M, McDonald A, Bowman D, Hoar KM, Stringer B, Ecsedy J, Manfredi MG, Hyer ML.

Mol Cancer Res. 2010 Mar;8(3):373-84. doi: 10.1158/1541-7786.MCR-09-0300. Epub 2010 Mar 2.

17.

Small interfering RNA targeting integrin-linked kinase inhibited the growth and induced apoptosis in human bladder cancer cells.

Gao J, Zhu J, Li HY, Pan XY, Jiang R, Chen JX.

Int J Biochem Cell Biol. 2011 Sep;43(9):1294-304. doi: 10.1016/j.biocel.2011.05.003. Epub 2011 May 11.

PMID:
21601006
18.

Effects of DNAzymes targeting Aurora kinase A on the growth of human prostate cancer.

Qu Y, Zhang L, Mao M, Zhao F, Huang X, Yang C, Xiong Y, Mu D.

Cancer Gene Ther. 2008 Aug;15(8):517-25. doi: 10.1038/cgt.2008.22. Epub 2008 Apr 11.

PMID:
18404163
20.

Small-molecule inhibition of Aurora kinases triggers spindle checkpoint-independent apoptosis in cancer cells.

Sun L, Li D, Dong X, Yu H, Dong JT, Zhang C, Lu X, Zhou J.

Biochem Pharmacol. 2008 Mar 1;75(5):1027-34. doi: 10.1016/j.bcp.2007.11.007. Epub 2007 Nov 22.

PMID:
18163976

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