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Items: 1 to 20 of 123

1.

Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes.

Rosengren AH, Braun M, Mahdi T, Andersson SA, Travers ME, Shigeto M, Zhang E, Almgren P, Ladenvall C, Axelsson AS, Edlund A, Pedersen MG, Jonsson A, Ramracheya R, Tang Y, Walker JN, Barrett A, Johnson PR, Lyssenko V, McCarthy MI, Groop L, Salehi A, Gloyn AL, Renström E, Rorsman P, Eliasson L.

Diabetes. 2012 Jul;61(7):1726-33. doi: 10.2337/db11-1516. Epub 2012 Apr 9.

2.

Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes.

Rosengren AH, Jokubka R, Tojjar D, Granhall C, Hansson O, Li DQ, Nagaraj V, Reinbothe TM, Tuncel J, Eliasson L, Groop L, Rorsman P, Salehi A, Lyssenko V, Luthman H, Renström E.

Science. 2010 Jan 8;327(5962):217-20. doi: 10.1126/science.1176827. Epub 2009 Nov 19.

3.

Genetic risk score constructed using 14 susceptibility alleles for type 2 diabetes is associated with the early onset of diabetes and may predict the future requirement of insulin injections among Japanese individuals.

Iwata M, Maeda S, Kamura Y, Takano A, Kato H, Murakami S, Higuchi K, Takahashi A, Fujita H, Hara K, Kadowaki T, Tobe K.

Diabetes Care. 2012 Aug;35(8):1763-70. doi: 10.2337/dc11-2006. Epub 2012 Jun 11.

4.

Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function.

Pascoe L, Tura A, Patel SK, Ibrahim IM, Ferrannini E, Zeggini E, Weedon MN, Mari A, Hattersley AT, McCarthy MI, Frayling TM, Walker M; RISC Consortium; U.K. Type 2 Diabetes Genetics Consortium.

Diabetes. 2007 Dec;56(12):3101-4. Epub 2007 Sep 5.

5.

Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion.

Dayeh T, Volkov P, Salö S, Hall E, Nilsson E, Olsson AH, Kirkpatrick CL, Wollheim CB, Eliasson L, Rönn T, Bacos K, Ling C.

PLoS Genet. 2014 Mar 6;10(3):e1004160. doi: 10.1371/journal.pgen.1004160. eCollection 2014 Mar.

6.

Genetic variations in the pancreatic ATP-sensitive potassium channel, beta-cell dysfunction, and susceptibility to type 2 diabetes.

Chistiakov DA, Potapov VA, Khodirev DC, Shamkhalova MS, Shestakova MV, Nosikov VV.

Acta Diabetol. 2009 Mar;46(1):43-9. doi: 10.1007/s00592-008-0056-5. Epub 2008 Aug 29.

PMID:
18758683
7.

Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men.

Vangipurapu J, Stančáková A, Pihlajamäki J, Kuulasmaa TM, Kuulasmaa T, Paananen J, Kuusisto J, Ferrannini E, Laakso M.

Diabetologia. 2011 Mar;54(3):563-71. doi: 10.1007/s00125-010-1977-4. Epub 2010 Dec 12.

PMID:
21153532
8.

KCNJ11, ABCC8 and TCF7L2 polymorphisms and the response to sulfonylurea treatment in patients with type 2 diabetes: a bioinformatics assessment.

Song J, Yang Y, Mauvais-Jarvis F, Wang YP, Niu T.

BMC Med Genet. 2017 Jun 6;18(1):64. doi: 10.1186/s12881-017-0422-7.

10.

Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies.

Grarup N, Rose CS, Andersson EA, Andersen G, Nielsen AL, Albrechtsen A, Clausen JO, Rasmussen SS, Jørgensen T, Sandbaek A, Lauritzen T, Schmitz O, Hansen T, Pedersen O.

Diabetes. 2007 Dec;56(12):3105-11. Epub 2007 Sep 7.

11.

TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells.

da Silva Xavier G, Loder MK, McDonald A, Tarasov AI, Carzaniga R, Kronenberger K, Barg S, Rutter GA.

Diabetes. 2009 Apr;58(4):894-905. doi: 10.2337/db08-1187. Epub 2009 Jan 23.

12.

Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people.

Boesgaard TW, Grarup N, Jørgensen T, Borch-Johnsen K; Meta-Analysis of Glucose and Insulin-Related Trait Consortium (MAGIC), Hansen T, Pedersen O.

Diabetologia. 2010 Aug;53(8):1647-55. doi: 10.1007/s00125-010-1753-5. Epub 2010 Apr 26.

PMID:
20419449
13.

Separately inherited defects in insulin exocytosis and beta-cell glucose metabolism contribute to type 2 diabetes.

Granhall C, Rosengren AH, Renström E, Luthman H.

Diabetes. 2006 Dec;55(12):3494-500.

14.

Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction.

Fu J, Dai X, Plummer G, Suzuki K, Bautista A, Githaka JM, Senior L, Jensen M, Greitzer-Antes D, Manning Fox JE, Gaisano HY, Newgard CB, Touret N, MacDonald PE.

Diabetes. 2017 Jul;66(7):1890-1900. doi: 10.2337/db16-1170. Epub 2017 Jun 12.

PMID:
28607108
15.

Impact of common type 2 diabetes risk gene variants on future type 2 diabetes in the non-diabetic population in Korea.

Park SE, Lee WY, Oh KW, Baek KH, Yoon KH, Kang MI, Son HY, Lee WC.

J Hum Genet. 2012 Apr;57(4):265-8. doi: 10.1038/jhg.2012.16. Epub 2012 Mar 1.

PMID:
22377714
16.

TCF7L2 is a master regulator of insulin production and processing.

Zhou Y, Park SY, Su J, Bailey K, Ottosson-Laakso E, Shcherbina L, Oskolkov N, Zhang E, Thevenin T, Fadista J, Bennet H, Vikman P, Wierup N, Fex M, Rung J, Wollheim C, Nobrega M, Renström E, Groop L, Hansson O.

Hum Mol Genet. 2014 Dec 15;23(24):6419-31. doi: 10.1093/hmg/ddu359. Epub 2014 Jul 11.

17.

A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion.

Jonsson A, Isomaa B, Tuomi T, Taneera J, Salehi A, Nilsson P, Groop L, Lyssenko V.

Diabetes. 2009 Oct;58(10):2409-13. doi: 10.2337/db09-0246. Epub 2009 Jul 7.

18.

Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion.

Heni M, Ketterer C, Thamer C, Herzberg-Schäfer SA, Guthoff M, Stefan N, Machicao F, Staiger H, Fritsche A, Häring HU.

Diabetes. 2010 Dec;59(12):3247-52. doi: 10.2337/db10-0674. Epub 2010 Aug 29.

19.

Identification of ABCC8 as a contributory gene to impaired early-phase insulin secretion in NZO mice.

Andrikopoulos S, Fam BC, Holdsworth A, Visinoni S, Ruan Z, Stathopoulos M, Thorburn AW, Joannides CN, Cancilla M, Balmer L, Proietto J, Morahan G.

J Endocrinol. 2016 Jan;228(1):61-73. doi: 10.1530/JOE-15-0290. Epub 2015 Oct 22.

20.

Physical activity modifies the effect of SNPs in the SLC2A2 (GLUT2) and ABCC8 (SUR1) genes on the risk of developing type 2 diabetes.

Kilpeläinen TO, Lakka TA, Laaksonen DE, Laukkanen O, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Aunola S, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M; Finnish Diabetes Prevention Study Group.

Physiol Genomics. 2007 Oct 22;31(2):264-72. Epub 2007 Jul 17. Erratum in: Physiol Genomics. 2008 Feb 19;32(3):419.

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