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Improvement of psoriasis after tonsillectomy is associated with a decrease in the frequency of circulating T cells that recognize streptococcal determinants and homologous skin determinants.

Thorleifsdottir RH, Sigurdardottir SL, Sigurgeirsson B, Olafsson JH, Sigurdsson MI, Petersen H, Arnadottir S, Gudjonsson JE, Johnston A, Valdimarsson H.

J Immunol. 2012 May 15;188(10):5160-5. doi: 10.4049/jimmunol.1102834. Epub 2012 Apr 9.


Identical TCR beta-chain rearrangements in streptococcal angina and skin lesions of patients with psoriasis vulgaris.

Diluvio L, Vollmer S, Besgen P, Ellwart JW, Chimenti S, Prinz JC.

J Immunol. 2006 Jun 1;176(11):7104-11.


Psoriasis--as an autoimmune disease caused by molecular mimicry.

Valdimarsson H, Thorleifsdottir RH, Sigurdardottir SL, Gudjonsson JE, Johnston A.

Trends Immunol. 2009 Oct;30(10):494-501. doi: 10.1016/ Epub 2009 Sep 24. Review.


Tonsillectomy as a treatment for psoriasis: a review.

Wu W, Debbaneh M, Moslehi H, Koo J, Liao W.

J Dermatolog Treat. 2014 Dec;25(6):482-6. doi: 10.3109/09546634.2013.848258. Epub 2013 Nov 27. Review.


The association of sore throat and psoriasis might be explained by histologically distinctive tonsils and increased expression of skin-homing molecules by tonsil T cells.

Sigurdardottir SL, Thorleifsdottir RH, Valdimarsson H, Johnston A.

Clin Exp Immunol. 2013 Oct;174(1):139-51. doi: 10.1111/cei.12153.


Is psoriasis induced by streptococcal superantigens and maintained by M-protein-specific T cells that cross-react with keratin?

Valdimarsson H, Sigmundsdóttir H, Jónsdóttir I.

Clin Exp Immunol. 1997 Jan;107 Suppl 1:21-4. Review.


Circulating T cells of patients with active psoriasis respond to streptococcal M-peptides sharing sequences with human epidermal keratins.

Sigmundsdottir H, Sigurgeirsson B, Troye-Blomberg M, Good MF, Valdimarsson H, Jonsdottir I.

Scand J Immunol. 1997 Jun;45(6):688-97.


Is an epitope on keratin 17 a major target for autoreactive T lymphocytes in psoriasis?

Gudmundsdottir AS, Sigmundsdottir H, Sigurgeirsson B, Good MF, Valdimarsson H, Jonsdottir I.

Clin Exp Immunol. 1999 Sep;117(3):580-6.


CD4+ T-cells from peripheral blood of a patient with psoriasis recognize keratin 14 peptide but not 'homologous' streptococcal M-protein epitope.

Kobayashi H, Takahashi M, Takahashi H, Ishida-Yamamoto A, Hashimoto Y, Sato K, Tateno M, Iizuka H.

J Dermatol Sci. 2002 Dec;30(3):240-7.


Presence of keratin-specific antibody-forming cells in palatine tonsils of patients with pustulosis palmaris et plantaris (PPP) and its correlation with prognosis after tonsillectomy.

Tanimoto Y, Fukuyama S, Tanaka N, Ohori J, Tanimoto Y, Kurono Y.

Acta Otolaryngol. 2014 Jan;134(1):79-87. doi: 10.3109/00016489.2013.831477. Epub 2013 Oct 21.


The role of the palatine tonsils in the pathogenesis and treatment of psoriasis.

Sigurdardottir SL, Thorleifsdottir RH, Valdimarsson H, Johnston A.

Br J Dermatol. 2013 Feb;168(2):237-42. doi: 10.1111/j.1365-2133.2012.11215.x. Epub 2012 Dec 13. Review.


Up-regulation of CC chemokine receptor 6 on tonsillar T cells and its induction by in vitro stimulation with alpha-streptococci in patients with pustulosis palmaris et plantaris.

Yoshizaki T, Bandoh N, Ueda S, Nozawa H, Goto T, Kishibe K, Takahara M, Harabuchi Y.

Clin Exp Immunol. 2009 Jul;157(1):71-82. doi: 10.1111/j.1365-2249.2009.03945.x.


Skin T cell proliferative response to M protein and other cell wall and membrane proteins of group A streptococci in chronic plaque psoriasis.

Baker BS, Brown DW, Fischetti VA, Ovigne JM, Porter W, Powles A, Fry L.

Clin Exp Immunol. 2001 Jun;124(3):516-21.


[Efficacy of tonsillectomy on psoriasis and tonsil histology].

Takahara M, Bandoh N, Imada M, Hayashi T, Nonaka S, Harabuchi Y.

Nihon Jibiinkoka Gakkai Kaiho. 2001 Nov;104(11):1065-70. Japanese.


Clinical outcome of tonsillectomy for palmoplantar pustulosis and etiological relationship between palmoplantar pustulosis and tonsils.

Takahara M.

Adv Otorhinolaryngol. 2011;72:86-8. doi: 10.1159/000324618. Epub 2011 Aug 18. Review.


Antigen-independent expansion of T cells from psoriatic skin lesions: phenotypic characterization and antigen reactivity.

Horrocks C, Holder JE, Berth-Jones J, Camp RD.

Br J Dermatol. 1997 Sep;137(3):331-8.


Streptococcal throat infections and exacerbation of chronic plaque psoriasis: a prospective study.

Gudjonsson JE, Thorarinsson AM, Sigurgeirsson B, Kristinsson KG, Valdimarsson H.

Br J Dermatol. 2003 Sep;149(3):530-4.


Novel insight into the agonistic mechanism of alefacept in vivo: differentially expressed genes may serve as biomarkers of response in psoriasis patients.

Haider AS, Lowes MA, Gardner H, Bandaru R, Darabi K, Chamian F, Kikuchi T, Gilleaudeau P, Whalen MS, Cardinale I, Novitskaya I, Krueger JG.

J Immunol. 2007 Jun 1;178(11):7442-9.

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