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Items: 1 to 20 of 111

1.

Computational identification and modeling of crosstalk between phosphorylation, O-β-glycosylation and methylation of FoxO3 and implications for cancer therapeutics.

Butt AM, Feng D, Idrees M, Tong Y, Lu J.

Int J Mol Sci. 2012;13(3):2918-38. doi: 10.3390/ijms13032918. Epub 2012 Mar 5.

2.

Computational identification of interplay between phosphorylation and O-β-glycosylation of human occludin as potential mechanism to impair hepatitis C virus entry.

Butt AM, Feng D, Nasrullah I, Tahir S, Idrees M, Tong Y, Lu J.

Infect Genet Evol. 2012 Aug;12(6):1235-45. doi: 10.1016/j.meegid.2012.04.001. Epub 2012 Apr 10.

PMID:
22516225
3.

Regulation of FOXO3 by phosphorylation and methylation in hepatitis C virus infection and alcohol exposure.

Tikhanovich I, Kuravi S, Campbell RV, Kharbanda KK, Artigues A, Villar MT, Weinman SA.

Hepatology. 2014 Jan;59(1):58-70. doi: 10.1002/hep.26618. Epub 2013 Nov 20.

4.

Lysine methylation of FOXO3 regulates oxidative stress-induced neuronal cell death.

Xie Q, Hao Y, Tao L, Peng S, Rao C, Chen H, You H, Dong MQ, Yuan Z.

EMBO Rep. 2012 Apr;13(4):371-7. doi: 10.1038/embor.2012.25.

5.

Role of post translational modifications and novel crosstalk between phosphorylation and O-beta-GlcNAc modifications in human claudin-1, -3 and -4.

Butt AM, Khan IB, Hussain M, Idress M, Lu J, Tong Y.

Mol Biol Rep. 2012 Feb;39(2):1359-69. doi: 10.1007/s11033-011-0870-7. Epub 2011 May 27.

PMID:
21617949
6.

Posttranslational modifications control FoxO3 activity during denervation.

Bertaggia E, Coletto L, Sandri M.

Am J Physiol Cell Physiol. 2012 Feb 1;302(3):C587-96. doi: 10.1152/ajpcell.00142.2011. Epub 2011 Nov 16.

7.

FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics.

Jacobs FM, van der Heide LP, Wijchers PJ, Burbach JP, Hoekman MF, Smidt MP.

J Biol Chem. 2003 Sep 19;278(38):35959-67. Epub 2003 Jul 11.

8.

Epidermal growth factor receptors: function modulation by phosphorylation and glycosylation interplay.

Kaleem A, Ahmad I, Hoessli DC, Walker-Nasir E, Saleem M, Shakoori AR, Nasir-Ud-Din.

Mol Biol Rep. 2009 Apr;36(4):631-9. doi: 10.1007/s11033-008-9223-6. Epub 2008 Mar 14.

PMID:
18340549
9.

Methylation by Set9 modulates FoxO3 stability and transcriptional activity.

Calnan DR, Webb AE, White JL, Stowe TR, Goswami T, Shi X, Espejo A, Bedford MT, Gozani O, Gygi SP, Brunet A.

Aging (Albany NY). 2012 Jul;4(7):462-79.

10.

LKB1 downregulation may be independent of promoter methylation or FOXO3 expression in head and neck cancer.

Ekizoglu S, Dalay N, Karaman E, Akdeniz D, Ozaydin A, Buyru N.

Transl Res. 2013 Aug;162(2):122-9. doi: 10.1016/j.trsl.2013.06.001. Epub 2013 Jun 25.

PMID:
23810581
11.

The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor.

Greer EL, Oskoui PR, Banko MR, Maniar JM, Gygi MP, Gygi SP, Brunet A.

J Biol Chem. 2007 Oct 12;282(41):30107-19. Epub 2007 Aug 20.

12.

FOXO3/FKHRL1 is activated by 5-aza-2-deoxycytidine and induces silenced caspase-8 in neuroblastoma.

Geiger K, Hagenbuchner J, Rupp M, Fiegl H, Sergi C, Meister B, Kiechl-Kohlendorfer U, Müller T, Ausserlechner MJ, Obexer P.

Mol Biol Cell. 2012 Jun;23(11):2226-34. doi: 10.1091/mbc.E11-06-0535. Epub 2012 Apr 4.

14.
15.

Bimodal regulation of FoxO3 by AKT and 14-3-3.

Dobson M, Ramakrishnan G, Ma S, Kaplun L, Balan V, Fridman R, Tzivion G.

Biochim Biophys Acta. 2011 Aug;1813(8):1453-64. doi: 10.1016/j.bbamcr.2011.05.001. Epub 2011 May 19.

16.

FOXO3 is a glucocorticoid receptor target and regulates LKB1 and its own expression based on cellular AMP levels via a positive autoregulatory loop.

Lützner N, Kalbacher H, Krones-Herzig A, Rösl F.

PLoS One. 2012;7(7):e42166. doi: 10.1371/journal.pone.0042166. Epub 2012 Jul 27.

17.

E2F transcription factor 1 regulates cellular and organismal senescence by inhibiting Forkhead box O transcription factors.

Xie Q, Peng S, Tao L, Ruan H, Yang Y, Li TM, Adams U, Meng S, Bi X, Dong MQ, Yuan Z.

J Biol Chem. 2014 Dec 5;289(49):34205-13. doi: 10.1074/jbc.M114.587170. Epub 2014 Oct 24.

18.

Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation.

Wang F, Chan CH, Chen K, Guan X, Lin HK, Tong Q.

Oncogene. 2012 Mar 22;31(12):1546-57. doi: 10.1038/onc.2011.347. Epub 2011 Aug 15.

PMID:
21841822
19.

FOXO3 is inhibited by oncogenic PI3K/Akt signaling but can be reactivated by the NSAID sulindac sulfide.

Weidinger C, Krause K, Mueller K, Klagge A, Fuhrer D.

J Clin Endocrinol Metab. 2011 Sep;96(9):E1361-71. doi: 10.1210/jc.2010-2453. Epub 2011 Jul 13.

PMID:
21752881
20.

Inhibition of FOXO3 tumor suppressor function by betaTrCP1 through ubiquitin-mediated degradation in a tumor mouse model.

Tsai WB, Chung YM, Zou Y, Park SH, Xu Z, Nakayama K, Lin SH, Hu MC.

PLoS One. 2010 Jul 2;5(7):e11171. doi: 10.1371/journal.pone.0011171.

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