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Items: 1 to 20 of 101

1.

Design of the novel protraction mechanism of insulin degludec, an ultra-long-acting basal insulin.

Jonassen I, Havelund S, Hoeg-Jensen T, Steensgaard DB, Wahlund PO, Ribel U.

Pharm Res. 2012 Aug;29(8):2104-14. doi: 10.1007/s11095-012-0739-z. Epub 2012 Apr 7.

2.

Investigation of the Physico-Chemical Properties that Enable Co-Formulation of Basal Insulin Degludec with Fast-Acting Insulin Aspart.

Havelund S, Ribel U, Hubálek F, Hoeg-Jensen T, Wahlund PO, Jonassen I.

Pharm Res. 2015 Jul;32(7):2250-8. doi: 10.1007/s11095-014-1614-x. Epub 2015 Jan 8.

3.

Ligand-controlled assembly of hexamers, dihexamers, and linear multihexamer structures by the engineered acylated insulin degludec.

Steensgaard DB, Schluckebier G, Strauss HM, Norrman M, Thomsen JK, Friderichsen AV, Havelund S, Jonassen I.

Biochemistry. 2013 Jan 15;52(2):295-309. doi: 10.1021/bi3008609. Epub 2013 Jan 3.

PMID:
23256685
4.

Biochemical and physiological properties of a novel series of long-acting insulin analogs obtained by acylation with cholic acid derivatives.

Jonassen I, Havelund S, Ribel U, Plum A, Loftager M, Hoeg-Jensen T, Volund A, Markussen J.

Pharm Res. 2006 Jan;23(1):49-55. Epub 2006 Dec 21.

PMID:
16362452
5.

The mechanism of protraction of insulin detemir, a long-acting, acylated analog of human insulin.

Havelund S, Plum A, Ribel U, Jonassen I, Vølund A, Markussen J, Kurtzhals P.

Pharm Res. 2004 Aug;21(8):1498-504.

PMID:
15359587
6.
7.

Self-association of long-acting insulin analogues studied by size exclusion chromatography coupled to multi-angle light scattering.

Jensen MH, Wahlund PO, Jacobsen JK, Vestergaard B, van de Weert M, Havelund S.

J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Oct 15;879(28):2945-51. doi: 10.1016/j.jchromb.2011.05.059. Epub 2011 Jul 26.

PMID:
21937288
8.

Crystal structure of a prolonged-acting insulin with albumin-binding properties.

Whittingham JL, Havelund S, Jonassen I.

Biochemistry. 1997 Mar 11;36(10):2826-31.

PMID:
9062110
9.

Small angle X-ray scattering-based elucidation of the self-association mechanism of human insulin analogue lys(B29)(N(ε)ω-carboxyheptadecanoyl) des(B30).

Jensen MH, Wahlund PO, Toft KN, Jacobsen JK, Steensgaard DB, van de Weert M, Havelund S, Vestergaard B.

Biochemistry. 2013 Jan 15;52(2):282-94. doi: 10.1021/bi3008615. Epub 2013 Jan 3.

PMID:
23256662
10.

Acylation of human insulin with palmitic acid extends the time action of human insulin in diabetic dogs.

Myers SR, Yakubu-Madus FE, Johnson WT, Baker JE, Cusick TS, Williams VK, Tinsley FC, Kriauciunas A, Manetta J, Chen VJ.

Diabetes. 1997 Apr;46(4):637-42.

PMID:
9075804
11.

Degludec, a new ultra-long-acting basal insulin for the treatment of diabetes mellitus type 1 and 2: advances in clinical research.

Muñoz Torres M.

Endocrinol Nutr. 2014 Mar;61(3):153-9. doi: 10.1016/j.endonu.2013.03.012. Epub 2013 Jul 25. Review.

PMID:
23890782
12.

Altering the association properties of insulin by amino acid replacement.

Brems DN, Alter LA, Beckage MJ, Chance RE, DiMarchi RD, Green LK, Long HB, Pekar AH, Shields JE, Frank BH.

Protein Eng. 1992 Sep;5(6):527-33.

PMID:
1438163
13.

Soluble, fatty acid acylated insulins bind to albumin and show protracted action in pigs.

Markussen J, Havelund S, Kurtzhals P, Andersen AS, Halstrøm J, Hasselager E, Larsen UD, Ribel U, Schäffer L, Vad K, Jonassen I.

Diabetologia. 1996 Mar;39(3):281-8.

PMID:
8721773
14.

Review of Clinical Profile of IDegAsp.

Unnikrishnan AG, Singh AK, Modi KD, Saboo B, Garcha SC, Rao PV.

J Assoc Physicians India. 2015 May;63(5 Suppl):15-20. Review.

PMID:
26548030
15.

Effect of fatty acids and selected drugs on the albumin binding of a long-acting, acylated insulin analogue.

Kurtzhals P, Havelund S, Jonassen I, Markussen J.

J Pharm Sci. 1997 Dec;86(12):1365-8.

PMID:
9423147
17.

Rapid-Acting and Human Insulins: Hexamer Dissociation Kinetics upon Dilution of the Pharmaceutical Formulation.

Gast K, Schüler A, Wolff M, Thalhammer A, Berchtold H, Nagel N, Lenherr G, Hauck G, Seckler R.

Pharm Res. 2017 Jul 31. doi: 10.1007/s11095-017-2233-0. [Epub ahead of print]

PMID:
28762200
18.

The development of new basal insulins: is there any clinical advantage with their use in type 2 diabetes?

Maiorino MI, Petrizzo M, Capuano A, Giugliano D, Esposito K.

Expert Opin Biol Ther. 2014 Jun;14(6):799-808. doi: 10.1517/14712598.2014.895812. Epub 2014 Mar 27. Review.

PMID:
24673155
19.

Degludec: the new ultra-long insulin analogue.

Tambascia MA, Eliaschewitz FG.

Diabetol Metab Syndr. 2015 Jun 26;7:57. doi: 10.1186/s13098-015-0037-0. eCollection 2015.

20.

New insulins and insulin therapy.

Danne T, Bolinder J.

Int J Clin Pract Suppl. 2011 Feb;(170):26-30. doi: 10.1111/j.1742-1241.2010.02576.x. Review.

PMID:
21323810

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