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Items: 1 to 20 of 137

1.

Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals.

Gonzalez-Gutierrez G, Lukk T, Agarwal V, Papke D, Nair SK, Grosman C.

Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6331-6. doi: 10.1073/pnas.1119268109. Epub 2012 Apr 2.

2.

Multisite binding of a general anesthetic to the prokaryotic pentameric Erwinia chrysanthemi ligand-gated ion channel (ELIC).

Spurny R, Billen B, Howard RJ, Brams M, Debaveye S, Price KL, Weston DA, Strelkov SV, Tytgat J, Bertrand S, Bertrand D, Lummis SC, Ulens C.

J Biol Chem. 2013 Mar 22;288(12):8355-64. doi: 10.1074/jbc.M112.424507. Epub 2013 Jan 30.

3.

Macroscopic kinetics of pentameric ligand gated ion channels: comparisons between two prokaryotic channels and one eukaryotic channel.

Laha KT, Ghosh B, Czajkowski C.

PLoS One. 2013 Nov 19;8(11):e80322. doi: 10.1371/journal.pone.0080322. eCollection 2013.

4.

The prokaryote ligand-gated ion channel ELIC captured in a pore blocker-bound conformation by the Alzheimer's disease drug memantine.

Ulens C, Spurny R, Thompson AJ, Alqazzaz M, Debaveye S, Han L, Price K, Villalgordo JM, Tresadern G, Lynch JW, Lummis SC.

Structure. 2014 Oct 7;22(10):1399-407. doi: 10.1016/j.str.2014.07.013. Epub 2014 Sep 4.

5.

Site-directed spin labeling reveals pentameric ligand-gated ion channel gating motions.

Dellisanti CD, Ghosh B, Hanson SM, Raspanti JM, Grant VA, Diarra GM, Schuh AM, Satyshur K, Klug CS, Czajkowski C.

PLoS Biol. 2013 Nov;11(11):e1001714. doi: 10.1371/journal.pbio.1001714. Epub 2013 Nov 19.

6.

Structural Basis of Alcohol Inhibition of the Pentameric Ligand-Gated Ion Channel ELIC.

Chen Q, Wells MM, Tillman TS, Kinde MN, Cohen A, Xu Y, Tang P.

Structure. 2017 Jan 3;25(1):180-187. doi: 10.1016/j.str.2016.11.007. Epub 2016 Dec 1.

PMID:
27916519
7.

Phenylalanine in the pore of the Erwinia ligand-gated ion channel modulates picrotoxinin potency but not receptor function.

Thompson AJ, Alqazzaz M, Price KL, Weston DA, Lummis SC.

Biochemistry. 2014 Oct 7;53(39):6183-8. doi: 10.1021/bi5008035. Epub 2014 Sep 19.

8.

Functional characterization of two prokaryotic pentameric ligand-gated ion channel chimeras - role of the GLIC transmembrane domain in proton sensing.

Hénault CM, Baenziger JE.

Biochim Biophys Acta. 2017 Feb;1859(2):218-227. doi: 10.1016/j.bbamem.2016.11.006. Epub 2016 Nov 12.

PMID:
27845033
9.

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel.

Hilf RJ, Dutzler R.

Nature. 2009 Jan 1;457(7225):115-8. doi: 10.1038/nature07461. Epub 2008 Nov 5.

PMID:
18987630
10.

Ligand activation of the prokaryotic pentameric ligand-gated ion channel ELIC.

Zimmermann I, Dutzler R.

PLoS Biol. 2011 Jun;9(6):e1001101. doi: 10.1371/journal.pbio.1001101. Epub 2011 Jun 21.

11.

The atypical cation-conduction and gating properties of ELIC underscore the marked functional versatility of the pentameric ligand-gated ion-channel fold.

Gonzalez-Gutierrez G, Grosman C.

J Gen Physiol. 2015 Jul;146(1):15-36. doi: 10.1085/jgp.201411333. Epub 2015 Jun 15.

12.
13.

Mechanism of activation of the prokaryotic channel ELIC by propylamine: a single-channel study.

Marabelli A, Lape R, Sivilotti L.

J Gen Physiol. 2015 Jan;145(1):23-45. doi: 10.1085/jgp.201411234.

14.

Intramembrane aromatic interactions influence the lipid sensitivities of pentameric ligand-gated ion channels.

Carswell CL, Sun J, Baenziger JE.

J Biol Chem. 2015 Jan 23;290(4):2496-507. doi: 10.1074/jbc.M114.624395. Epub 2014 Dec 17.

15.

Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine.

Pan J, Chen Q, Willenbring D, Yoshida K, Tillman T, Kashlan OB, Cohen A, Kong XP, Xu Y, Tang P.

Nat Commun. 2012 Mar 6;3:714. doi: 10.1038/ncomms1703.

16.

Gating of the proton-gated ion channel from Gloeobacter violaceus at pH 4 as revealed by X-ray crystallography.

Gonzalez-Gutierrez G, Cuello LG, Nair SK, Grosman C.

Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18716-21. doi: 10.1073/pnas.1313156110. Epub 2013 Oct 28.

17.

Inhibition of the prokaryotic pentameric ligand-gated ion channel ELIC by divalent cations.

Zimmermann I, Marabelli A, Bertozzi C, Sivilotti LG, Dutzler R.

PLoS Biol. 2012;10(11):e1001429. doi: 10.1371/journal.pbio.1001429. Epub 2012 Nov 20.

18.

Conformational Changes Underlying Desensitization of the Pentameric Ligand-Gated Ion Channel ELIC.

Kinde MN, Chen Q, Lawless MJ, Mowrey DD, Xu J, Saxena S, Xu Y, Tang P.

Structure. 2015 Jun 2;23(6):995-1004. doi: 10.1016/j.str.2015.03.017. Epub 2015 May 7.

19.

A cost-effective protocol for the over-expression and purification of fully-functional and more stable Erwinia chrysanthemi ligand-gated ion channel.

Elberson BW, Whisenant TE, Cortes DM, Cuello LG.

Protein Expr Purif. 2017 May;133:177-186. doi: 10.1016/j.pep.2017.03.006. Epub 2017 Mar 7.

PMID:
28279818
20.

Molecular-dynamics simulations of ELIC-a prokaryotic homologue of the nicotinic acetylcholine receptor.

Cheng X, Ivanov I, Wang H, Sine SM, McCammon JA.

Biophys J. 2009 Jun 3;96(11):4502-13. doi: 10.1016/j.bpj.2009.03.018.

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