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Items: 1 to 20 of 111

1.

Lentiviral vector induced insertional haploinsufficiency of Ebf1 causes murine leukemia.

Heckl D, Schwarzer A, Haemmerle R, Steinemann D, Rudolph C, Skawran B, Knoess S, Krause J, Li Z, Schlegelberger B, Baum C, Modlich U.

Mol Ther. 2012 Jun;20(6):1187-95. doi: 10.1038/mt.2012.59. Epub 2012 Apr 3.

2.

Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia.

Heltemes-Harris LM, Willette MJ, Ramsey LB, Qiu YH, Neeley ES, Zhang N, Thomas DA, Koeuth T, Baechler EC, Kornblau SM, Farrar MA.

J Exp Med. 2011 Jun 6;208(6):1135-49. doi: 10.1084/jem.20101947. Epub 2011 May 23.

3.

Murine leukemia following irradiation conditioning for transplantation of lentivirally-modified hematopoietic stem cells.

Siapati EK, Bigger BW, Kashofer K, Themis M, Thrasher AJ, Bonnet D.

Eur J Haematol. 2007 Apr;78(4):303-13.

PMID:
17378892
4.

Whole transcriptome characterization of aberrant splicing events induced by lentiviral vector integrations.

Cesana D, Sgualdino J, Rudilosso L, Merella S, Naldini L, Montini E.

J Clin Invest. 2012 May;122(5):1667-76. doi: 10.1172/JCI62189. Epub 2012 Apr 23.

5.

Polyclonal fluctuation of lentiviral vector-transduced and expanded murine hematopoietic stem cells.

Maetzig T, Brugman MH, Bartels S, Heinz N, Kustikova OS, Modlich U, Li Z, Galla M, Schiedlmeier B, Schambach A, Baum C.

Blood. 2011 Mar 17;117(11):3053-64. doi: 10.1182/blood-2010-08-303222. Epub 2011 Jan 19.

6.

Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells.

Schambach A, Bohne J, Chandra S, Will E, Margison GP, Williams DA, Baum C.

Mol Ther. 2006 Feb;13(2):391-400. Epub 2005 Oct 12.

7.

Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines.

Weber-Nordt RM, Egen C, Wehinger J, Ludwig W, Gouilleux-Gruart V, Mertelsmann R, Finke J.

Blood. 1996 Aug 1;88(3):809-16.

8.

Alpharetroviral self-inactivating vectors: long-term transgene expression in murine hematopoietic cells and low genotoxicity.

Suerth JD, Maetzig T, Brugman MH, Heinz N, Appelt JU, Kaufmann KB, Schmidt M, Grez M, Modlich U, Baum C, Schambach A.

Mol Ther. 2012 May;20(5):1022-32. doi: 10.1038/mt.2011.309. Epub 2012 Feb 14.

9.
10.

Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis.

Woods NB, Muessig A, Schmidt M, Flygare J, Olsson K, Salmon P, Trono D, von Kalle C, Karlsson S.

Blood. 2003 Feb 15;101(4):1284-9. Epub 2002 Oct 17.

11.

Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors.

Modlich U, Navarro S, Zychlinski D, Maetzig T, Knoess S, Brugman MH, Schambach A, Charrier S, Galy A, Thrasher AJ, Bueren J, Baum C.

Mol Ther. 2009 Nov;17(11):1919-28. doi: 10.1038/mt.2009.179. Epub 2009 Aug 11.

12.

Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia.

Heltemes-Harris LM, Larson JD, Starr TK, Hubbard GK, Sarver AL, Largaespada DA, Farrar MA.

Oncogene. 2016 Jun 30;35(26):3454-64. doi: 10.1038/onc.2015.405. Epub 2015 Oct 26.

13.

Transduction of human hematopoietic stem cells by lentiviral vectors pseudotyped with the RD114-TR chimeric envelope glycoprotein.

Di Nunzio F, Piovani B, Cosset FL, Mavilio F, Stornaiuolo A.

Hum Gene Ther. 2007 Sep;18(9):811-20.

PMID:
17824830
14.

Reduced genotoxicity of avian sarcoma leukosis virus vectors in rhesus long-term repopulating cells compared to standard murine retrovirus vectors.

Hu J, Renaud G, Gomes TJ, Ferris A, Hendrie PC, Donahue RE, Hughes SH, Wolfsberg TG, Russell DW, Dunbar CE.

Mol Ther. 2008 Sep;16(9):1617-23. doi: 10.1038/mt.2008.135. Epub 2008 Jun 24. Erratum in: Mol Ther. 2008 Oct;16(10):1770.. Golmes, Theotonius [corrected to Gomes, Theotonius J].

15.
16.

Comparison of gene-trapping efficiency between retroviral and lentiviral vectors in mouse embryonic stem cells.

Yamaguchi T, Morikawa A, Miyoshi H.

Biochem Biophys Res Commun. 2012 Aug 24;425(2):297-303. doi: 10.1016/j.bbrc.2012.07.085. Epub 2012 Jul 25.

PMID:
22842569
17.

Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration.

Montini E, Cesana D, Schmidt M, Sanvito F, Ponzoni M, Bartholomae C, Sergi Sergi L, Benedicenti F, Ambrosi A, Di Serio C, Doglioni C, von Kalle C, Naldini L.

Nat Biotechnol. 2006 Jun;24(6):687-96. Epub 2006 May 28.

PMID:
16732270
18.

High incidence of proviral integrations in the Hoxa locus in a new model of E2a-PBX1-induced B-cell leukemia.

Bijl J, Sauvageau M, Thompson A, Sauvageau G.

Genes Dev. 2005 Jan 15;19(2):224-33.

19.
20.

Deletion of the LTR enhancer/promoter has no impact on the integration profile of MLV vectors in human hematopoietic progenitors.

Moiani A, Miccio A, Rizzi E, Severgnini M, Pellin D, Suerth JD, Baum C, De Bellis G, Mavilio F.

PLoS One. 2013;8(1):e55721. doi: 10.1371/journal.pone.0055721. Epub 2013 Jan 31.

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