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Bivalent and co-operative binding of complement factor H to heparan sulfate and heparin.

Khan S, Nan R, Gor J, Mulloy B, Perkins SJ.

Biochem J. 2012 Jun 15;444(3):417-28. doi: 10.1042/BJ20120183.


The regulatory SCR-1/5 and cell surface-binding SCR-16/20 fragments of factor H reveal partially folded-back solution structures and different self-associative properties.

Okemefuna AI, Gilbert HE, Griggs KM, Ormsby RJ, Gordon DL, Perkins SJ.

J Mol Biol. 2008 Jan 4;375(1):80-101. Epub 2007 Sep 14.


Binding of complement factor H to endothelial cells is mediated by the carboxy-terminal glycosaminoglycan binding site.

Jokiranta TS, Cheng ZZ, Seeberger H, Jòzsi M, Heinen S, Noris M, Remuzzi G, Ormsby R, Gordon DL, Meri S, Hellwage J, Zipfel PF.

Am J Pathol. 2005 Oct;167(4):1173-81.


Complement C3b/C3d and cell surface polyanions are recognized by overlapping binding sites on the most carboxyl-terminal domain of complement factor H.

Hellwage J, Jokiranta TS, Friese MA, Wolk TU, Kampen E, Zipfel PF, Meri S.

J Immunol. 2002 Dec 15;169(12):6935-44.


Localization of the third heparin-binding site in the human complement regulator factor H1.

Ormsby RJ, Jokiranta TS, Duthy TG, Griggs KM, Sadlon TA, Giannakis E, Gordon DL.

Mol Immunol. 2006 Apr;43(10):1624-32. Epub 2005 Nov 2.


Implications of the progressive self-association of wild-type human factor H for complement regulation and disease.

Nan R, Gor J, Perkins SJ.

J Mol Biol. 2008 Jan 25;375(4):891-900. Epub 2007 Nov 13.


Complement factor H binds at two independent sites to C-reactive protein in acute phase concentrations.

Okemefuna AI, Nan R, Miller A, Gor J, Perkins SJ.

J Biol Chem. 2010 Jan 8;285(2):1053-65. doi: 10.1074/jbc.M109.044529. Epub 2009 Oct 22.


Interaction of lipoprotein lipase with heparin fragments and with heparan sulfate: stoichiometry, stabilization, and kinetics.

Lookene A, Chevreuil O, Ostergaard P, Olivecrona G.

Biochemistry. 1996 Sep 17;35(37):12155-63.


The human complement regulator factor H binds pneumococcal surface protein PspC via short consensus repeats 13 to 15.

Duthy TG, Ormsby RJ, Giannakis E, Ogunniyi AD, Stroeher UH, Paton JC, Gordon DL.

Infect Immun. 2002 Oct;70(10):5604-11.


Associative and structural properties of the region of complement factor H encompassing the Tyr402His disease-related polymorphism and its interactions with heparin.

Fernando AN, Furtado PB, Clark SJ, Gilbert HE, Day AJ, Sim RB, Perkins SJ.

J Mol Biol. 2007 Apr 27;368(2):564-81. Epub 2007 Feb 22.


Identification of the second heparin-binding domain in human complement factor H.

Blackmore TK, Hellwage J, Sadlon TA, Higgs N, Zipfel PF, Ward HM, Gordon DL.

J Immunol. 1998 Apr 1;160(7):3342-8.


Identification of a domain in human factor H and factor H-like protein-1 required for the interaction with streptococcal M proteins.

Kotarsky H, Hellwage J, Johnsson E, Skerka C, Svensson HG, Lindahl G, Sjöbring U, Zipfel PF.

J Immunol. 1998 Apr 1;160(7):3349-54.


The partly folded back solution structure arrangement of the 30 SCR domains in human complement receptor type 1 (CR1) permits access to its C3b and C4b ligands.

Furtado PB, Huang CY, Ihyembe D, Hammond RA, Marsh HC, Perkins SJ.

J Mol Biol. 2008 Jan 4;375(1):102-18. Epub 2007 Oct 3.


A common site within factor H SCR 7 responsible for binding heparin, C-reactive protein and streptococcal M protein.

Giannakis E, Jokiranta TS, Male DA, Ranganathan S, Ormsby RJ, Fischetti VA, Mold C, Gordon DL.

Eur J Immunol. 2003 Apr;33(4):962-9.


Identification of a heparin binding domain in the seventh short consensus repeat of complement factor H.

Blackmore TK, Sadlon TA, Ward HM, Lublin DM, Gordon DL.

J Immunol. 1996 Dec 15;157(12):5422-7.


Characterization of heparin and heparan sulfate domains binding to the long splice variant of platelet-derived growth factor A chain.

Feyzi E, Lustig F, Fager G, Spillmann D, Lindahl U, Salmivirta M.

J Biol Chem. 1997 Feb 28;272(9):5518-24.


Binding of heparin/heparan sulfate to fibroblast growth factor receptor 4.

Loo BM, Kreuger J, Jalkanen M, Lindahl U, Salmivirta M.

J Biol Chem. 2001 May 18;276(20):16868-76. Epub 2001 Feb 21.

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