Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 400

1.

Amyloid precursor protein (APP) mediated regulation of ganglioside homeostasis linking Alzheimer's disease pathology with ganglioside metabolism.

Grimm MO, Zinser EG, Grösgen S, Hundsdörfer B, Rothhaar TL, Burg VK, Kaestner L, Bayer TA, Lipp P, Müller U, Grimm HS, Hartmann T.

PLoS One. 2012;7(3):e34095. doi: 10.1371/journal.pone.0034095. Epub 2012 Mar 28.

2.
3.

Elimination of GD3 synthase improves memory and reduces amyloid-beta plaque load in transgenic mice.

Bernardo A, Harrison FE, McCord M, Zhao J, Bruchey A, Davies SS, Jackson Roberts L 2nd, Mathews PM, Matsuoka Y, Ariga T, Yu RK, Thompson R, McDonald MP.

Neurobiol Aging. 2009 Nov;30(11):1777-91. doi: 10.1016/j.neurobiolaging.2007.12.022. Epub 2008 Feb 6.

PMID:
18258340
4.

Upregulation of PGC-1α expression by Alzheimer's disease-associated pathway: presenilin 1/amyloid precursor protein (APP)/intracellular domain of APP.

Robinson A, Grösgen S, Mett J, Zimmer VC, Haupenthal VJ, Hundsdörfer B, Stahlmann CP, Slobodskoy Y, Müller UC, Hartmann T, Stein R, Grimm MO.

Aging Cell. 2014 Apr;13(2):263-72. doi: 10.1111/acel.12183. Epub 2013 Dec 17.

5.

ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology.

Sakae N, Liu CC, Shinohara M, Frisch-Daiello J, Ma L, Yamazaki Y, Tachibana M, Younkin L, Kurti A, Carrasquillo MM, Zou F, Sevlever D, Bisceglio G, Gan M, Fol R, Knight P, Wang M, Han X, Fryer JD, Fitzgerald ML, Ohyagi Y, Younkin SG, Bu G, Kanekiyo T.

J Neurosci. 2016 Mar 30;36(13):3848-59. doi: 10.1523/JNEUROSCI.3757-15.2016.

6.

Intracellular amyloid precursor protein sorting and amyloid-β secretion are regulated by Src-mediated phosphorylation of Mint2.

Chaufty J, Sullivan SE, Ho A.

J Neurosci. 2012 Jul 11;32(28):9613-25. doi: 10.1523/JNEUROSCI.0602-12.2012.

7.

PS dependent APP cleavage regulates glucosylceramide synthase and is affected in Alzheimer's disease.

Grimm MO, Hundsdörfer B, Grösgen S, Mett J, Zimmer VC, Stahlmann CP, Haupenthal VJ, Rothhaar TL, Lehmann J, Pätzold A, Zinser EG, Tanila H, Shen J, Müller U, Grimm HS, Hartmann T.

Cell Physiol Biochem. 2014;34(1):92-110. doi: 10.1159/000362987. Epub 2014 Jun 16.

8.

Ganglioside-Dependent Neural Stem Cell Proliferation in Alzheimer's Disease Model Mice.

Koon NA, Itokazu Y, Yu RK.

ASN Neuro. 2015 Dec 23;7(6). pii: 1759091415618916. doi: 10.1177/1759091415618916. Print 2015 Nov-Dec.

9.

Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions.

Li X, Uemura K, Hashimoto T, Nasser-Ghodsi N, Arimon M, Lill CM, Palazzolo I, Krainc D, Hyman BT, Berezovska O.

Neurobiol Dis. 2013 Feb;50:127-34. doi: 10.1016/j.nbd.2012.10.002. Epub 2012 Oct 12.

10.

Evidence that enzyme processivity mediates differential Aβ production by PS1 and PS2.

Pintchovski SA, Schenk DB, Basi GS.

Curr Alzheimer Res. 2013 Jan;10(1):4-10.

11.

APP Regulates Microglial Phenotype in a Mouse Model of Alzheimer's Disease.

Manocha GD, Floden AM, Rausch K, Kulas JA, McGregor BA, Rojanathammanee L, Puig KR, Puig KL, Karki S, Nichols MR, Darland DC, Porter JE, Combs CK.

J Neurosci. 2016 Aug 10;36(32):8471-86. doi: 10.1523/JNEUROSCI.4654-15.2016.

12.

Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis.

Xiao Q, Yan P, Ma X, Liu H, Perez R, Zhu A, Gonzales E, Tripoli DL, Czerniewski L, Ballabio A, Cirrito JR, Diwan A, Lee JM.

J Neurosci. 2015 Sep 2;35(35):12137-51. doi: 10.1523/JNEUROSCI.0705-15.2015.

13.

Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons.

Yang GZ, Yang M, Lim Y, Lu JJ, Wang TH, Qi JG, Zhong JH, Zhou XF.

J Neurochem. 2012 Sep;122(5):1010-22. doi: 10.1111/j.1471-4159.2012.07845.x.

14.

Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates beta-amyloid deposition through upregulating alpha-secretase in vivo and in vitro.

Mei Z, Zhang F, Tao L, Zheng W, Cao Y, Wang Z, Tang S, Le K, Chen S, Pi R, Liu P.

Neurosci Lett. 2009 Mar 13;452(2):90-5. doi: 10.1016/j.neulet.2009.01.013. Epub 2009 Jan 13.

PMID:
19154776
15.

Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations.

Quintero-Monzon O, Martin MM, Fernandez MA, Cappello CA, Krzysiak AJ, Osenkowski P, Wolfe MS.

Biochemistry. 2011 Oct 25;50(42):9023-35. doi: 10.1021/bi2007146. Epub 2011 Sep 30.

16.

Gamma secretase-activating protein is a substrate for caspase-3: implications for Alzheimer's disease.

Chu J, Li JG, Joshi YB, Giannopoulos PF, Hoffman NE, Madesh M, Praticò D.

Biol Psychiatry. 2015 Apr 15;77(8):720-8. doi: 10.1016/j.biopsych.2014.06.003. Epub 2014 Jun 16.

17.

Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.

Evin G, Zhu A, Holsinger RM, Masters CL, Li QX.

J Neurosci Res. 2003 Nov 1;74(3):386-92.

PMID:
14598315
18.
19.

Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin Overexpression.

Saito T, Matsuba Y, Yamazaki N, Hashimoto S, Saido TC.

J Neurosci. 2016 Sep 21;36(38):9933-6. doi: 10.1523/JNEUROSCI.1907-16.2016.

20.

Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease.

Paris D, Ganey NJ, Laporte V, Patel NS, Beaulieu-Abdelahad D, Bachmeier C, March A, Ait-Ghezala G, Mullan MJ.

J Neuroinflammation. 2010 Mar 8;7:17. doi: 10.1186/1742-2094-7-17.

Supplemental Content

Support Center