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Mitochondrial superoxide mediates doxorubicin-induced keratinocyte apoptosis through oxidative modification of ERK and Bcl-2 ubiquitination.

Luanpitpong S, Chanvorachote P, Nimmannit U, Leonard SS, Stehlik C, Wang L, Rojanasakul Y.

Biochem Pharmacol. 2012 Jun 15;83(12):1643-54. doi: 10.1016/j.bcp.2012.03.010. Epub 2012 Mar 24.


Reactive oxygen species mediate heat stress-induced apoptosis via ERK dephosphorylation and Bcl-2 ubiquitination in human umbilical vein endothelial cells.

Li L, Tan H, Yang H, Li F, He X, Gu Z, Zhao M, Su L.

Oncotarget. 2017 Feb 21;8(8):12902-12916. doi: 10.18632/oncotarget.14186.


Hydroxyl radical mediates cisplatin-induced apoptosis in human hair follicle dermal papilla cells and keratinocytes through Bcl-2-dependent mechanism.

Luanpitpong S, Nimmannit U, Chanvorachote P, Leonard SS, Pongrakhananon V, Wang L, Rojanasakul Y.

Apoptosis. 2011 Aug;16(8):769-82. doi: 10.1007/s10495-011-0609-x.


Reactive oxygen species mediate doxorubicin induced p53-independent apoptosis.

Tsang WP, Chau SP, Kong SK, Fung KP, Kwok TT.

Life Sci. 2003 Sep 5;73(16):2047-58.


Superoxide-mediated proteasomal degradation of Bcl-2 determines cell susceptibility to Cr(VI)-induced apoptosis.

Azad N, Iyer AK, Manosroi A, Wang L, Rojanasakul Y.

Carcinogenesis. 2008 Aug;29(8):1538-45. doi: 10.1093/carcin/bgn137. Epub 2008 Jun 9.


Superoxide anions are involved in doxorubicin-induced ERK activation in hepatocyte cultures.

Navarro R, Busnadiego I, Ruiz-Larrea MB, Ruiz-Sanz JI.

Ann N Y Acad Sci. 2006 Dec;1090:419-28.


Molecular pathways involved in the anti-apoptotic effect of 1,25-dihydroxyvitamin D3 in primary human keratinocytes.

De Haes P, Garmyn M, Carmeliet G, Degreef H, Vantieghem K, Bouillon R, Segaert S.

J Cell Biochem. 2004 Nov 15;93(5):951-67.


Regulation of apoptosis by Bcl-2 cysteine oxidation in human lung epithelial cells.

Luanpitpong S, Chanvorachote P, Stehlik C, Tse W, Callery PS, Wang L, Rojanasakul Y.

Mol Biol Cell. 2013 Mar;24(6):858-69. doi: 10.1091/mbc.E12-10-0747. Epub 2013 Jan 30.


Cadmium induces apoptosis in pancreatic β-cells through a mitochondria-dependent pathway: the role of oxidative stress-mediated c-Jun N-terminal kinase activation.

Chang KC, Hsu CC, Liu SH, Su CC, Yen CC, Lee MJ, Chen KL, Ho TJ, Hung DZ, Wu CC, Lu TH, Su YC, Chen YW, Huang CF.

PLoS One. 2013;8(2):e54374. doi: 10.1371/journal.pone.0054374. Epub 2013 Feb 6.


Inhibition of doxorubicin-induced autophagy in hepatocellular carcinoma Hep3B cells by sorafenib--the role of extracellular signal-regulated kinase counteraction.

Manov I, Pollak Y, Broneshter R, Iancu TC.

FEBS J. 2011 Sep;278(18):3494-507. doi: 10.1111/j.1742-4658.2011.08271.x.


Anticancer effects of Ac‑Phe‑Lys‑PABC‑doxorubicin via mitochondria‑centered apoptosis involving reactive oxidative stress and the ERK1/2 signaling pathway in MGC‑803 cells.

Zhong YJ, Liu SP, Firestone RA, Hong YP, Li Y.

Oncol Rep. 2013 Oct;30(4):1681-6. doi: 10.3892/or.2013.2629. Epub 2013 Jul 19.


Paradoxical effects of metalloporphyrins on doxorubicin-induced apoptosis: scavenging of reactive oxygen species versus induction of heme oxygenase-1.

Konorev EA, Kotamraju S, Zhao H, Kalivendi S, Joseph J, Kalyanaraman B.

Free Radic Biol Med. 2002 Oct 1;33(7):988.


Efficient induction of apoptosis by doxorubicin coupled to cell-penetrating peptides compared to unconjugated doxorubicin in the human breast cancer cell line MDA-MB 231.

Aroui S, Brahim S, De Waard M, Bréard J, Kenani A.

Cancer Lett. 2009 Nov 18;285(1):28-38. doi: 10.1016/j.canlet.2009.04.044. Epub 2009 Jun 11.


Mitochondria-derived reactive oxygen species play an important role in Doxorubicin-induced platelet apoptosis.

Wang Z, Wang J, Xie R, Liu R, Lu Y.

Int J Mol Sci. 2015 May 15;16(5):11087-100. doi: 10.3390/ijms160511087.


Protein kinase C-ERK1/2 signal pathway switches glucose depletion-induced necrosis to apoptosis by regulating superoxide dismutases and suppressing reactive oxygen species production in A549 lung cancer cells.

Kim CH, Han SI, Lee SY, Youk HS, Moon JY, Duong HQ, Park MJ, Joo YM, Park HG, Kim YJ, Yoo MA, Lim SC, Kang HS.

J Cell Physiol. 2007 May;211(2):371-85.


Nitric oxide suppresses apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions.

Wenzel U, Kuntz S, De Sousa UJ, Daniel H.

Int J Cancer. 2003 Sep 20;106(5):666-75.


Doxorubicin activates nuclear factor of activated T-lymphocytes and Fas ligand transcription: role of mitochondrial reactive oxygen species and calcium.

Kalivendi SV, Konorev EA, Cunningham S, Vanamala SK, Kaji EH, Joseph J, Kalyanaraman B.

Biochem J. 2005 Jul 15;389(Pt 2):527-39.


Quinacrine induces apoptosis in human leukemia K562 cells via p38 MAPK-elicited BCL2 down-regulation and suppression of ERK/c-Jun-mediated BCL2L1 expression.

Changchien JJ, Chen YJ, Huang CH, Cheng TL, Lin SR, Chang LS.

Toxicol Appl Pharmacol. 2015 Apr 1;284(1):33-41. doi: 10.1016/j.taap.2015.02.005. Epub 2015 Feb 12.


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