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Items: 1 to 20 of 98

1.

Mechanism-based CYP2D6 inactivation by acridone alkaloids of Indonesian medicinal plant Lunasia amara.

Takahashi N, Subehan, Kadota S, Tezuka Y.

Fitoterapia. 2012 Jun;83(4):774-9. doi: 10.1016/j.fitote.2012.03.011. Epub 2012 Mar 17.

PMID:
22465502
2.

Mechanism-based inhibition of human liver microsomal cytochrome P450 2D6 (CYP2D6) by alkamides of Piper nigrum.

Subehan, Usia T, Kadota S, Tezuka Y.

Planta Med. 2006 May;72(6):527-32.

PMID:
16808005
3.

Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants.

Subehan, Usia T, Iwata H, Kadota S, Tezuka Y.

J Ethnopharmacol. 2006 May 24;105(3):449-55. Epub 2006 Jan 18.

PMID:
16414224
4.

Constituents of Indonesian medicinal plant Averrhoa bilimbi and their cytochrome P450 3A4 and 2D6 inhibitory activities.

Auw L, Subehan, Sukrasno, Kadota S, Tezuka Y.

Nat Prod Commun. 2015 Jan;10(1):57-62.

PMID:
25920220
5.

Effect of Curcuma longa on CYP2D6- and CYP3A4-mediated metabolism of dextromethorphan in human liver microsomes and healthy human subjects.

Al-Jenoobi FI, Al-Thukair AA, Alam MA, Abbas FA, Al-Mohizea AM, Alkharfy KM, Al-Suwayeh SA.

Eur J Drug Metab Pharmacokinet. 2015 Mar;40(1):61-6. doi: 10.1007/s13318-014-0180-2. Epub 2014 Feb 9.

PMID:
24510399
6.

Guanfu base A, an antiarrhythmic alkaloid of Aconitum coreanum, Is a CYP2D6 inhibitor of human, monkey, and dog isoforms.

Sun J, Peng Y, Wu H, Zhang X, Zhong Y, Xiao Y, Zhang F, Qi H, Shang L, Zhu J, Sun Y, Liu K, Liu J, A J, Ho RJ, Wang G.

Drug Metab Dispos. 2015 May;43(5):713-24. doi: 10.1124/dmd.114.060905. Epub 2015 Feb 13.

7.

Selective inhibition of the cytochrome P450 isoform by hyperoside and its potent inhibition of CYP2D6.

Song M, Hong M, Lee MY, Jee JG, Lee YM, Bae JS, Jeong TC, Lee S.

Food Chem Toxicol. 2013 Sep;59:549-53. doi: 10.1016/j.fct.2013.06.055. Epub 2013 Jul 5.

PMID:
23835282
8.

Effect of black seed on dextromethorphan O- and N-demethylation in human liver microsomes and healthy human subjects.

Al-Jenoobi FI, Al-Thukair AA, Abbas FA, Ansari MJ, Alkharfy KM, Al-Mohizea AM, Al-Suwayeh SA, Jamil S.

Drug Metab Lett. 2010 Jan;4(1):51-5.

PMID:
20201775
9.

Bioactive acridone alkaloids from Swinglea glutinosa.

Weniger B, Um BH, Valentin A, Estrada A, Lobstein A, Anton R, Maillé M, Sauvain M.

J Nat Prod. 2001 Sep;64(9):1221-3.

PMID:
11575960
10.

The effect of cimetidine on dextromethorphan O-demethylase activity of human liver microsomes and recombinant CYP2D6.

Madeira M, Levine M, Chang TK, Mirfazaelian A, Bellward GD.

Drug Metab Dispos. 2004 Apr;32(4):460-7.

11.

Quinoline alkaloids from Lunasia amara inhibit Mycobacterium tuberculosis H37Rv in vitro.

Aguinaldo AM, Dalangin-Mallari VM, Macabeo AP, Byrne LT, Abe F, Yamauchi T, Franzblau SG.

Int J Antimicrob Agents. 2007 Jun;29(6):744-6. Epub 2007 Mar 30. No abstract available.

PMID:
17399957
12.

Identification and characterization of potent CYP2D6 inhibitors in lotus leaves.

Ye LH, He XX, Kong LT, Liao YH, Pan RL, Xiao BX, Liu XM, Chang Q.

J Ethnopharmacol. 2014 Apr 11;153(1):190-6. doi: 10.1016/j.jep.2014.02.014. Epub 2014 Feb 21.

PMID:
24561383
13.

Cytochrome P450 2D6 (CYP2D6) inhibitory constituents of Catharanthus roseus.

Usia T, Watabe T, Kadota S, Tezuka Y.

Biol Pharm Bull. 2005 Jun;28(6):1021-4.

14.

Lotus leaf alkaloid fraction can strongly inhibit CYP2D6 isoenzyme activity.

Ye LH, Kong LT, Yan MZ, Cao FR, Wang LS, Liao YH, Pan RL, Chang Q.

J Ethnopharmacol. 2016 Dec 24;194:913-917. doi: 10.1016/j.jep.2016.10.055. Epub 2016 Oct 19.

PMID:
27771456
15.

Modulation of drug-metabolizing enzymes by extracts of a herbal medicine Evodia rutaecarpa in C57BL/6J mice.

Ueng YF, Ko HC, Chen CF, Wang JJ, Chen KT.

Life Sci. 2002 Aug 2;71(11):1267-77.

PMID:
12106592
16.

Metabolism of dextromethorphan in vitro: involvement of cytochromes P450 2D6 and 3A3/4, with a possible role of 2E1.

Schmider J, Greenblatt DJ, Fogelman SM, von Moltke LL, Shader RI.

Biopharm Drug Dispos. 1997 Apr;18(3):227-40.

PMID:
9113345
17.

Investigation of CYP3A4 and CYP2D6 Interactions of Withania somnifera and Centella asiatica in Human Liver Microsomes.

Savai J, Varghese A, Pandita N, Chintamaneni M.

Phytother Res. 2015 May;29(5):785-90. doi: 10.1002/ptr.5308. Epub 2015 Feb 13.

PMID:
25684704
18.

Mechanism-based inactivation of human liver microsomal CYP3A4 by rutaecarpine and limonin from Evodia fruit extract.

Iwata H, Tezuka Y, Kadota S, Hiratsuka A, Watabe T.

Drug Metab Pharmacokinet. 2005 Feb;20(1):34-45.

19.

In vitro modulatory effects on three major human cytochrome P450 enzymes by multiple active constituents and extracts of Centella asiatica.

Pan Y, Abd-Rashid BA, Ismail Z, Ismail R, Mak JW, Pook PC, Er HM, Ong CE.

J Ethnopharmacol. 2010 Jul 20;130(2):275-83. doi: 10.1016/j.jep.2010.05.002. Epub 2010 May 8.

PMID:
20457244
20.

Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes.

Misaka S, Kawabe K, Onoue S, Werba JP, Giroli M, Tamaki S, Kan T, Kimura J, Watanabe H, Yamada S.

Drug Metab Pharmacokinet. 2013;28(3):244-9. Epub 2012 Dec 25.

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