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Analysis of Panax notoginseng metabolites in rat bile by liquid chromatography-quadrupole time-of-flight mass spectrometry with microdialysis sampling.

Wen XD, Yang J, Ma RH, Gao W, Qi LW, Li P, Bauer BA, Du GJ, Zhang Z, Somogyi J, Wang CZ, Yuan CS.

J Chromatogr B Analyt Technol Biomed Life Sci. 2012 May 1;895-896:162-8. doi: 10.1016/j.jchromb.2012.03.009. Epub 2012 Mar 15.


Metabolism of ginsenosides Rk₃ and Rh₄ from steamed notoginseng in zebrafish by ultraperformance liquid chromatography/quadrupole-time-of-flight mass spectrometry.

Chen B, Wei Y, Wang D, Jia X.

Arch Pharm Res. 2015 Aug;38(8):1468-76. doi: 10.1007/s12272-014-0538-7. Epub 2014 Dec 30.


Combinatorial metabolism notably affects human systemic exposure to ginsenosides from orally administered extract of Panax notoginseng roots (Sanqi).

Hu Z, Yang J, Cheng C, Huang Y, Du F, Wang F, Niu W, Xu F, Jiang R, Gao X, Li C.

Drug Metab Dispos. 2013 Jul;41(7):1457-69. doi: 10.1124/dmd.113.051391. Epub 2013 May 6.


Brain distribution pharmacokinetics and integrated pharmacokinetics of Panax Notoginsenoside R1, Ginsenosides Rg1, Rb1, Re and Rd in rats after intranasal administration of Panax Notoginseng Saponins assessed by UPLC/MS/MS.

Guo Q, Li P, Wang Z, Cheng Y, Wu H, Yang B, Du S, Lu Y.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Oct 15;969:264-71. doi: 10.1016/j.jchromb.2014.08.034. Epub 2014 Sep 3.


Development of a systematic approach to rapid classification and identification of notoginsenosides and metabolites in rat feces based on liquid chromatography coupled triple time-of-flight mass spectrometry.

Xing R, Zhou L, Xie L, Hao K, Rao T, Wang Q, Ye W, Fu H, Wang X, Wang G, Liang Y.

Anal Chim Acta. 2015 Mar 31;867:56-66. doi: 10.1016/j.aca.2015.02.039. Epub 2015 Feb 16.


Determination of American ginseng saponins and their metabolites in human plasma, urine and feces samples by liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.

Wan JY, Wang CZ, Liu Z, Zhang QH, Musch MW, Bissonnette M, Chang EB, Li P, Qi LW, Yuan CS.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Mar 15;1015-1016:62-73. doi: 10.1016/j.jchromb.2016.02.008. Epub 2016 Feb 6.


Identification of metabolites of Danggui Buxue Tang in rat urine by liquid chromatography coupled with electrospray ionization time-of-flight mass spectrometry.

Li CY, Qi LW, Li P, Wen XD, Zhu YF, Liu EH, Gong Z, Yang XL, Ren MT, Li YJ, Ge XX.

Rapid Commun Mass Spectrom. 2009 Jul;23(13):1977-88. doi: 10.1002/rcm.4110.


Biotransformation and metabolic profile of American ginseng saponins with human intestinal microflora by liquid chromatography quadrupole time-of-flight mass spectrometry.

Wan JY, Liu P, Wang HY, Qi LW, Wang CZ, Li P, Yuan CS.

J Chromatogr A. 2013 Apr 19;1286:83-92. doi: 10.1016/j.chroma.2013.02.053. Epub 2013 Feb 26.


Development and validation of an UFLC-MS/MS assay for the absolute quantitation of nine notoginsenosides in rat plasma: Application to the pharmacokinetic study of Panax Notoginseng Extract.

Zhou L, Xing R, Xie L, Rao T, Wang Q, Ye W, Fu H, Xiao J, Shao Y, Kang D, Wang G, Liang Y.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jul 15;995-996:46-53. doi: 10.1016/j.jchromb.2015.05.022. Epub 2015 May 19.


Metabolism study of notoginsenoside R1, ginsenoside Rg1 and ginsenoside Rb1 of radix Panax notoginseng in zebrafish.

Wei Y, Li P, Fan H, Peng Y, Liu W, Wang C, Shu L, Jia X.

Molecules. 2011 Aug 5;16(8):6621-33. doi: 10.3390/molecules16086621.


Liquid chromatography/quadrupole time-of-flight mass spectrometry in combination with online hydrogen/deuterium exchange technique for structural elucidation of phase I metabolites of iso-phenylcyclopentylamine in rat bile.

Liu X, Wang S, Ding L, Chen X, Shen W, Dong X, Yun C, Lin H.

Biomed Chromatogr. 2014 Oct;28(10):1335-44. doi: 10.1002/bmc.3170. Epub 2014 Mar 17.


UPLC-Q-TOF/MS-based screening and identification of the main flavonoids and their metabolites in rat bile, urine and feces after oral administration of Scutellaria baicalensis extract.

Du LY, Qian DW, Shang EX, Liu P, Jiang S, Guo JM, Su SL, Duan JA, Xu J, Zhao M.

J Ethnopharmacol. 2015 Jul 1;169:156-62. doi: 10.1016/j.jep.2015.04.039. Epub 2015 Apr 27.


[Effects of root rot on saponin content in Panax notoginseng].

Sun Y, Ke J, Ma N, Chen Z, Wang C, Cui X.

Zhong Yao Cai. 2004 Feb;27(2):79-80. Chinese.


Transformation of ginsenosides from notoginseng by artificial gastric juice can increase cytotoxicity toward cancer cells.

Wang JR, Yau LF, Zhang R, Xia Y, Ma J, Ho HM, Hu P, Hu M, Liu L, Jiang ZH.

J Agric Food Chem. 2014 Mar 26;62(12):2558-73. doi: 10.1021/jf405482s. Epub 2014 Mar 11.


Identification of the potential active components of Abelmoschus manihot in rat blood and kidney tissue by microdialysis combined with ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry.

Xue C, Guo J, Qian D, Duan JA, Shang E, Shu Y, Lu Y.

J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Feb 15;879(5-6):317-25. doi: 10.1016/j.jchromb.2010.12.016. Epub 2010 Dec 28.


In vitro biotransformation of red ginseng extract by human intestinal microflora: metabolites identification and metabolic profile elucidation using LC-Q-TOF/MS.

Wang HY, Hua HY, Liu XY, Liu JH, Yu BY.

J Pharm Biomed Anal. 2014 Sep;98:296-306. doi: 10.1016/j.jpba.2014.06.006. Epub 2014 Jun 11.


Analysis of the chemical constituents and rats metabolites after oral administration of Nauclea officinalis by ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry.

Zhu F, Chen J, Wang H, Jia X, Wang S, Zhang Z, Zhai X, Xu J, Tan W, Ning Q, Gu J.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Dec 15;1007:54-66. doi: 10.1016/j.jchromb.2015.10.032. Epub 2015 Oct 31.


UPLC-Q-TOF/MS-based screening and identification of two major bioactive components and their metabolites in normal and CKD rat plasma, urine and feces after oral administration of Rehmannia glutinosa Libosch extract.

Tao JH, Zhao M, Wang DG, Yang C, Chen GT, Zhao X, Pu XL, Jiang S.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Sep 15;1001:98-106. doi: 10.1016/j.jchromb.2015.07.035. Epub 2015 Jul 30.


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