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Targeting dynorphin/kappa opioid receptor systems to treat alcohol abuse and dependence.

Walker BM, Valdez GR, McLaughlin JP, Bakalkin G.

Alcohol. 2012 Jun;46(4):359-70. doi: 10.1016/j.alcohol.2011.10.006. Epub 2012 Mar 27. Review.


Conceptualizing withdrawal-induced escalation of alcohol self-administration as a learned, plasticity-dependent process.

Walker BM.

Alcohol. 2012 Jun;46(4):339-48. doi: 10.1016/j.alcohol.2012.01.001. Epub 2012 Mar 28. Review.


The one-two punch of alcoholism: role of central amygdala dynorphins/kappa-opioid receptors.

Kissler JL, Sirohi S, Reis DJ, Jansen HT, Quock RM, Smith DG, Walker BM.

Biol Psychiatry. 2014 May 15;75(10):774-82. doi: 10.1016/j.biopsych.2013.03.014. Epub 2013 Apr 21.


κ opioid regulation of anxiety-like behavior during acute ethanol withdrawal.

Valdez GR, Harshberger E.

Pharmacol Biochem Behav. 2012 Jul;102(1):44-7. doi: 10.1016/j.pbb.2012.03.019. Epub 2012 Apr 2.


Dissociating Motivational From Physiological Withdrawal in Alcohol Dependence: Role of Central Amygdala κ-Opioid Receptors.

Kissler JL, Walker BM.

Neuropsychopharmacology. 2016 Jan;41(2):560-7. doi: 10.1038/npp.2015.183. Epub 2015 Jun 24.


Role of the Dynorphin/Kappa Opioid Receptor System in the Motivational Effects of Ethanol.

Anderson RI, Becker HC.

Alcohol Clin Exp Res. 2017 Aug;41(8):1402-1418. doi: 10.1111/acer.13406. Epub 2017 Jun 5. Review.


Affective cue-induced escalation of alcohol self-administration and increased 22-kHz ultrasonic vocalizations during alcohol withdrawal: role of kappa-opioid receptors.

Berger AL, Williams AM, McGinnis MM, Walker BM.

Neuropsychopharmacology. 2013 Mar;38(4):647-54. doi: 10.1038/npp.2012.229. Epub 2012 Nov 6.


Kappa opioid receptor activation decreases inhibitory transmission and antagonizes alcohol effects in rat central amygdala.

Gilpin NW, Roberto M, Koob GF, Schweitzer P.

Neuropharmacology. 2014 Feb;77:294-302. doi: 10.1016/j.neuropharm.2013.10.005. Epub 2013 Oct 21.


Species differences in the effects of the κ-opioid receptor antagonist zyklophin.

Sirohi S, Aldrich JV, Walker BM.

Alcohol. 2016 Mar;51:43-9. doi: 10.1016/j.alcohol.2015.11.012. Epub 2016 Jan 29.


Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats.

Walker BM, Zorrilla EP, Koob GF.

Addict Biol. 2011 Jan;16(1):116-9. doi: 10.1111/j.1369-1600.2010.00226.x.


Neurobiological mechanisms contributing to alcohol-stress-anxiety interactions.

Silberman Y, Bajo M, Chappell AM, Christian DT, Cruz M, Diaz MR, Kash T, Lack AK, Messing RO, Siggins GR, Winder D, Roberto M, McCool BA, Weiner JL.

Alcohol. 2009 Nov;43(7):509-19. doi: 10.1016/j.alcohol.2009.01.002. Review.


The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety.

Schank JR, Goldstein AL, Rowe KE, King CE, Marusich JA, Wiley JL, Carroll FI, Thorsell A, Heilig M.

Addict Biol. 2012 May;17(3):634-47. doi: 10.1111/j.1369-1600.2012.00455.x.


The kappa-opioid receptor antagonist, nor-binaltorphimine (nor-BNI), decreases morphine withdrawal and the consequent conditioned place aversion in rats.

Kelsey JE, Verhaak AM, Schierberl KC.

Behav Brain Res. 2015 Apr 15;283:16-21. doi: 10.1016/j.bbr.2015.01.008. Epub 2015 Jan 13.


Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence.

Walker BM, Koob GF.

Neuropsychopharmacology. 2008 Feb;33(3):643-52. Epub 2007 May 2.


Dynorphin/Kappa Opioid Receptor Signaling in Preclinical Models of Alcohol, Drug, and Food Addiction.

Karkhanis A, Holleran KM, Jones SR.

Int Rev Neurobiol. 2017;136:53-88. doi: 10.1016/bs.irn.2017.08.001. Epub 2017 Sep 12. Review.


Protracted withdrawal from ethanol and enhanced responsiveness stress: regulation via the dynorphin/kappa opioid receptor system.

Gillett K, Harshberger E, Valdez GR.

Alcohol. 2013 Aug;47(5):359-65. doi: 10.1016/j.alcohol.2013.05.001. Epub 2013 May 31.


Kappa-Opioid Antagonists for Psychiatric Disorders: From Bench to Clinical Trials.

Carlezon WA Jr, Krystal AD.

Depress Anxiety. 2016 Oct;33(10):895-906. doi: 10.1002/da.22500. Review.


Stress produces aversion and potentiates cocaine reward by releasing endogenous dynorphins in the ventral striatum to locally stimulate serotonin reuptake.

Schindler AG, Messinger DI, Smith JS, Shankar H, Gustin RM, Schattauer SS, Lemos JC, Chavkin NW, Hagan CE, Neumaier JF, Chavkin C.

J Neurosci. 2012 Dec 5;32(49):17582-96. doi: 10.1523/JNEUROSCI.3220-12.2012.


Dynorphin, stress, and depression.

Knoll AT, Carlezon WA Jr.

Brain Res. 2010 Feb 16;1314:56-73. doi: 10.1016/j.brainres.2009.09.074. Epub 2009 Sep 24. Review.


Treatment of alcohol dependence with drug antagonists of the stress response.

Higley AE, Koob GF, Mason BJ.

Alcohol Res. 2012;34(4):516-21.

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