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Targeted gene inactivation reveals a functional role of calpain-1 in platelet spreading.

Kuchay SM, Wieschhaus AJ, Marinkovic M, Herman IM, Chishti AH.

J Thromb Haemost. 2012 Jun;10(6):1120-32. doi: 10.1111/j.1538-7836.2012.04715.x.


Loss of oligophrenin1 leads to uncontrolled Rho activation and increased thrombus formation in mice.

Fotinos A, Klier M, Gowert NS, Münzer P, Klatt C, Beck S, Borst O, Billuart P, Schaller M, Lang F, Gawaz M, Elvers M.

J Thromb Haemost. 2015 Apr;13(4):619-30. doi: 10.1111/jth.12834. Epub 2015 Jan 29.


Isoform-specific roles of the GTPase activating protein Nadrin in cytoskeletal reorganization of platelets.

Beck S, Fotinos A, Lang F, Gawaz M, Elvers M.

Cell Signal. 2013 Jan;25(1):236-46. doi: 10.1016/j.cellsig.2012.09.005. Epub 2012 Sep 10.


Differential role of Rho GTPases in intestinal epithelial barrier regulation in vitro.

Schlegel N, Meir M, Spindler V, Germer CT, Waschke J.

J Cell Physiol. 2011 May;226(5):1196-203. doi: 10.1002/jcp.22446.


Double knockouts reveal that protein tyrosine phosphatase 1B is a physiological target of calpain-1 in platelets.

Kuchay SM, Kim N, Grunz EA, Fay WP, Chishti AH.

Mol Cell Biol. 2007 Sep;27(17):6038-52. Epub 2007 Jun 18.


Nadrin GAP activity is isoform- and target-specific regulated by tyrosine phosphorylation.

Beck S, Fotinos A, Gawaz M, Elvers M.

Cell Signal. 2014 Sep;26(9):1975-84. doi: 10.1016/j.cellsig.2014.03.024. Epub 2014 Apr 2.


Discoidin domain receptor 1 activation suppresses alpha2beta1 integrin-dependent cell spreading through inhibition of Cdc42 activity.

Yeh YC, Wang CZ, Tang MJ.

J Cell Physiol. 2009 Jan;218(1):146-56. doi: 10.1002/jcp.21578.


Cdc42 downregulates MMP-1 expression by inhibiting the ERK1/2 pathway.

Deroanne CF, Hamelryckx D, Ho TT, Lambert CA, Catroux P, Lapière CM, Nusgens BV.

J Cell Sci. 2005 Mar 15;118(Pt 6):1173-83. Epub 2005 Feb 22.


Critical off-target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse platelets.

Dütting S, Heidenreich J, Cherpokova D, Amin E, Zhang SC, Ahmadian MR, Brakebusch C, Nieswandt B.

J Thromb Haemost. 2015 May;13(5):827-38. doi: 10.1111/jth.12861. Epub 2015 Feb 23.


The proline-rich tyrosine kinase Pyk2 regulates platelet integrin αIIbβ3 outside-in signaling.

Cipolla L, Consonni A, Guidetti G, Canobbio I, Okigaki M, Falasca M, Ciraolo E, Hirsch E, Balduini C, Torti M.

J Thromb Haemost. 2013 Feb;11(2):345-56. doi: 10.1111/jth.12099.


ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner.

I ST, Nie Z, Stewart A, Najdovska M, Hall NE, He H, Randazzo PA, Lock P.

J Cell Sci. 2004 Dec 1;117(Pt 25):6071-84. Epub 2004 Nov 16.


A role of STAT3 in Rho GTPase-regulated cell migration and proliferation.

Debidda M, Wang L, Zang H, Poli V, Zheng Y.

J Biol Chem. 2005 Apr 29;280(17):17275-85. Epub 2005 Feb 10.


Activation of type I phosphatidylinositol 4-phosphate 5-kinase isoforms by the Rho GTPases, RhoA, Rac1, and Cdc42.

Weernink PA, Meletiadis K, Hommeltenberg S, Hinz M, Ishihara H, Schmidt M, Jakobs KH.

J Biol Chem. 2004 Feb 27;279(9):7840-9. Epub 2003 Dec 17.


Palladin is involved in platelet activation and arterial thrombosis.

Chen X, Fan X, Tan J, Shi P, Wang X, Wang J, Kuang Y, Fei J, Liu J, Dang S, Wang Z.

Thromb Res. 2017 Jan;149:1-8. doi: 10.1016/j.thromres.2016.11.010. Epub 2016 Nov 10.


Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis.

Pleines I, Hagedorn I, Gupta S, May F, Chakarova L, van Hengel J, Offermanns S, Krohne G, Kleinschnitz C, Brakebusch C, Nieswandt B.

Blood. 2012 Jan 26;119(4):1054-63. doi: 10.1182/blood-2011-08-372193. Epub 2011 Nov 1.


Cooperative anti-invasive effect of Cdc42/Rac1 activation and ROCK inhibition in SW620 colorectal cancer cells with elevated blebbing activity.

de Toledo M, Anguille C, Roger L, Roux P, Gadea G.

PLoS One. 2012;7(11):e48344. doi: 10.1371/journal.pone.0048344. Epub 2012 Nov 7.


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