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Items: 1 to 20 of 390

1.

Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis.

Couthouis J, Hart MP, Erion R, King OD, Diaz Z, Nakaya T, Ibrahim F, Kim HJ, Mojsilovic-Petrovic J, Panossian S, Kim CE, Frackelton EC, Solski JA, Williams KL, Clay-Falcone D, Elman L, McCluskey L, Greene R, Hakonarson H, Kalb RG, Lee VM, Trojanowski JQ, Nicholson GA, Blair IP, Bonini NM, Van Deerlin VM, Mourelatos Z, Shorter J, Gitler AD.

Hum Mol Genet. 2012 Jul 1;21(13):2899-911. doi: 10.1093/hmg/dds116. Epub 2012 Mar 27.

2.

A yeast functional screen predicts new candidate ALS disease genes.

Couthouis J, Hart MP, Shorter J, DeJesus-Hernandez M, Erion R, Oristano R, Liu AX, Ramos D, Jethava N, Hosangadi D, Epstein J, Chiang A, Diaz Z, Nakaya T, Ibrahim F, Kim HJ, Solski JA, Williams KL, Mojsilovic-Petrovic J, Ingre C, Boylan K, Graff-Radford NR, Dickson DW, Clay-Falcone D, Elman L, McCluskey L, Greene R, Kalb RG, Lee VM, Trojanowski JQ, Ludolph A, Robberecht W, Andersen PM, Nicholson GA, Blair IP, King OD, Bonini NM, Van Deerlin V, Rademakers R, Mourelatos Z, Gitler AD.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):20881-90. doi: 10.1073/pnas.1109434108. Epub 2011 Nov 7.

3.

Aggregation of FET Proteins as a Pathological Change in Amyotrophic Lateral Sclerosis.

Furukawa Y, Tokuda E.

Adv Exp Med Biol. 2017;925:1-12. doi: 10.1007/5584_2016_32. Review.

PMID:
27311318
4.

RNA-binding proteins with prion-like domains in health and disease.

Harrison AF, Shorter J.

Biochem J. 2017 Apr 7;474(8):1417-1438. doi: 10.1042/BCJ20160499. Review.

5.

RNA-binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutations.

Daigle JG, Lanson NA Jr, Smith RB, Casci I, Maltare A, Monaghan J, Nichols CD, Kryndushkin D, Shewmaker F, Pandey UB.

Hum Mol Genet. 2013 Mar 15;22(6):1193-205. doi: 10.1093/hmg/dds526. Epub 2012 Dec 20.

6.

A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43.

Lanson NA Jr, Maltare A, King H, Smith R, Kim JH, Taylor JP, Lloyd TE, Pandey UB.

Hum Mol Genet. 2011 Jul 1;20(13):2510-23. doi: 10.1093/hmg/ddr150. Epub 2011 Apr 12.

7.

The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease.

King OD, Gitler AD, Shorter J.

Brain Res. 2012 Jun 26;1462:61-80. doi: 10.1016/j.brainres.2012.01.016. Epub 2012 Jan 21. Review.

8.

Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in a Drosophila model of Fus-mediated ALS.

Xia R, Liu Y, Yang L, Gal J, Zhu H, Jia J.

Mol Neurodegener. 2012 Mar 24;7:10. doi: 10.1186/1750-1326-7-10.

9.

The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span.

Wang JW, Brent JR, Tomlinson A, Shneider NA, McCabe BD.

J Clin Invest. 2011 Oct;121(10):4118-26. doi: 10.1172/JCI57883. Epub 2011 Sep 1.

10.

The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis.

Nishimoto Y, Nakagawa S, Hirose T, Okano HJ, Takao M, Shibata S, Suyama S, Kuwako K, Imai T, Murayama S, Suzuki N, Okano H.

Mol Brain. 2013 Jul 8;6:31. doi: 10.1186/1756-6606-6-31.

11.

Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis.

Kwiatkowski TJ Jr, Bosco DA, Leclerc AL, Tamrazian E, Vanderburg CR, Russ C, Davis A, Gilchrist J, Kasarskis EJ, Munsat T, Valdmanis P, Rouleau GA, Hosler BA, Cortelli P, de Jong PJ, Yoshinaga Y, Haines JL, Pericak-Vance MA, Yan J, Ticozzi N, Siddique T, McKenna-Yasek D, Sapp PC, Horvitz HR, Landers JE, Brown RH Jr.

Science. 2009 Feb 27;323(5918):1205-8. doi: 10.1126/science.1166066.

12.

Aberrant localization of FUS and TDP43 is associated with misfolding of SOD1 in amyotrophic lateral sclerosis.

Pokrishevsky E, Grad LI, Yousefi M, Wang J, Mackenzie IR, Cashman NR.

PLoS One. 2012;7(4):e35050. doi: 10.1371/journal.pone.0035050. Epub 2012 Apr 6.

13.

Co-aggregation of RNA binding proteins in ALS spinal motor neurons: evidence of a common pathogenic mechanism.

Keller BA, Volkening K, Droppelmann CA, Ang LC, Rademakers R, Strong MJ.

Acta Neuropathol. 2012 Nov;124(5):733-47. doi: 10.1007/s00401-012-1035-z. Epub 2012 Sep 1.

PMID:
22941224
14.

Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs.

Lagier-Tourenne C, Polymenidou M, Hutt KR, Vu AQ, Baughn M, Huelga SC, Clutario KM, Ling SC, Liang TY, Mazur C, Wancewicz E, Kim AS, Watt A, Freier S, Hicks GG, Donohue JP, Shiue L, Bennett CF, Ravits J, Cleveland DW, Yeo GW.

Nat Neurosci. 2012 Nov;15(11):1488-97. doi: 10.1038/nn.3230. Epub 2012 Sep 30.

15.

FET proteins in frontotemporal dementia and amyotrophic lateral sclerosis.

Mackenzie IR, Neumann M.

Brain Res. 2012 Jun 26;1462:40-3. doi: 10.1016/j.brainres.2011.12.010. Epub 2011 Dec 13. Review.

PMID:
22261247
16.

Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations.

Neumann M, Valori CF, Ansorge O, Kretzschmar HA, Munoz DG, Kusaka H, Yokota O, Ishihara K, Ang LC, Bilbao JM, Mackenzie IR.

Acta Neuropathol. 2012 Nov;124(5):705-16. doi: 10.1007/s00401-012-1020-6. Epub 2012 Jul 28.

PMID:
22842875
17.

Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways.

Blokhuis AM, Koppers M, Groen EJ, van den Heuvel DM, Dini Modigliani S, Anink JJ, Fumoto K, van Diggelen F, Snelting A, Sodaar P, Verheijen BM, Demmers JA, Veldink JH, Aronica E, Bozzoni I, den Hertog J, van den Berg LH, Pasterkamp RJ.

Acta Neuropathol. 2016 Aug;132(2):175-96. doi: 10.1007/s00401-016-1575-8. Epub 2016 May 10.

18.

TDP-43 and FUS/TLS: sending a complex message about messenger RNA in amyotrophic lateral sclerosis?

Strong MJ, Volkening K.

FEBS J. 2011 Oct;278(19):3569-77. doi: 10.1111/j.1742-4658.2011.08277.x. Epub 2011 Sep 6. Review.

19.

Deficient RNA-editing enzyme ADAR2 in an amyotrophic lateral sclerosis patient with a FUS(P525L) mutation.

Aizawa H, Hideyama T, Yamashita T, Kimura T, Suzuki N, Aoki M, Kwak S.

J Clin Neurosci. 2016 Oct;32:128-9. doi: 10.1016/j.jocn.2015.12.039. Epub 2016 Jun 21.

PMID:
27343041
20.

RNA targets of wild-type and mutant FET family proteins.

Hoell JI, Larsson E, Runge S, Nusbaum JD, Duggimpudi S, Farazi TA, Hafner M, Borkhardt A, Sander C, Tuschl T.

Nat Struct Mol Biol. 2011 Nov 13;18(12):1428-31. doi: 10.1038/nsmb.2163.

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