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Kinetic analysis of Enterococcus faecium L,D-transpeptidase inactivation by carbapenems.

Dubée V, Arthur M, Fief H, Triboulet S, Mainardi JL, Gutmann L, Sollogoub M, Rice LB, Ethève-Quelquejeu M, Hugonnet JE.

Antimicrob Agents Chemother. 2012 Jun;56(6):3409-12. doi: 10.1128/AAC.06398-11. Epub 2012 Mar 26.


Kinetic features of L,D-transpeptidase inactivation critical for β-lactam antibacterial activity.

Triboulet S, Dubée V, Lecoq L, Bougault C, Mainardi JL, Rice LB, Ethève-Quelquejeu M, Gutmann L, Marie A, Dubost L, Hugonnet JE, Simorre JP, Arthur M.

PLoS One. 2013 Jul 4;8(7):e67831. doi: 10.1371/journal.pone.0067831. Print 2013.


Structure of Enterococcus faeciuml,d-transpeptidase acylated by ertapenem provides insight into the inactivation mechanism.

Lecoq L, Dubée V, Triboulet S, Bougault C, Hugonnet JE, Arthur M, Simorre JP.

ACS Chem Biol. 2013;8(6):1140-6. doi: 10.1021/cb4001603. Epub 2013 Apr 12.


Acyl acceptor recognition by Enterococcus faecium L,D-transpeptidase Ldtfm.

Triboulet S, Bougault CM, Laguri C, Hugonnet JE, Arthur M, Simorre JP.

Mol Microbiol. 2015 Oct;98(1):90-100. doi: 10.1111/mmi.13104. Epub 2015 Jul 17.


Unexpected inhibition of peptidoglycan LD-transpeptidase from Enterococcus faecium by the beta-lactam imipenem.

Mainardi JL, Hugonnet JE, Rusconi F, Fourgeaud M, Dubost L, Moumi AN, Delfosse V, Mayer C, Gutmann L, Rice LB, Arthur M.

J Biol Chem. 2007 Oct 19;282(42):30414-22. Epub 2007 Jul 23.


Inactivation of Mycobacterium tuberculosis l,d-transpeptidase LdtMt₁ by carbapenems and cephalosporins.

Dubée V, Triboulet S, Mainardi JL, Ethève-Quelquejeu M, Gutmann L, Marie A, Dubost L, Hugonnet JE, Arthur M.

Antimicrob Agents Chemother. 2012 Aug;56(8):4189-95. doi: 10.1128/AAC.00665-12. Epub 2012 May 21.


Chemical shift perturbations induced by the acylation of Enterococcus faecium L,D-transpeptidase catalytic cysteine with ertapenem.

Lecoq L, Bougault C, Triboulet S, Dubée V, Hugonnet JE, Arthur M, Simorre JP.

Biomol NMR Assign. 2014 Oct;8(2):339-43. doi: 10.1007/s12104-013-9513-3. Epub 2013 Aug 2.


Structure-activity relationships of different beta-lactam antibiotics against a soluble form of Enterococcus faecium PBP5, a type II bacterial transpeptidase.

Hujer AM, Kania M, Gerken T, Anderson VE, Buynak JD, Ge X, Caspers P, Page MG, Rice LB, Bonomo RA.

Antimicrob Agents Chemother. 2005 Feb;49(2):612-8.


Specificity of L,D-transpeptidases from gram-positive bacteria producing different peptidoglycan chemotypes.

Magnet S, Arbeloa A, Mainardi JL, Hugonnet JE, Fourgeaud M, Dubost L, Marie A, Delfosse V, Mayer C, Rice LB, Arthur M.

J Biol Chem. 2007 May 4;282(18):13151-9. Epub 2007 Feb 20.


Activation of the L,D-transpeptidation peptidoglycan cross-linking pathway by a metallo-D,D-carboxypeptidase in Enterococcus faecium.

Sacco E, Hugonnet JE, Josseaume N, Cremniter J, Dubost L, Marie A, Patin D, Blanot D, Rice LB, Mainardi JL, Arthur M.

Mol Microbiol. 2010 Feb;75(4):874-85. doi: 10.1111/j.1365-2958.2009.07014.x. Epub 2009 Dec 16.


Routes of Synthesis of Carbapenems for Optimizing Both the Inactivation of L,D-Transpeptidase LdtMt1 of Mycobacterium tuberculosis and the Stability toward Hydrolysis by β-Lactamase BlaC.

Iannazzo L, Soroka D, Triboulet S, Fonvielle M, Compain F, Dubée V, Mainardi JL, Hugonnet JE, Braud E, Arthur M, Etheve-Quelquejeu M.

J Med Chem. 2016 Apr 14;59(7):3427-38. doi: 10.1021/acs.jmedchem.6b00096. Epub 2016 Mar 18.


In vitro cross-linking of Mycobacterium tuberculosis peptidoglycan by L,D-transpeptidases and inactivation of these enzymes by carbapenems.

Cordillot M, Dubée V, Triboulet S, Dubost L, Marie A, Hugonnet JE, Arthur M, Mainardi JL.

Antimicrob Agents Chemother. 2013 Dec;57(12):5940-5. doi: 10.1128/AAC.01663-13. Epub 2013 Sep 16.


Serine/threonine protein phosphatase-mediated control of the peptidoglycan cross-linking L,D-transpeptidase pathway in Enterococcus faecium.

Sacco E, Cortes M, Josseaume N, Rice LB, Mainardi JL, Arthur M.

MBio. 2014 Jul 8;5(4):e01446-14. doi: 10.1128/mBio.01446-14.


Balance between two transpeptidation mechanisms determines the expression of beta-lactam resistance in Enterococcus faecium.

Mainardi JL, Morel V, Fourgeaud M, Cremniter J, Blanot D, Legrand R, Frehel C, Arthur M, Van Heijenoort J, Gutmann L.

J Biol Chem. 2002 Sep 27;277(39):35801-7. Epub 2002 Jun 19.


Novel mechanism of resistance to glycopeptide antibiotics in Enterococcus faecium.

Cremniter J, Mainardi JL, Josseaume N, Quincampoix JC, Dubost L, Hugonnet JE, Marie A, Gutmann L, Rice LB, Arthur M.

J Biol Chem. 2006 Oct 27;281(43):32254-62. Epub 2006 Aug 29.


A novel peptidoglycan cross-linking enzyme for a beta-lactam-resistant transpeptidation pathway.

Mainardi JL, Fourgeaud M, Hugonnet JE, Dubost L, Brouard JP, Ouazzani J, Rice LB, Gutmann L, Arthur M.

J Biol Chem. 2005 Nov 18;280(46):38146-52. Epub 2005 Sep 6.


Novel mechanism of beta-lactam resistance due to bypass of DD-transpeptidation in Enterococcus faecium.

Mainardi JL, Legrand R, Arthur M, Schoot B, van Heijenoort J, Gutmann L.

J Biol Chem. 2000 Jun 2;275(22):16490-6.


Inactivation kinetics of a new target of beta-lactam antibiotics.

Triboulet S, Arthur M, Mainardi JL, Veckerlé C, Dubée V, Nguekam-Moumi A, Gutmann L, Rice LB, Hugonnet JE.

J Biol Chem. 2011 Jul 1;286(26):22777-84. doi: 10.1074/jbc.M111.239988. Epub 2011 May 4.


Increasing resistance to beta-lactam antibiotics among clinical isolates of Enterococcus faecium: a 22-year review at one institution.

Grayson ML, Eliopoulos GM, Wennersten CB, Ruoff KL, De Girolami PC, Ferraro MJ, Moellering RC Jr.

Antimicrob Agents Chemother. 1991 Nov;35(11):2180-4.

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