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Neurotoxin-induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of AKT/mTOR signaling.

Selvaraj S, Sun Y, Watt JA, Wang S, Lei S, Birnbaumer L, Singh BB.

J Clin Invest. 2012 Apr;122(4):1354-67. doi: 10.1172/JCI61332.


Parkinson's disease: don't mess with calcium.

Mattson MP.

J Clin Invest. 2012 Apr;122(4):1195-8. doi: 10.1172/JCI62835.


The Ca(2+) sensor stromal interaction molecule 1 (STIM1) is necessary and sufficient for the store-operated Ca(2+) entry function of transient receptor potential canonical (TRPC) 1 and 4 channels in endothelial cells.

Sundivakkam PC, Freichel M, Singh V, Yuan JP, Vogel SM, Flockerzi V, Malik AB, Tiruppathi C.

Mol Pharmacol. 2012 Apr;81(4):510-26. doi: 10.1124/mol.111.074658.


Contribution and regulation of TRPC channels in store-operated Ca2+ entry.

Cheng KT, Ong HL, Liu X, Ambudkar IS.

Curr Top Membr. 2013;71:149-79. doi: 10.1016/B978-0-12-407870-3.00007-X. Review.


TRPC1 inhibits apoptotic cell degeneration induced by dopaminergic neurotoxin MPTP/MPP(+).

Selvaraj S, Watt JA, Singh BB.

Cell Calcium. 2009 Sep;46(3):209-18. doi: 10.1016/j.ceca.2009.07.008.


Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons.

Dragicevic E, Poetschke C, Duda J, Schlaudraff F, Lammel S, Schiemann J, Fauler M, Hetzel A, Watanabe M, Lujan R, Malenka RC, Striessnig J, Liss B.

Brain. 2014 Aug;137(Pt 8):2287-302. doi: 10.1093/brain/awu131.


Resveratrol activates autophagic cell death in prostate cancer cells via downregulation of STIM1 and the mTOR pathway.

Selvaraj S, Sun Y, Sukumaran P, Singh BB.

Mol Carcinog. 2016 May;55(5):818-31. doi: 10.1002/mc.22324.


Activation of TRPC1 by STIM1 in ER-PM microdomains involves release of the channel from its scaffold caveolin-1.

Pani B, Ong HL, Brazer SC, Liu X, Rauser K, Singh BB, Ambudkar IS.

Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20087-92. doi: 10.1073/pnas.0905002106.


Store-Operated Calcium Entry in Müller Glia Is Controlled by Synergistic Activation of TRPC and Orai Channels.

Molnár T, Yarishkin O, Iuso A, Barabas P, Jones B, Marc RE, Phuong TT, Križaj D.

J Neurosci. 2016 Mar 16;36(11):3184-98. doi: 10.1523/JNEUROSCI.4069-15.2016.


Dysregulation of Ca2+ signaling in astrocytes from mice lacking amyloid precursor protein.

Linde CI, Baryshnikov SG, Mazzocco-Spezzia A, Golovina VA.

Am J Physiol Cell Physiol. 2011 Jun;300(6):C1502-12. doi: 10.1152/ajpcell.00379.2010.


Activation of transcription factor MEF2D by bis(3)-cognitin protects dopaminergic neurons and ameliorates Parkinsonian motor defects.

Yao L, Li W, She H, Dou J, Jia L, He Y, Yang Q, Zhu J, Cápiro NL, Walker DI, Pennell KD, Pang Y, Liu Y, Han Y, Mao Z.

J Biol Chem. 2012 Oct 5;287(41):34246-55. doi: 10.1074/jbc.M112.367540.


Contribution of TRPC1 and Orai1 to Ca(2+) entry activated by store depletion.

Cheng KT, Ong HL, Liu X, Ambudkar IS.

Adv Exp Med Biol. 2011;704:435-49. doi: 10.1007/978-94-007-0265-3_24. Review.


Overexpression of transient receptor potential canonical type 1 (TRPC1) alters both store operated calcium entry and depolarization-evoked calcium signals in C2C12 cells.

Oláh T, Fodor J, Ruzsnavszky O, Vincze J, Berbey C, Allard B, Csernoch L.

Cell Calcium. 2011 Jun;49(6):415-25. doi: 10.1016/j.ceca.2011.03.012.


Functional requirement for Orai1 in store-operated TRPC1-STIM1 channels.

Cheng KT, Liu X, Ong HL, Ambudkar IS.

J Biol Chem. 2008 May 9;283(19):12935-40. doi: 10.1074/jbc.C800008200.


mTORC1 enhancement of STIM1-mediated store-operated Ca2+ entry constrains tuberous sclerosis complex-related tumor development.

Peng H, Liu J, Sun Q, Chen R, Wang Y, Duan J, Li C, Li B, Jing Y, Chen X, Mao Q, Xu KF, Walker CL, Li J, Wang J, Zhang H.

Oncogene. 2013 Sep 26;32(39):4702-11. doi: 10.1038/onc.2012.481.


TRPC1 is involved in Ca²⁺ influx and cytotoxicity following Pb²⁺ exposure in human embryonic kidney cells.

Zhang H, Li W, Xue Y, Zou F.

Toxicol Lett. 2014 Aug 17;229(1):52-8. doi: 10.1016/j.toxlet.2014.05.017.


The polybasic lysine-rich domain of plasma membrane-resident STIM1 is essential for the modulation of store-operated divalent cation entry by extracellular calcium.

Jardin I, Dionisio N, Frischauf I, Berna-Erro A, Woodard GE, López JJ, Salido GM, Rosado JA.

Cell Signal. 2013 May;25(5):1328-37. doi: 10.1016/j.cellsig.2013.01.025.


FLZ protects dopaminergic neuron through activating protein kinase B/mammalian target of rapamycin pathway and inhibiting RTP801 expression in Parkinson's disease models.

Bao XQ, Kong XC, Qian C, Zhang D.

Neuroscience. 2012 Jan 27;202:396-404. doi: 10.1016/j.neuroscience.2011.11.036.


Downregulation of miR-124 in MPTP-treated mouse model of Parkinson's disease and MPP iodide-treated MN9D cells modulates the expression of the calpain/cdk5 pathway proteins.

Kanagaraj N, Beiping H, Dheen ST, Tay SS.

Neuroscience. 2014 Jul 11;272:167-79. doi: 10.1016/j.neuroscience.2014.04.039.

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