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Items: 1 to 20 of 96

1.

An apolipoprotein E4 fragment affects matrix metalloproteinase 9, tissue inhibitor of metalloproteinase 1 and cytokine levels in brain cell lines.

Dafnis I, Tzinia AK, Tsilibary EC, Zannis VI, Chroni A.

Neuroscience. 2012 May 17;210:21-32. doi: 10.1016/j.neuroscience.2012.03.013. Epub 2012 Mar 14.

2.

An apolipoprotein E4 fragment can promote intracellular accumulation of amyloid peptide beta 42.

Dafnis I, Stratikos E, Tzinia A, Tsilibary EC, Zannis VI, Chroni A.

J Neurochem. 2010 Nov;115(4):873-84. doi: 10.1111/j.1471-4159.2010.06756.x.

3.

Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.

Brecht WJ, Harris FM, Chang S, Tesseur I, Yu GQ, Xu Q, Dee Fish J, Wyss-Coray T, Buttini M, Mucke L, Mahley RW, Huang Y.

J Neurosci. 2004 Mar 10;24(10):2527-34.

4.

Regulation of IL-1β-induced cyclooxygenase-2 expression by interactions of Aβ peptide, apolipoprotein E and nitric oxide in human neuroglioma.

Samy AS, Igwe OJ.

J Mol Neurosci. 2012 Jul;47(3):533-45. doi: 10.1007/s12031-011-9670-8. Epub 2011 Nov 19.

PMID:
22101739
5.
6.

Molecular basis for increased risk for late-onset Alzheimer disease due to the naturally occurring L28P mutation in apolipoprotein E4.

Argyri L, Dafnis I, Theodossiou TA, Gantz D, Stratikos E, Chroni A.

J Biol Chem. 2014 May 2;289(18):12931-45. doi: 10.1074/jbc.M113.538124. Epub 2014 Mar 18.

7.

The ability of apolipoprotein E fragments to promote intraneuronal accumulation of amyloid beta peptide 42 is both isoform and size-specific.

Dafnis I, Argyri L, Sagnou M, Tzinia A, Tsilibary EC, Stratikos E, Chroni A.

Sci Rep. 2016 Aug 1;6:30654. doi: 10.1038/srep30654.

8.

Identification of an amino-terminal fragment of apolipoprotein E4 that localizes to neurofibrillary tangles of the Alzheimer's disease brain.

Rohn TT, Catlin LW, Coonse KG, Habig JW.

Brain Res. 2012 Sep 26;1475:106-15. doi: 10.1016/j.brainres.2012.08.003. Epub 2012 Aug 8.

PMID:
22902767
9.

Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease.

Chen HK, Ji ZS, Dodson SE, Miranda RD, Rosenblum CI, Reynolds IJ, Freedman SB, Weisgraber KH, Huang Y, Mahley RW.

J Biol Chem. 2011 Feb 18;286(7):5215-21. doi: 10.1074/jbc.M110.151084. Epub 2010 Nov 30.

10.

Human apolipoprotein E4 modulates the expression of Pin1, Sirtuin 1, and Presenilin 1 in brain regions of targeted replacement apoE mice.

Lattanzio F, Carboni L, Carretta D, Rimondini R, Candeletti S, Romualdi P.

Neuroscience. 2014 Jan 3;256:360-9. doi: 10.1016/j.neuroscience.2013.10.017. Epub 2013 Oct 23.

PMID:
24161275
11.

Apolipoprotein-E forms dimers in human frontal cortex and hippocampus.

Elliott DA, Halliday GM, Garner B.

BMC Neurosci. 2010 Feb 20;11:23. doi: 10.1186/1471-2202-11-23.

12.
13.

Matrix metalloproteinase 9 (MMP9) expression in preeclamptic decidua and MMP9 induction by tumor necrosis factor alpha and interleukin 1 beta in human first trimester decidual cells.

Lockwood CJ, Oner C, Uz YH, Kayisli UA, Huang SJ, Buchwalder LF, Murk W, Funai EF, Schatz F.

Biol Reprod. 2008 Jun;78(6):1064-72. doi: 10.1095/biolreprod.107.063743. Epub 2008 Feb 14.

14.

Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models.

Huang Y.

Biochem Soc Trans. 2011 Aug;39(4):924-32. doi: 10.1042/BST0390924.

PMID:
21787325
15.
16.

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.

Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, Berk BC, Zlokovic BV.

Nature. 2012 May 16;485(7399):512-6. doi: 10.1038/nature11087.

17.

Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc.

Harris FM, Brecht WJ, Xu Q, Mahley RW, Huang Y.

J Biol Chem. 2004 Oct 22;279(43):44795-801. Epub 2004 Aug 20.

18.

Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis.

Zhu L, Zhong M, Elder GA, Sano M, Holtzman DM, Gandy S, Cardozo C, Haroutunian V, Robakis NK, Cai D.

Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11965-70. doi: 10.1073/pnas.1510011112. Epub 2015 Sep 8.

19.

apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain.

Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, Holtzman DM, Zlokovic BV.

J Clin Invest. 2008 Dec;118(12):4002-13. doi: 10.1172/JCI36663. Epub 2008 Nov 13.

20.

Isoform-specific proteolysis of apolipoprotein-E in the brain.

Elliott DA, Tsoi K, Holinkova S, Chan SL, Kim WS, Halliday GM, Rye KA, Garner B.

Neurobiol Aging. 2011 Feb;32(2):257-71. doi: 10.1016/j.neurobiolaging.2009.02.006. Epub 2009 Mar 10.

PMID:
19278755

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