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Items: 1 to 20 of 104

1.

Polyketide proofreading by an acyltransferase-like enzyme.

Jensen K, Niederkrüger H, Zimmermann K, Vagstad AL, Moldenhauer J, Brendel N, Frank S, Pöplau P, Kohlhaas C, Townsend CA, Oldiges M, Hertweck C, Piel J.

Chem Biol. 2012 Mar 23;19(3):329-39. doi: 10.1016/j.chembiol.2012.01.005.

PMID:
22444588
2.

Comparative analysis of the substrate specificity of trans- versus cis-acyltransferases of assembly line polyketide synthases.

Dunn BJ, Watts KR, Robbins T, Cane DE, Khosla C.

Biochemistry. 2014 Jun 17;53(23):3796-806. doi: 10.1021/bi5004316. Epub 2014 Jun 9.

PMID:
24871074
3.

Acyl hydrolases from trans-AT polyketide synthases target acetyl units on acyl carrier proteins.

Jenner M, Afonso JP, Kohlhaas C, Karbaum P, Frank S, Piel J, Oldham NJ.

Chem Commun (Camb). 2016 Apr 18;52(30):5262-5. doi: 10.1039/c6cc01453d. Epub 2016 Mar 22.

PMID:
27003309
4.

Biochemical characterization of a malonyl-specific acyltransferase domain of FK506 biosynthetic polyketide synthase.

Wang YY, Bai LF, Ran XX, Jiang XH, Wu H, Zhang W, Jin MY, Li YQ, Jiang H.

Protein Pept Lett. 2015;22(1):2-7.

PMID:
25267255
5.

The AT₂ domain of KirCI loads malonyl extender units to the ACPs of the kirromycin PKS.

Musiol EM, Greule A, Härtner T, Kulik A, Wohlleben W, Weber T.

Chembiochem. 2013 Jul 22;14(11):1343-52. doi: 10.1002/cbic.201300211. Epub 2013 Jul 4.

PMID:
23828654
6.

Ketosynthases in the initiation and elongation modules of aromatic polyketide synthases have orthogonal acyl carrier protein specificity.

Tang Y, Lee TS, Kobayashi S, Khosla C.

Biochemistry. 2003 Jun 3;42(21):6588-95.

PMID:
12767243
7.

Supramolecular templating in kirromycin biosynthesis: the acyltransferase KirCII loads ethylmalonyl-CoA extender onto a specific ACP of the trans-AT PKS.

Musiol EM, Härtner T, Kulik A, Moldenhauer J, Piel J, Wohlleben W, Weber T.

Chem Biol. 2011 Apr 22;18(4):438-44. doi: 10.1016/j.chembiol.2011.02.007.

PMID:
21513880
8.

Catalytic self-acylation of type II polyketide synthase acyl carrier proteins.

Hitchman TS, Crosby J, Byrom KJ, Cox RJ, Simpson TJ.

Chem Biol. 1998 Jan;5(1):35-47.

PMID:
9479478
9.

Polyketide synthase acyl carrier protein (ACP) as a substrate and a catalyst for malonyl ACP biosynthesis.

Zhou P, Florova G, Reynolds KA.

Chem Biol. 1999 Aug;6(8):577-84.

PMID:
10421763
10.

Quantitative analysis of loading and extender acyltransferases of modular polyketide synthases.

Liou GF, Lau J, Cane DE, Khosla C.

Biochemistry. 2003 Jan 14;42(1):200-7.

PMID:
12515555
11.
12.

MCAT is not required for in vitro polyketide synthesis in a minimal actinorhodin polyketide synthase from Streptomyces coelicolor.

Matharu AL, Cox RJ, Crosby J, Byrom KJ, Simpson TJ.

Chem Biol. 1998 Dec;5(12):699-711.

PMID:
9862793
13.
14.

Rapid preparation of (methyl)malonyl coenzyme A and enzymatic formation of unusual polyketides by type III polyketide synthase from Aquilaria sinensis.

Gao BW, Wang XH, Liu X, Shi SP, Tu PF.

Bioorg Med Chem Lett. 2015 Mar 15;25(6):1279-83. doi: 10.1016/j.bmcl.2015.01.045. Epub 2015 Jan 29.

PMID:
25677661
15.

Utilization of enzymatically phosphopantetheinylated acyl carrier proteins and acetyl-acyl carrier proteins by the actinorhodin polyketide synthase.

Carreras CW, Gehring AM, Walsh CT, Khosla C.

Biochemistry. 1997 Sep 30;36(39):11757-61.

PMID:
9305965
16.

Malonyl-coenzyme A:acyl carrier protein acyltransferase of Streptomyces glaucescens: a possible link between fatty acid and polyketide biosynthesis.

Summers RG, Ali A, Shen B, Wessel WA, Hutchinson CR.

Biochemistry. 1995 Jul 25;34(29):9389-402.

PMID:
7626609
17.
18.
19.

Type I polyketide synthases that require discrete acyltransferases.

Cheng YQ, Coughlin JM, Lim SK, Shen B.

Methods Enzymol. 2009;459:165-86. doi: 10.1016/S0076-6879(09)04608-4.

PMID:
19362640
20.

Acyl-chain elongation drives ketosynthase substrate selectivity in trans-acyltransferase polyketide synthases.

Jenner M, Afonso JP, Bailey HR, Frank S, Kampa A, Piel J, Oldham NJ.

Angew Chem Int Ed Engl. 2015 Feb 2;54(6):1817-21. doi: 10.1002/anie.201410219. Epub 2014 Dec 21.

PMID:
25529827

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