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Items: 1 to 20 of 148

1.

Nos2 inactivation promotes the development of medulloblastoma in Ptch1(+/-) mice by deregulation of Gap43-dependent granule cell precursor migration.

Haag D, Zipper P, Westrich V, Karra D, Pfleger K, Toedt G, Blond F, Delhomme N, Hahn M, Reifenberger J, Reifenberger G, Lichter P.

PLoS Genet. 2012;8(3):e1002572. doi: 10.1371/journal.pgen.1002572.

2.

Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma.

Vaillant C, Valdivieso P, Nuciforo S, Kool M, Schwarzentruber-Schauerte A, Méreau H, Cabuy E, Lobrinus JA, Pfister S, Zuniga A, Frank S, Zeller R.

PLoS One. 2015 Apr 22;10(4):e0124870. doi: 10.1371/journal.pone.0124870.

3.

Thickened area of external granular layer and Ki-67 positive focus are early events of medulloblastoma in Ptch1⁺/⁻ mice.

Matsuo S, Takahashi M, Inoue K, Tamura K, Irie K, Kodama Y, Nishikawa A, Yoshida M.

Exp Toxicol Pathol. 2013 Sep;65(6):863-73. doi: 10.1016/j.etp.2012.12.005.

PMID:
23369240
4.
5.

Tis21 knock-out enhances the frequency of medulloblastoma in Patched1 heterozygous mice by inhibiting the Cxcl3-dependent migration of cerebellar neurons.

Farioli-Vecchioli S, Cinà I, Ceccarelli M, Micheli L, Leonardi L, Ciotti MT, De Bardi M, Di Rocco C, Pallini R, Cavallaro S, Tirone F.

J Neurosci. 2012 Oct 31;32(44):15547-64. doi: 10.1523/JNEUROSCI.0412-12.2012.

6.

The Shh receptor Boc promotes progression of early medulloblastoma to advanced tumors.

Mille F, Tamayo-Orrego L, Lévesque M, Remke M, Korshunov A, Cardin J, Bouchard N, Izzi L, Kool M, Northcott PA, Taylor MD, Pfister SM, Charron F.

Dev Cell. 2014 Oct 13;31(1):34-47. doi: 10.1016/j.devcel.2014.08.010.

7.

Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures.

Cohen JR, Resnick DZ, Niewiadomski P, Dong H, Liau LM, Waschek JA.

BMC Cancer. 2010 Dec 9;10:676. doi: 10.1186/1471-2407-10-676.

8.

Patched1 deletion increases N-Myc protein stability as a mechanism of medulloblastoma initiation and progression.

Thomas WD, Chen J, Gao YR, Cheung B, Koach J, Sekyere E, Norris MD, Haber M, Ellis T, Wainwright B, Marshall GM.

Oncogene. 2009 Apr 2;28(13):1605-15. doi: 10.1038/onc.2009.3.

PMID:
19234491
9.

Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma.

Oliver TG, Read TA, Kessler JD, Mehmeti A, Wells JF, Huynh TT, Lin SM, Wechsler-Reya RJ.

Development. 2005 May;132(10):2425-39.

10.

Inhibitory potential of postnatal treatment with cyclopamine, a hedgehog signaling inhibitor, on medulloblastoma development in Ptch1 heterozygous mice.

Matsuo S, Takahashi M, Inoue K, Tamura K, Irie K, Kodama Y, Nishikawa A, Yoshida M.

Toxicol Pathol. 2014 Dec;42(8):1174-87. doi: 10.1177/0192623314530194.

PMID:
24862798
11.

Developmental and oncogenic effects of insulin-like growth factor-I in Ptc1+/- mouse cerebellum.

Tanori M, Santone M, Mancuso M, Pasquali E, Leonardi S, Di Majo V, Rebessi S, Saran A, Pazzaglia S.

Mol Cancer. 2010 Mar 9;9:53. doi: 10.1186/1476-4598-9-53.

12.

Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors.

Oliver TG, Grasfeder LL, Carroll AL, Kaiser C, Gillingham CL, Lin SM, Wickramasinghe R, Scott MP, Wechsler-Reya RJ.

Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7331-6.

13.

Inhibition of medulloblastoma tumorigenesis by the antiproliferative and pro-differentiative gene PC3.

Farioli-Vecchioli S, Tanori M, Micheli L, Mancuso M, Leonardi L, Saran A, Ciotti MT, Ferretti E, Gulino A, Pazzaglia S, Tirone F.

FASEB J. 2007 Jul;21(9):2215-25.

14.

MicroRNA Biogenesis and Hedgehog-Patched Signaling Cooperate to Regulate an Important Developmental Transition in Granule Cell Development.

Constantin L, Constantin M, Wainwright BJ.

Genetics. 2016 Mar;202(3):1105-18. doi: 10.1534/genetics.115.184176.

PMID:
26773048
15.

Expression of Sonic hedgehog during cell proliferation in the human cerebellum.

Haldipur P, Bharti U, Govindan S, Sarkar C, Iyengar S, Gressens P, Mani S.

Stem Cells Dev. 2012 May 1;21(7):1059-68. doi: 10.1089/scd.2011.0206.

PMID:
21732818
16.

Insulin receptor substrate 1 is an effector of sonic hedgehog mitogenic signaling in cerebellar neural precursors.

Parathath SR, Mainwaring LA, Fernandez-L A, Campbell DO, Kenney AM.

Development. 2008 Oct;135(19):3291-300. doi: 10.1242/dev.022871.

17.

Loss of cyclin D1 impairs cerebellar development and suppresses medulloblastoma formation.

Pogoriler J, Millen K, Utset M, Du W.

Development. 2006 Oct;133(19):3929-37.

18.

Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas.

Leung C, Lingbeek M, Shakhova O, Liu J, Tanger E, Saremaslani P, Van Lohuizen M, Marino S.

Nature. 2004 Mar 18;428(6980):337-41.

PMID:
15029199
19.
20.

Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma.

Briggs KJ, Corcoran-Schwartz IM, Zhang W, Harcke T, Devereux WL, Baylin SB, Eberhart CG, Watkins DN.

Genes Dev. 2008 Mar 15;22(6):770-85. doi: 10.1101/gad.1640908. Erratum in: Genes Dev. 2008 May 15;22(10):1410.

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