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Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein.

Johnson JL, Monfregola J, Napolitano G, Kiosses WB, Catz SD.

Mol Biol Cell. 2012 May;23(10):1902-16. doi: 10.1091/mbc.E11-12-1001. Epub 2012 Mar 21.


Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes.

Munafó DB, Johnson JL, Ellis BA, Rutschmann S, Beutler B, Catz SD.

Biochem J. 2007 Mar 1;402(2):229-39.


The Rab27a effectors JFC1/Slp1 and Munc13-4 regulate exocytosis of neutrophil granules.

Brzezinska AA, Johnson JL, Munafo DB, Crozat K, Beutler B, Kiosses WB, Ellis BA, Catz SD.

Traffic. 2008 Dec;9(12):2151-64. doi: 10.1111/j.1600-0854.2008.00838.x. Epub 2008 Oct 30.


The Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membrane.

Wang H, Ishizaki R, Xu J, Kasai K, Kobayashi E, Gomi H, Izumi T.

Mol Biol Cell. 2013 Feb;24(3):319-30. doi: 10.1091/mbc.E12-04-0265. Epub 2012 Dec 5.


Munc13-4 restricts motility of Rab27a-expressing vesicles to facilitate lipopolysaccharide-induced priming of exocytosis in neutrophils.

Johnson JL, Hong H, Monfregola J, Kiosses WB, Catz SD.

J Biol Chem. 2011 Feb 18;286(7):5647-56. doi: 10.1074/jbc.M110.184762. Epub 2010 Dec 9.


Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation: DRUGGABILITY OF THE SMALL GTPase Rab27a.

Johnson JL, Ramadass M, He J, Brown SJ, Zhang J, Abgaryan L, Biris N, Gavathiotis E, Rosen H, Catz SD.

J Biol Chem. 2016 Dec 9;291(50):25965-25982. Epub 2016 Oct 4.


Rab27a and Rab27b regulate neutrophil azurophilic granule exocytosis and NADPH oxidase activity by independent mechanisms.

Johnson JL, Brzezinska AA, Tolmachova T, Munafo DB, Ellis BA, Seabra MC, Hong H, Catz SD.

Traffic. 2010 Apr;11(4):533-47. doi: 10.1111/j.1600-0854.2009.01029.x. Epub 2009 Dec 17.


Akt regulates the subcellular localization of the Rab27a-binding protein JFC1 by phosphorylation.

Johnson JL, Pacquelet S, Lane WS, Eam B, Catz SD.

Traffic. 2005 Aug;6(8):667-81.


Primary granule exocytosis in human neutrophils is regulated by Rac-dependent actin remodeling.

Mitchell T, Lo A, Logan MR, Lacy P, Eitzen G.

Am J Physiol Cell Physiol. 2008 Nov;295(5):C1354-65. doi: 10.1152/ajpcell.00239.2008. Epub 2008 Sep 17.


Exophilin8 transiently clusters insulin granules at the actin-rich cell cortex prior to exocytosis.

Mizuno K, Ramalho JS, Izumi T.

Mol Biol Cell. 2011 May 15;22(10):1716-26. doi: 10.1091/mbc.E10-05-0404. Epub 2011 Mar 25.


Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland.

Chiang L, Ngo J, Schechter JE, Karvar S, Tolmachova T, Seabra MC, Hume AN, Hamm-Alvarez SF.

Am J Physiol Cell Physiol. 2011 Aug;301(2):C507-21. doi: 10.1152/ajpcell.00355.2010. Epub 2011 Apr 27. Erratum in: Am J Physiol Cell Physiol. 2011 Dec;301(6):C1480.


Involvement of the Rab27 binding protein Slac2c/MyRIP in insulin exocytosis.

Waselle L, Coppola T, Fukuda M, Iezzi M, El-Amraoui A, Petit C, Regazzi R.

Mol Biol Cell. 2003 Oct;14(10):4103-13. Epub 2003 Aug 7.


Gem GTPase acts upstream Gmip/RhoA to regulate cortical actin remodeling and spindle positioning during early mitosis.

Andrieu G, Quaranta M, Leprince C, Cuvillier O, Hatzoglou A.

Carcinogenesis. 2014 Nov;35(11):2503-11. doi: 10.1093/carcin/bgu185. Epub 2014 Aug 30.


Interaction of the actin cytoskeleton with microtubules regulates secretory organelle movement near the plasma membrane in human endothelial cells.

Manneville JB, Etienne-Manneville S, Skehel P, Carter T, Ogden D, Ferenczi M.

J Cell Sci. 2003 Oct 1;116(Pt 19):3927-38. Epub 2003 Aug 19.


Munc13-4 Is a Rab11-binding Protein That Regulates Rab11-positive Vesicle Trafficking and Docking at the Plasma Membrane.

Johnson JL, He J, Ramadass M, Pestonjamasp K, Kiosses WB, Zhang J, Catz SD.

J Biol Chem. 2016 Feb 12;291(7):3423-38. doi: 10.1074/jbc.M115.705871. Epub 2015 Dec 4.


Rab27A and its effector MyRIP link secretory granules to F-actin and control their motion towards release sites.

Desnos C, Schonn JS, Huet S, Tran VS, El-Amraoui A, Raposo G, Fanget I, Chapuis C, Ménasché G, de Saint Basile G, Petit C, Cribier S, Henry JP, Darchen F.

J Cell Biol. 2003 Nov 10;163(3):559-70.


Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretion.

Singh RK, Mizuno K, Wasmeier C, Wavre-Shapton ST, Recchi C, Catz SD, Futter C, Tolmachova T, Hume AN, Seabra MC.

FEBS J. 2013 Feb;280(3):892-903. doi: 10.1111/febs.12081. Epub 2013 Jan 2.


Granuphilin modulates the exocytosis of secretory granules through interaction with syntaxin 1a.

Torii S, Zhao S, Yi Z, Takeuchi T, Izumi T.

Mol Cell Biol. 2002 Aug;22(15):5518-26.

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