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Items: 1 to 20 of 122

1.

HIV-1 and HIV-2 reverse transcriptases: different mechanisms of resistance to nucleoside reverse transcriptase inhibitors.

Boyer PL, Clark PK, Hughes SH.

J Virol. 2012 May;86(10):5885-94. doi: 10.1128/JVI.06597-11. Epub 2012 Mar 21.

2.
5.

Why do HIV-1 and HIV-2 use different pathways to develop AZT resistance?

Boyer PL, Sarafianos SG, Clark PK, Arnold E, Hughes SH.

PLoS Pathog. 2006 Feb;2(2):e10. Epub 2006 Feb 17.

6.

Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase.

Boyer PL, Sarafianos SG, Arnold E, Hughes SH.

J Virol. 2001 May;75(10):4832-42.

7.

Analysis of the Zidovudine Resistance Mutations T215Y, M41L, and L210W in HIV-1 Reverse Transcriptase.

Boyer PL, Das K, Arnold E, Hughes SH.

Antimicrob Agents Chemother. 2015 Dec;59(12):7184-96. doi: 10.1128/AAC.05069-14. Epub 2015 Aug 31.

9.

Non-nucleoside inhibitors of HIV-1 reverse transcriptase inhibit phosphorolysis and resensitize the 3'-azido-3'-deoxythymidine (AZT)-resistant polymerase to AZT-5'-triphosphate.

Odriozola L, Cruchaga C, Andréola M, Dollé V, Nguyen CH, Tarrago-Litvak L, Pérez-Mediavilla A, Martínez-Irujo JJ.

J Biol Chem. 2003 Oct 24;278(43):42710-6. Epub 2003 Aug 13.

10.
11.

The K65R reverse transcriptase mutation in HIV-1 reverses the excision phenotype of zidovudine resistance mutations.

White KL, Chen JM, Feng JY, Margot NA, Ly JK, Ray AS, Macarthur HL, McDermott MJ, Swaminathan S, Miller MD.

Antivir Ther. 2006;11(2):155-63.

PMID:
16640096
12.

Structural basis of HIV-1 resistance to AZT by excision.

Tu X, Das K, Han Q, Bauman JD, Clark AD Jr, Hou X, Frenkel YV, Gaffney BL, Jones RA, Boyer PL, Hughes SH, Sarafianos SG, Arnold E.

Nat Struct Mol Biol. 2010 Oct;17(10):1202-9. doi: 10.1038/nsmb.1908. Epub 2010 Sep 19.

13.

Molecular mechanism by which the K70E mutation in human immunodeficiency virus type 1 reverse transcriptase confers resistance to nucleoside reverse transcriptase inhibitors.

Sluis-Cremer N, Sheen CW, Zelina S, Torres PS, Parikh UM, Mellors JW.

Antimicrob Agents Chemother. 2007 Jan;51(1):48-53. Epub 2006 Nov 6.

15.

Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors.

Schneider A, Corona A, Spöring I, Jordan M, Buchholz B, Maccioni E, Di Santo R, Bodem J, Tramontano E, Wöhrl BM.

Nucleic Acids Res. 2016 Mar 18;44(5):2310-22. doi: 10.1093/nar/gkw060. Epub 2016 Feb 4.

16.

Single-step kinetics of HIV-1 reverse transcriptase mutants responsible for virus resistance to nucleoside inhibitors zidovudine and 3-TC.

Krebs R, Immendörfer U, Thrall SH, Wöhrl BM, Goody RS.

Biochemistry. 1997 Aug 19;36(33):10292-300.

PMID:
9254628
17.
19.

The emergence of different resistance mechanisms toward nucleoside inhibitors is explained by the properties of the wild type HIV-1 reverse transcriptase.

Isel C, Ehresmann C, Walter P, Ehresmann B, Marquet R.

J Biol Chem. 2001 Dec 28;276(52):48725-32. Epub 2001 Oct 19.

20.

The balance between NRTI discrimination and excision drives the susceptibility of HIV-1 RT mutants K65R, M184V and K65r+M184V.

Ly JK, Margot NA, MacArthur HL, Hung M, Miller MD, White KL.

Antivir Chem Chemother. 2007;18(6):307-16.

PMID:
18320935

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