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Items: 1 to 20 of 171

1.

Synthesis of new sulfonamides as lipoxygenase inhibitors.

Mustafa G, Khan IU, Ashraf M, Afzal I, Shahzad SA, Shafiq M.

Bioorg Med Chem. 2012 Apr 15;20(8):2535-9. doi: 10.1016/j.bmc.2012.02.055. Epub 2012 Mar 3.

PMID:
22436389
2.

Syntheses and characterization of nimesulide derivatives for dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase.

Li Y, Chen SH, Ou TM, Tan JH, Li D, Gu LQ, Huang ZS.

Bioorg Med Chem. 2011 Mar 15;19(6):2074-83. doi: 10.1016/j.bmc.2011.01.043. Epub 2011 Feb 1.

PMID:
21349729
3.

Design and synthesis of eugenol derivatives, as potent 15-lipoxygenase inhibitors.

Sadeghian H, Seyedi SM, Saberi MR, Arghiani Z, Riazi M.

Bioorg Med Chem. 2008 Jan 15;16(2):890-901. Epub 2007 Oct 12.

PMID:
17998164
4.

Modified acidic nonsteroidal anti-inflammatory drugs as dual inhibitors of mPGES-1 and 5-LOX.

Elkady M, Nieß R, Schaible AM, Bauer J, Luderer S, Ambrosi G, Werz O, Laufer SA.

J Med Chem. 2012 Oct 25;55(20):8958-62. doi: 10.1021/jm3010543. Epub 2012 Oct 9.

PMID:
22992107
5.

Design, synthesis, and biological evaluation of prenylated chalcones as 5-LOX inhibitors.

Reddy NP, Aparoy P, Reddy TC, Achari C, Sridhar PR, Reddanna P.

Bioorg Med Chem. 2010 Aug 15;18(16):5807-15. doi: 10.1016/j.bmc.2010.06.107. Epub 2010 Jul 6.

PMID:
20667741
6.

Anacardic acid derived salicylates are inhibitors or activators of lipoxygenases.

Wisastra R, Ghizzoni M, Boltjes A, Haisma HJ, Dekker FJ.

Bioorg Med Chem. 2012 Aug 15;20(16):5027-32. doi: 10.1016/j.bmc.2012.06.019. Epub 2012 Jun 21.

PMID:
22789707
7.
8.

Pyrazole-based sulfonamide and sulfamides as potent inhibitors of mammalian 15-lipoxygenase.

Ngu K, Weinstein DS, Liu W, Langevine C, Combs DW, Zhuang S, Chen X, Madsen CS, Harper TW, Ahmad S, Robl JA.

Bioorg Med Chem Lett. 2011 Jul 15;21(14):4141-5. doi: 10.1016/j.bmcl.2011.05.107. Epub 2011 Jun 6.

PMID:
21696952
9.

Synthesis, characterization and biological screening of sulfonamides derived form 2-phenylethylamine.

Rehman AU, Afroz S, Abbasi MA, Tanveer W, Khan KM, Ashraf M, Ahmad I, Afzal I, Ambreen N.

Pak J Pharm Sci. 2012 Oct;25(4):809-14.

PMID:
23009998
10.

Synthesis and 5-lipoxygenase inhibitory activity of new cinnamoyl and caffeoyl clusters.

Doiron J, Boudreau LH, Picot N, Villebonet B, Surette ME, Touaibia M.

Bioorg Med Chem Lett. 2009 Feb 15;19(4):1118-21. doi: 10.1016/j.bmcl.2008.12.108. Epub 2009 Jan 3.

PMID:
19152786
11.

Structure based drug design, synthesis and evaluation of 4-(benzyloxy)-1-phenylbut-2-yn-1-ol derivatives as 5-lipoxygenase inhibitors.

Reddy NP, Chandramohan Reddy T, Aparoy P, Achari C, Sridhar PR, Reddanna P.

Eur J Med Chem. 2012 Jan;47(1):351-9. doi: 10.1016/j.ejmech.2011.11.003. Epub 2011 Nov 10.

PMID:
22118829
12.

Synthesis, spectral characterization and enzyme inhibition studies of different chlorinated sulfonamides.

Rehman AU, Abbasi MA, Rasool S, Ashraf M, Ejaz SA, Hassan R, Khalid N.

Pak J Pharm Sci. 2014 Nov;27(6):1739-45.

PMID:
25362587
13.

Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.

Chowdhury MA, Abdellatif KR, Dong Y, Das D, Suresh MR, Knaus EE.

Bioorg Med Chem Lett. 2008 Dec 1;18(23):6138-41. doi: 10.1016/j.bmcl.2008.10.009. Epub 2008 Oct 7.

PMID:
18945614
14.

Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors.

Song H, Oh SR, Lee HK, Han G, Kim JH, Chang HW, Doh KE, Rhee HK, Choo HY.

Bioorg Med Chem. 2010 Nov 1;18(21):7580-5. doi: 10.1016/j.bmc.2010.08.047. Epub 2010 Oct 1.

PMID:
20870413
15.

Synthesis and biological evaluation of N-difluoromethyl-1,2-dihydropyrid-2-one acetic acid regioisomers: dual inhibitors of cyclooxygenases and 5-lipoxygenase.

Yu G, Praveen Rao PN, Chowdhury MA, Abdellatif KR, Dong Y, Das D, Velázquez CA, Suresh MR, Knaus EE.

Bioorg Med Chem Lett. 2010 Apr 1;20(7):2168-73. doi: 10.1016/j.bmcl.2010.02.040. Epub 2010 Feb 13.

PMID:
20202839
16.

Synthesis and SAR studies of 3-allyl-4-prenyloxyaniline amides as potent 15-lipoxygenase inhibitors.

Jabbari A, Davoodnejad M, Alimardani M, Assadieskandar A, Sadeghian A, Safdari H, Movaffagh J, Sadeghian H.

Bioorg Med Chem. 2012 Sep 15;20(18):5518-26. doi: 10.1016/j.bmc.2012.07.025. Epub 2012 Jul 24.

PMID:
22917856
17.

N-(5-substituted) thiophene-2-alkylsulfonamides as potent inhibitors of 5-lipoxygenase.

Beers SA, Malloy EA, Wu W, Wachter M, Ansell J, Singer M, Steber M, Barbone A, Kirchner T, Ritchie D, Argentieri D.

Bioorg Med Chem. 1997 Apr;5(4):779-86.

PMID:
9158876
18.

Synthesis and biological evaluation of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.

Chowdhury MA, Abdellatif KR, Dong Y, Das D, Yu G, Velázquez CA, Suresh MR, Knaus EE.

Bioorg Med Chem Lett. 2009 Dec 15;19(24):6855-61. doi: 10.1016/j.bmcl.2009.10.083. Epub 2009 Oct 23.

PMID:
19884005
19.

SAR-study on a new class of imidazo[1,2-a]pyridine-based inhibitors of 5-lipoxygenase.

Hieke M, Rödl CB, Wisniewska JM, la Buscató E, Stark H, Schubert-Zsilavecz M, Steinhilber D, Hofmann B, Proschak E.

Bioorg Med Chem Lett. 2012 Mar 1;22(5):1969-75. doi: 10.1016/j.bmcl.2012.01.038. Epub 2012 Jan 24.

PMID:
22326163
20.

Synthesis and biological evaluation of a class of 5-benzylidene-2-phenyl-thiazolinones as potent 5-lipoxygenase inhibitors.

Barzen S, Rödl CB, Lill A, Steinhilber D, Stark H, Hofmann B.

Bioorg Med Chem. 2012 Jun 1;20(11):3575-83. doi: 10.1016/j.bmc.2012.04.003. Epub 2012 Apr 11.

PMID:
22551629

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