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Items: 1 to 20 of 97

1.

LYP inhibits T-cell activation when dissociated from CSK.

Vang T, Liu WH, Delacroix L, Wu S, Vasile S, Dahl R, Yang L, Musumeci L, Francis D, Landskron J, Tasken K, Tremblay ML, Lie BA, Page R, Mustelin T, Rahmouni S, Rickert RC, Tautz L.

Nat Chem Biol. 2012 Mar 18;8(5):437-46. doi: 10.1038/nchembio.916.

2.

The autoimmunity risk variant LYP-W620 cooperates with CSK in the regulation of TCR signaling.

de la Puerta ML, Trinidad AG, Rodríguez Mdel C, de Pereda JM, Sánchez Crespo M, Bayón Y, Alonso A.

PLoS One. 2013;8(1):e54569. doi: 10.1371/journal.pone.0054569.

3.

Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue.

Fiorillo E, Orrú V, Stanford SM, Liu Y, Salek M, Rapini N, Schenone AD, Saccucci P, Delogu LG, Angelini F, Manca Bitti ML, Schmedt C, Chan AC, Acuto O, Bottini N.

J Biol Chem. 2010 Aug 20;285(34):26506-18. doi: 10.1074/jbc.M110.111104.

4.

Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases.

Yu X, Sun JP, He Y, Guo X, Liu S, Zhou B, Hudmon A, Zhang ZY.

Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19767-72.

5.
6.

Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells.

Wu DJ, Zhou W, Enouz S, Orrú V, Stanford SM, Maine CJ, Rapini N, Sawatzke K, Engel I, Fiorillo E, Sherman LA, Kronenberg M, Zehn D, Peterson E, Bottini N.

PLoS One. 2014 Feb 3;9(2):e86677. doi: 10.1371/journal.pone.0086677.

7.

Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor.

Vang T, Torgersen KM, Sundvold V, Saxena M, Levy FO, Skålhegg BS, Hansson V, Mustelin T, Taskén K.

J Exp Med. 2001 Feb 19;193(4):497-507.

8.

Immunology: Csk keeps LYP on a leash.

Zhong MC, Veillette A.

Nat Chem Biol. 2012 Apr 17;8(5):412-3. doi: 10.1038/nchembio.940. No abstract available.

PMID:
22510660
9.

Lymphoid-specific tyrosine phosphatase (Lyp): a potential drug target for treatment of autoimmune diseases.

Du J, Qiao Y, Sun L, Wang X.

Curr Drug Targets. 2014 Mar;15(3):335-46. Review.

PMID:
24188455
10.

The autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses.

Vang T, Landskron J, Viken MK, Oberprieler N, Torgersen KM, Mustelin T, Tasken K, Tautz L, Rickert RC, Lie BA.

Hum Immunol. 2013 May;74(5):574-85. doi: 10.1016/j.humimm.2012.12.017.

11.

Biochemical and functional studies of lymphoid-specific tyrosine phosphatase (Lyp) variants S201F and R266W.

Liu J, Chen M, Li R, Yang F, Shi X, Zhu L, Wang HM, Yao W, Liu Q, Meng FG, Sun JP, Pang Q, Yu X.

PLoS One. 2012;7(8):e43631. doi: 10.1371/journal.pone.0043631.

12.
13.

Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation.

Brdicka T, Pavlistová D, Leo A, Bruyns E, Korínek V, Angelisová P, Scherer J, Shevchenko A, Hilgert I, Cerný J, Drbal K, Kuramitsu Y, Kornacker B, Horejsí V, Schraven B.

J Exp Med. 2000 May 1;191(9):1591-604.

14.

The effects of membrane compartmentalization of csk on TCR signaling.

Otáhal P, Pata S, Angelisová P, Hořejší V, Brdička T.

Biochim Biophys Acta. 2011 Feb;1813(2):367-76. doi: 10.1016/j.bbamcr.2010.12.003.

15.

Knockdown of C-terminal Src kinase by siRNA-mediated RNA interference augments T cell receptor signaling in mature T cells.

Vang T, Abrahamsen H, Myklebust S, Enserink J, Prydz H, Mustelin T, Amarzguioui M, Tasken K.

Eur J Immunol. 2004 Aug;34(8):2191-9.

16.

Combined spatial and enzymatic regulation of Csk by cAMP and protein kinase a inhibits T cell receptor signaling.

Vang T, Abrahamsen H, Myklebust S, Horejsí V, Taskén K.

J Biol Chem. 2003 May 16;278(20):17597-600.

17.

Removal of C-terminal SRC kinase from the immune synapse by a new binding protein.

Rahmouni S, Vang T, Alonso A, Williams S, van Stipdonk M, Soncini C, Moutschen M, Schoenberger SP, Mustelin T.

Mol Cell Biol. 2005 Mar;25(6):2227-41.

18.

The putative role of the C1858T polymorphism of protein tyrosine phosphatase PTPN22 gene in autoimmunity.

Gianchecchi E, Palombi M, Fierabracci A.

Autoimmun Rev. 2013 May;12(7):717-25. doi: 10.1016/j.autrev.2012.12.003. Review.

PMID:
23261816
19.

CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation.

Manjarrez-Orduño N, Marasco E, Chung SA, Katz MS, Kiridly JF, Simpfendorfer KR, Freudenberg J, Ballard DH, Nashi E, Hopkins TJ, Cunninghame Graham DS, Lee AT, Coenen MJ, Franke B, Swinkels DW, Graham RR, Kimberly RP, Gaffney PM, Vyse TJ, Behrens TW, Criswell LA, Diamond B, Gregersen PK.

Nat Genet. 2012 Nov;44(11):1227-30. doi: 10.1038/ng.2439.

20.

Inhibition of lymphoid tyrosine phosphatase by benzofuran salicylic acids.

Vang T, Xie Y, Liu WH, Vidović D, Liu Y, Wu S, Smith DH, Rinderspacher A, Chung C, Gong G, Mustelin T, Landry DW, Rickert RC, Schürer SC, Deng SX, Tautz L.

J Med Chem. 2011 Jan 27;54(2):562-71. doi: 10.1021/jm101004d.

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