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Items: 1 to 20 of 104

1.

Low perforin expression of early differentiated HCV-specific CD8+ T cells limits their hepatotoxic potential.

Jo J, Bengsch B, Seigel B, Rau SJ, Schmidt J, Bisse E, Aichele P, Aichele U, Joeckel L, Royer C, Sá Ferreira K, Borner C, Baumert TF, Blum HE, Lohmann V, Fischer R, Thimme R.

J Hepatol. 2012 Jul;57(1):9-16. doi: 10.1016/j.jhep.2012.02.030. Epub 2012 Mar 14.

PMID:
22425625
2.

Dysfunction and functional restoration of HCV-specific CD8 responses in chronic hepatitis C virus infection.

Penna A, Pilli M, Zerbini A, Orlandini A, Mezzadri S, Sacchelli L, Missale G, Ferrari C.

Hepatology. 2007 Mar;45(3):588-601.

PMID:
17326153
3.

Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection.

Wedemeyer H, He XS, Nascimbeni M, Davis AR, Greenberg HB, Hoofnagle JH, Liang TJ, Alter H, Rehermann B.

J Immunol. 2002 Sep 15;169(6):3447-58.

4.

Features and distribution of CD8 T cells with human leukocyte antigen class I-specific receptor expression in chronic hepatitis C.

Bonorino P, Leroy V, Dufeu-Duchesne T, Tongiani-Dashan S, Sturm N, Pernollet M, Vivier E, Zarski JP, Marche PN, Jouvin-Marche E.

Hepatology. 2007 Nov;46(5):1375-86.

PMID:
17668887
5.

Accumulation of dysfunctional effector CD8+ T cells in the liver of patients with chronic HCV infection.

Nisii C, Tempestilli M, Agrati C, Poccia F, Tocci G, Longo MA, D'Offizi G, Tersigni R, Lo Iacono O, Antonucci G, Oliva A.

J Hepatol. 2006 Mar;44(3):475-83. Epub 2005 Dec 5.

PMID:
16426698
6.

Differential expression of perforin and granzyme B in the liver of patients with chronic hepatitis C.

Pham BN, Martinot-Peignoux M, Valla D, Dubois S, Degott C, Mosnier JF.

Hum Pathol. 2003 Aug;34(8):770-7.

PMID:
14506637
7.

Quantitative and functional differences in CD8+ lymphocyte responses in resolved acute and chronic hepatitis C virus infection.

Lancaster T, Sanders E, Christie JM, Brooks C, Green S, Rosenberg WM.

J Viral Hepat. 2002 Jan;9(1):18-28.

PMID:
11851899
8.

Pervasive influence of hepatitis C virus on the phenotype of antiviral CD8+ T cells.

Lucas M, Vargas-Cuero AL, Lauer GM, Barnes E, Willberg CB, Semmo N, Walker BD, Phillips R, Klenerman P.

J Immunol. 2004 Feb 1;172(3):1744-53.

9.

Most antiviral CD8 T cells during chronic viral infection do not express high levels of perforin and are not directly cytotoxic.

Zhang D, Shankar P, Xu Z, Harnisch B, Chen G, Lange C, Lee SJ, Valdez H, Lederman MM, Lieberman J.

Blood. 2003 Jan 1;101(1):226-35. Epub 2002 Aug 22.

10.

Differential CD4(+) and CD8(+) T-cell responsiveness in hepatitis C virus infection.

Chang KM, Thimme R, Melpolder JJ, Oldach D, Pemberton J, Moorhead-Loudis J, McHutchison JG, Alter HJ, Chisari FV.

Hepatology. 2001 Jan;33(1):267-76.

PMID:
11124845
11.

T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection.

Boettler T, Spangenberg HC, Neumann-Haefelin C, Panther E, Urbani S, Ferrari C, Blum HE, von Weizsäcker F, Thimme R.

J Virol. 2005 Jun;79(12):7860-7.

12.

CD161 expression on hepatitis C virus-specific CD8+ T cells suggests a distinct pathway of T cell differentiation.

Northfield JW, Kasprowicz V, Lucas M, Kersting N, Bengsch B, Kim A, Phillips RE, Walker BD, Thimme R, Lauer G, Klenerman P.

Hepatology. 2008 Feb;47(2):396-406. doi: 10.1002/hep.22040. Erratum in: Hepatology. 2008 Mar;47(3):1102. Bengsh, Bertram [corrected to Bengsch, Bertram].

PMID:
18219672
13.

Intrahepatic virus-specific IL-10-producing CD8 T cells prevent liver damage during chronic hepatitis C virus infection.

Abel M, Sène D, Pol S, Bourlière M, Poynard T, Charlotte F, Cacoub P, Caillat-Zucman S.

Hepatology. 2006 Dec;44(6):1607-16.

PMID:
17133491
14.

Regulatory T cells suppress in vitro proliferation of virus-specific CD8+ T cells during persistent hepatitis C virus infection.

Rushbrook SM, Ward SM, Unitt E, Vowler SL, Lucas M, Klenerman P, Alexander GJ.

J Virol. 2005 Jun;79(12):7852-9.

15.

Virally infected hepatocytes are resistant to perforin-dependent CTL effector mechanisms.

Kafrouni MI, Brown GR, Thiele DL.

J Immunol. 2001 Aug 1;167(3):1566-74.

16.

Increase in activated CD8+ T lymphocytes expressing perforin and granzyme B correlates with disease activity in patients with systemic lupus erythematosus.

Blanco P, Pitard V, Viallard JF, Taupin JL, Pellegrin JL, Moreau JF.

Arthritis Rheum. 2005 Jan;52(1):201-11.

17.

Elevated numbers of Fc gamma RIIIA+ (CD16+) effector CD8 T cells with NK cell-like function in chronic hepatitis C virus infection.

Björkström NK, Gonzalez VD, Malmberg KJ, Falconer K, Alaeus A, Nowak G, Jorns C, Ericzon BG, Weiland O, Sandberg JK, Ljunggren HG.

J Immunol. 2008 Sep 15;181(6):4219-28.

18.

Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver.

Bengsch B, Spangenberg HC, Kersting N, Neumann-Haefelin C, Panther E, von Weizsäcker F, Blum HE, Pircher H, Thimme R.

J Virol. 2007 Jan;81(2):945-53. Epub 2006 Nov 1.

19.

Cytotoxic CD4 T cells in viral hepatitis.

Aslan N, Yurdaydin C, Wiegand J, Greten T, Ciner A, Meyer MF, Heiken H, Kuhlmann B, Kaiser T, Bozkaya H, Tillmann HL, Bozdayi AM, Manns MP, Wedemeyer H.

J Viral Hepat. 2006 Aug;13(8):505-14.

PMID:
16901280
20.

Factors that determine the antiviral efficacy of HCV-specific CD8(+) T cells ex vivo.

Seigel B, Bengsch B, Lohmann V, Bartenschlager R, Blum HE, Thimme R.

Gastroenterology. 2013 Feb;144(2):426-36. doi: 10.1053/j.gastro.2012.10.047. Epub 2012 Nov 7.

PMID:
23142136

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