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Conditional activation of β-catenin signaling in mice leads to severe defects in intervertebral disc tissue.

Wang M, Tang D, Shu B, Wang B, Jin H, Hao S, Dresser KA, Shen J, Im HJ, Sampson ER, Rubery PT, Zuscik MJ, Schwarz EM, O'Keefe RJ, Wang Y, Chen D.

Arthritis Rheum. 2012 Aug;64(8):2611-23. doi: 10.1002/art.34469.


Activation of β-catenin signalling leads to temporomandibular joint defects.

Wang M, Li S, Xie W, Shen J, Im HJ, Holz JD, Wang M, Diekwisch TG, Chen D.

Eur Cell Mater. 2014 Oct 23;28:223-35.


Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice.

Zhu M, Tang D, Wu Q, Hao S, Chen M, Xie C, Rosier RN, O'Keefe RJ, Zuscik M, Chen D.

J Bone Miner Res. 2009 Jan;24(1):12-21. doi: 10.1359/jbmr.080901.


Role of β-catenin signaling in intervertebral disc degeneration: comment on the article by Wang et al.

Li X, Zhao QY, Yuan FL.

Arthritis Rheum. 2012 Sep;64(9):3054; author reply 3054-5. doi: 10.1002/art.34578. No abstract available.


Enhancement of Runx2 expression is potentially linked to β-catenin accumulation in canine intervertebral disc degeneration.

Iwata M, Aikawa T, Hakozaki T, Arai K, Ochi H, Haro H, Tagawa M, Asou Y, Hara Y.

J Cell Physiol. 2015 Jan;230(1):180-90. doi: 10.1002/jcp.24697.


Ectopic expression of Smurf2 and acceleration of age-related intervertebral disc degeneration in a mouse model.

Wu Q, Huang JH.

J Neurosurg Spine. 2017 Jul;27(1):116-126. doi: 10.3171/2016.11.SPINE16901. Epub 2017 Apr 7.


Enhancement of intervertebral disc cell senescence by WNT/β-catenin signaling-induced matrix metalloproteinase expression.

Hiyama A, Sakai D, Risbud MV, Tanaka M, Arai F, Abe K, Mochida J.

Arthritis Rheum. 2010 Oct;62(10):3036-47. doi: 10.1002/art.27599.


Specific inhibitory protein Dkk-1 blocking Wnt/β-catenin signaling pathway improve protectives effect on the extracellular matrix.

Ye S, Wang J, Yang S, Xu W, Xie M, Han K, Zhang B, Wu Z.

J Huazhong Univ Sci Technolog Med Sci. 2011 Oct;31(5):657-62. doi: 10.1007/s11596-011-0577-y. Epub 2011 Oct 25.


TGF-β signaling plays an essential role in the growth and maintenance of intervertebral disc tissue.

Jin H, Shen J, Wang B, Wang M, Shu B, Chen D.

FEBS Lett. 2011 Apr 20;585(8):1209-15. doi: 10.1016/j.febslet.2011.03.034. Epub 2011 Mar 21.


Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification.

Tamamura Y, Otani T, Kanatani N, Koyama E, Kitagaki J, Komori T, Yamada Y, Costantini F, Wakisaka S, Pacifici M, Iwamoto M, Enomoto-Iwamoto M.

J Biol Chem. 2005 May 13;280(19):19185-95. Epub 2005 Mar 10.


Prolonged upright posture induces degenerative changes in intervertebral discs in rat lumbar spine.

Liang QQ, Zhou Q, Zhang M, Hou W, Cui XJ, Li CG, Li TF, Shi Q, Wang YJ.

Spine (Phila Pa 1976). 2008 Sep 1;33(19):2052-8. doi: 10.1097/BRS.0b013e318183f949.


Intervertebral disc development is regulated by Wnt/β-catenin signaling.

Kondo N, Yuasa T, Shimono K, Tung W, Okabe T, Yasuhara R, Pacifici M, Zhang Y, Iwamoto M, Enomoto-Iwamoto M.

Spine (Phila Pa 1976). 2011 Apr 15;36(8):E513-8. doi: 10.1097/BRS.0b013e3181f52cb5.


Intermittent cyclic mechanical tension promotes endplate cartilage degeneration via canonical Wnt signaling pathway and E-cadherin/β-catenin complex cross-talk.

Xu HG, Zheng Q, Song JX, Li J, Wang H, Liu P, Wang J, Wang CD, Zhang XL.

Osteoarthritis Cartilage. 2016 Jan;24(1):158-68. doi: 10.1016/j.joca.2015.07.019. Epub 2015 Aug 3.


The relationship between the Wnt/β-catenin and TGF-β/BMP signals in the intervertebral disc cell.

Hiyama A, Sakai D, Tanaka M, Arai F, Nakajima D, Abe K, Mochida J.

J Cell Physiol. 2011 May;226(5):1139-48. doi: 10.1002/jcp.22438.


Prolonged upright posture induces degenerative changes in intervertebral discs of rat cervical spine.

Liang QQ, Cui XJ, Xi ZJ, Bian Q, Hou W, Zhao YJ, Shi Q, Wang YJ.

Spine (Phila Pa 1976). 2011 Jan 1;36(1):E14-9. doi: 10.1097/BRS.0b013e3181d2dec2.


Impaired intervertebral disc development and premature disc degeneration in mice with notochord-specific deletion of CCN2.

Bedore J, Sha W, McCann MR, Liu S, Leask A, Séguin CA.

Arthritis Rheum. 2013 Oct;65(10):2634-44. doi: 10.1002/art.38075.


Progranulin knockout accelerates intervertebral disc degeneration in aging mice.

Zhao YP, Tian QY, Liu B, Cuellar J, Richbourgh B, Jia TH, Liu CJ.

Sci Rep. 2015 Mar 16;5:9102. doi: 10.1038/srep09102.


Anabolic effects of Peniel 2000, a peptide that regulates TGF-β1 signaling on intervertebral disc degeneration.

Kwon YJ, Lee JW, Moon EJ, Chung YG, Kim OS, Kim HJ.

Spine (Phila Pa 1976). 2013 Jan 15;38(2):E49-58. doi: 10.1097/BRS.0b013e31827aa896.


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