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Items: 1 to 20 of 133

1.

Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation.

Van Aller GS, Reynoird N, Barbash O, Huddleston M, Liu S, Zmoos AF, McDevitt P, Sinnamon R, Le B, Mas G, Annan R, Sage J, Garcia BA, Tummino PJ, Gozani O, Kruger RG.

Epigenetics. 2012 Apr;7(4):340-3. doi: 10.4161/epi.19506. Epub 2012 Apr 1.

2.

SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells.

Hamamoto R, Furukawa Y, Morita M, Iimura Y, Silva FP, Li M, Yagyu R, Nakamura Y.

Nat Cell Biol. 2004 Aug;6(8):731-40. Epub 2004 Jul 4.

3.

Requirement of histone methyltransferase SMYD3 for estrogen receptor-mediated transcription.

Kim H, Heo K, Kim JH, Kim K, Choi J, An W.

J Biol Chem. 2009 Jul 24;284(30):19867-77. doi: 10.1074/jbc.M109.021485. Epub 2009 Jun 9.

4.

Lysine methylation in cancer: SMYD3-MAP3K2 teaches us new lessons in the Ras-ERK pathway.

Colón-Bolea P, Crespo P.

Bioessays. 2014 Dec;36(12):1162-9. doi: 10.1002/bies.201400120. Epub 2014 Sep 2. Review.

PMID:
25382779
5.

The lysine 831 of vascular endothelial growth factor receptor 1 is a novel target of methylation by SMYD3.

Kunizaki M, Hamamoto R, Silva FP, Yamaguchi K, Nagayasu T, Shibuya M, Nakamura Y, Furukawa Y.

Cancer Res. 2007 Nov 15;67(22):10759-65.

6.

Structural Basis for Substrate Preference of SMYD3, a SET Domain-containing Protein Lysine Methyltransferase.

Fu W, Liu N, Qiao Q, Wang M, Min J, Zhu B, Xu RM, Yang N.

J Biol Chem. 2016 Apr 22;291(17):9173-80. doi: 10.1074/jbc.M115.709832. Epub 2016 Feb 29.

7.

SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer.

Mazur PK, Reynoird N, Khatri P, Jansen PW, Wilkinson AW, Liu S, Barbash O, Van Aller GS, Huddleston M, Dhanak D, Tummino PJ, Kruger RG, Garcia BA, Butte AJ, Vermeulen M, Sage J, Gozani O.

Nature. 2014 Jun 12;510(7504):283-7. doi: 10.1038/nature13320. Epub 2014 May 21.

8.

Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation.

Popovic R, Martinez-Garcia E, Giannopoulou EG, Zhang Q, Zhang Q, Ezponda T, Shah MY, Zheng Y, Will CM, Small EC, Hua Y, Bulic M, Jiang Y, Carrara M, Calogero RA, Kath WL, Kelleher NL, Wang JP, Elemento O, Licht JD.

PLoS Genet. 2014 Sep 4;10(9):e1004566. doi: 10.1371/journal.pgen.1004566. eCollection 2014 Sep.

9.

Preferential dimethylation of histone H4 lysine 20 by Suv4-20.

Yang H, Pesavento JJ, Starnes TW, Cryderman DE, Wallrath LL, Kelleher NL, Mizzen CA.

J Biol Chem. 2008 May 2;283(18):12085-92. doi: 10.1074/jbc.M707974200. Epub 2008 Feb 21.

10.

Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses.

Green EM, Mas G, Young NL, Garcia BA, Gozani O.

Nat Struct Mol Biol. 2012 Feb 19;19(3):361-3. doi: 10.1038/nsmb.2252.

11.

SMYD3 promotes cancer invasion by epigenetic upregulation of the metalloproteinase MMP-9.

Cock-Rada AM, Medjkane S, Janski N, Yousfi N, Perichon M, Chaussepied M, Chluba J, Langsley G, Weitzman JB.

Cancer Res. 2012 Feb 1;72(3):810-20. doi: 10.1158/0008-5472.CAN-11-1052. Epub 2011 Dec 22.

12.

NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming.

Kuo AJ, Cheung P, Chen K, Zee BM, Kioi M, Lauring J, Xi Y, Park BH, Shi X, Garcia BA, Li W, Gozani O.

Mol Cell. 2011 Nov 18;44(4):609-20. doi: 10.1016/j.molcel.2011.08.042.

13.

PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin.

Nishioka K, Rice JC, Sarma K, Erdjument-Bromage H, Werner J, Wang Y, Chuikov S, Valenzuela P, Tempst P, Steward R, Lis JT, Allis CD, Reinberg D.

Mol Cell. 2002 Jun;9(6):1201-13.

14.

The telomerase reverse transcriptase (hTERT) gene is a direct target of the histone methyltransferase SMYD3.

Liu C, Fang X, Ge Z, Jalink M, Kyo S, Björkholm M, Gruber A, Sjöberg J, Xu D.

Cancer Res. 2007 Mar 15;67(6):2626-31.

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17.

Histone-modifier gene expression profiles are associated with pathological and clinical outcomes in human breast cancer.

Patani N, Jiang WG, Newbold RF, Mokbel K.

Anticancer Res. 2011 Dec;31(12):4115-25.

PMID:
22199269
18.

Regulation of estrogen receptor α by histone methyltransferase SMYD2-mediated protein methylation.

Zhang X, Tanaka K, Yan J, Li J, Peng D, Jiang Y, Yang Z, Barton MC, Wen H, Shi X.

Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17284-9. doi: 10.1073/pnas.1307959110. Epub 2013 Oct 7.

19.

Smyd3 open & closed lock mechanism for substrate recruitment: The hinge motion of C-terminal domain inferred from μ-second molecular dynamics simulations.

Chandramouli B, Silvestri V, Scarno M, Ottini L, Chillemi G.

Biochim Biophys Acta. 2016 Jul;1860(7):1466-74. doi: 10.1016/j.bbagen.2016.04.006. Epub 2016 Apr 13.

PMID:
27085704
20.

Specificity of protein lysine methyltransferases and methods for detection of lysine methylation of non-histone proteins.

Rathert P, Dhayalan A, Ma H, Jeltsch A.

Mol Biosyst. 2008 Dec;4(12):1186-90. doi: 10.1039/b811673c. Epub 2008 Oct 20. Review.

PMID:
19396382

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