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G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer.

Dong C, Wu Y, Yao J, Wang Y, Yu Y, Rychahou PG, Evers BM, Zhou BP.

J Clin Invest. 2012 Apr;122(4):1469-86. doi: 10.1172/JCI57349. Epub 2012 Mar 12.


Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer.

Dong C, Wu Y, Wang Y, Wang C, Kang T, Rychahou PG, Chi YI, Evers BM, Zhou BP.

Oncogene. 2013 Mar 14;32(11):1351-62. doi: 10.1038/onc.2012.169. Epub 2012 May 7.


The H3K9 Methyltransferase G9a Represses E-cadherin and is Associated with Myometrial Invasion in Endometrial Cancer.

Hsiao SM, Chen MW, Chen CA, Chien MH, Hua KT, Hsiao M, Kuo ML, Wei LH.

Ann Surg Oncol. 2015 Dec;22 Suppl 3:S1556-65. doi: 10.1245/s10434-015-4379-5. Epub 2015 Jan 23.


G9a is essential for EMT-mediated metastasis and maintenance of cancer stem cell-like characters in head and neck squamous cell carcinoma.

Liu S, Ye D, Guo W, Yu W, He Y, Hu J, Wang Y, Zhang L, Liao Y, Song H, Zhong S, Xu D, Yin H, Sun B, Wang X, Liu J, Wu Y, Zhou BP, Zhang Z, Deng J.

Oncotarget. 2015 Mar 30;6(9):6887-901.


δEF1 associates with DNMT1 and maintains DNA methylation of the E-cadherin promoter in breast cancer cells.

Fukagawa A, Ishii H, Miyazawa K, Saitoh M.

Cancer Med. 2015 Jan;4(1):125-35. doi: 10.1002/cam4.347. Epub 2014 Oct 15.


Hypoxic silencing of tumor suppressor RUNX3 by histone modification in gastric cancer cells.

Lee SH, Kim J, Kim WH, Lee YM.

Oncogene. 2009 Jan 15;28(2):184-94. doi: 10.1038/onc.2008.377. Epub 2008 Oct 13.


PRL-3 promotes epithelial mesenchymal transition by regulating cadherin directly.

Liu Y, Zhou J, Chen J, Gao W, Le Y, Ding Y, Li J.

Cancer Biol Ther. 2009 Jul;8(14):1352-9. Epub 2009 Jul 7.


Epigenetic regulation of EMT: the Snail story.

Lin Y, Dong C, Zhou BP.

Curr Pharm Des. 2014;20(11):1698-705. Review.


G9a orchestrates PCL3 and KDM7A to promote histone H3K27 methylation.

Pan MR, Hsu MC, Chen LT, Hung WC.

Sci Rep. 2015 Dec 21;5:18709. doi: 10.1038/srep18709.


Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer.

Dong C, Yuan T, Wu Y, Wang Y, Fan TW, Miriyala S, Lin Y, Yao J, Shi J, Kang T, Lorkiewicz P, St Clair D, Hung MC, Evers BM, Zhou BP.

Cancer Cell. 2013 Mar 18;23(3):316-31. doi: 10.1016/j.ccr.2013.01.022. Epub 2013 Feb 28.


Inhibition of epithelial to mesenchymal transition by E-cadherin up-regulation via repression of slug transcription and inhibition of E-cadherin degradation: dual role of scaffold/matrix attachment region-binding protein 1 (SMAR1) in breast cancer cells.

Adhikary A, Chakraborty S, Mazumdar M, Ghosh S, Mukherjee S, Manna A, Mohanty S, Nakka KK, Joshi S, De A, Chattopadhyay S, Sa G, Das T.

J Biol Chem. 2014 Sep 12;289(37):25431-44. doi: 10.1074/jbc.M113.527267. Epub 2014 Aug 1.


Histone lysine methyltransferase G9a is a novel epigenetic target for the treatment of hepatocellular carcinoma.

Yokoyama M, Chiba T, Zen Y, Oshima M, Kusakabe Y, Noguchi Y, Yuki K, Koide S, Tara S, Saraya A, Aoyama K, Mimura N, Miyagi S, Inoue M, Wakamatsu T, Saito T, Ogasawara S, Suzuki E, Ooka Y, Tawada A, Otsuka M, Miyazaki M, Yokosuka O, Iwama A.

Oncotarget. 2017 Mar 28;8(13):21315-21326. doi: 10.18632/oncotarget.15528.


Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer.

Aghdassi A, Sendler M, Guenther A, Mayerle J, Behn CO, Heidecke CD, Friess H, Büchler M, Evert M, Lerch MM, Weiss FU.

Gut. 2012 Mar;61(3):439-48. doi: 10.1136/gutjnl-2011-300060. Epub 2011 Dec 5.


E-cadherin regulates metastasis of pancreatic cancer in vivo and is suppressed by a SNAIL/HDAC1/HDAC2 repressor complex.

von Burstin J, Eser S, Paul MC, Seidler B, Brandl M, Messer M, von Werder A, Schmidt A, Mages J, Pagel P, Schnieke A, Schmid RM, Schneider G, Saur D.

Gastroenterology. 2009 Jul;137(1):361-71, 371.e1-5. doi: 10.1053/j.gastro.2009.04.004. Epub 2009 Apr 9.


Depletion of G9a gene induces cell apoptosis in human gastric carcinoma.

Lin X, Huang Y, Zou Y, Chen X, Ma X.

Oncol Rep. 2016 May;35(5):3041-9. doi: 10.3892/or.2016.4692. Epub 2016 Mar 17.


H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM.

Chen MW, Hua KT, Kao HJ, Chi CC, Wei LH, Johansson G, Shiah SG, Chen PS, Jeng YM, Cheng TY, Lai TC, Chang JS, Jan YH, Chien MH, Yang CJ, Huang MS, Hsiao M, Kuo ML.

Cancer Res. 2010 Oct 15;70(20):7830-40. doi: 10.1158/0008-5472.CAN-10-0833. Epub 2010 Oct 12.


Histone deacetylase inhibitor entinostat reverses epithelial to mesenchymal transition of breast cancer cells by reversing the repression of E-cadherin.

Shah P, Gau Y, Sabnis G.

Breast Cancer Res Treat. 2014 Jan;143(1):99-111. doi: 10.1007/s10549-013-2784-7. Epub 2013 Dec 5.


Distinct roles for histone methyltransferases G9a and GLP in cancer germ-line antigen gene regulation in human cancer cells and murine embryonic stem cells.

Link PA, Gangisetty O, James SR, Woloszynska-Read A, Tachibana M, Shinkai Y, Karpf AR.

Mol Cancer Res. 2009 Jun;7(6):851-62. doi: 10.1158/1541-7786.MCR-08-0497. Epub 2009 Jun 16.


G9A promotes tumor cell growth and invasion by silencing CASP1 in non-small-cell lung cancer cells.

Huang T, Zhang P, Li W, Zhao T, Zhang Z, Chen S, Yang Y, Feng Y, Li F, Shirley Liu X, Zhang L, Jiang G, Zhang F.

Cell Death Dis. 2017 Apr 6;8(4):e2726. doi: 10.1038/cddis.2017.65.


ERbeta1 represses basal breast cancer epithelial to mesenchymal transition by destabilizing EGFR.

Thomas C, Rajapaksa G, Nikolos F, Hao R, Katchy A, McCollum CW, Bondesson M, Quinlan P, Thompson A, Krishnamurthy S, Esteva FJ, Gustafsson JÅ.

Breast Cancer Res. 2012 Nov 16;14(6):R148. doi: 10.1186/bcr3358.

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