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Items: 1 to 20 of 113


Neural stem cell-mediated CE/CPT-11 enzyme/prodrug therapy in transgenic mouse model of intracerebellar medulloblastoma.

Gutova M, Shackleford GM, Khankaldyyan V, Herrmann KA, Shi XH, Mittelholtz K, Abramyants Y, Blanchard MS, Kim SU, Annala AJ, Najbauer J, Synold TW, D'Apuzzo M, Barish ME, Moats RA, Aboody KS.

Gene Ther. 2013 Feb;20(2):143-50. doi: 10.1038/gt.2012.12. Epub 2012 Mar 8.


Therapeutic targeting of subdural medulloblastomas using human neural stem cells expressing carboxylesterase.

Lim SH, Choi SA, Lee JY, Wang KC, Phi JH, Lee DH, Song SH, Song JH, Jin X, Kim H, Lee HJ, Lim I, Kim SU, Kim SK.

Cancer Gene Ther. 2011 Nov;18(11):817-24. doi: 10.1038/cgt.2011.52. Epub 2011 Aug 26.


Neural stem cell-mediated delivery of irinotecan-activating carboxylesterases to glioma: implications for clinical use.

Metz MZ, Gutova M, Lacey SF, Abramyants Y, Vo T, Gilchrist M, Tirughana R, Ghoda LY, Barish ME, Brown CE, Najbauer J, Potter PM, Portnow J, Synold TW, Aboody KS.

Stem Cells Transl Med. 2013 Dec;2(12):983-92. doi: 10.5966/sctm.2012-0177. Epub 2013 Oct 28.


Human neural stem cell tropism to metastatic breast cancer.

Zhao D, Najbauer J, Annala AJ, Garcia E, Metz MZ, Gutova M, Polewski MD, Gilchrist M, Glackin CA, Kim SU, Aboody KS.

Stem Cells. 2012 Feb;30(2):314-25. doi: 10.1002/stem.784.


Human neural stem cells target experimental intracranial medulloblastoma and deliver a therapeutic gene leading to tumor regression.

Kim SK, Kim SU, Park IH, Bang JH, Aboody KS, Wang KC, Cho BK, Kim M, Menon LG, Black PM, Carroll RS.

Clin Cancer Res. 2006 Sep 15;12(18):5550-6.


Tumor-targeted enzyme/prodrug therapy mediates long-term disease-free survival of mice bearing disseminated neuroblastoma.

Danks MK, Yoon KJ, Bush RA, Remack JS, Wierdl M, Tsurkan L, Kim SU, Garcia E, Metz MZ, Najbauer J, Potter PM, Aboody KS.

Cancer Res. 2007 Jan 1;67(1):22-5.


Therapeutic targeting of melanoma cells using neural stem cells expressing carboxylesterase, a CPT-11 activating enzyme.

Gutova M, Najbauer J, Chen MY, Potter PM, Kim SU, Aboody KS.

Curr Stem Cell Res Ther. 2010 Sep;5(3):273-6.


In vivo human carboxylesterase cDNA gene transfer to activate the prodrug CPT-11 for local treatment of solid tumors.

Kojima A, Hackett NR, Ohwada A, Crystal RG.

J Clin Invest. 1998 Apr 15;101(8):1789-96.


Double suicide gene therapy using human neural stem cells against glioblastoma: double safety measures.

Lee JY, Lee DH, Kim HA, Choi SA, Lee HJ, Park CK, Phi JH, Wang KC, Kim SU, Kim SK.

J Neurooncol. 2014 Jan;116(1):49-57. doi: 10.1007/s11060-013-1264-6. Epub 2013 Oct 11.


An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11.

Wierdl M, Tsurkan L, Hyatt JL, Edwards CC, Hatfield MJ, Morton CL, Houghton PJ, Danks MK, Redinbo MR, Potter PM.

Cancer Gene Ther. 2008 Mar;15(3):183-92. doi: 10.1038/sj.cgt.7701112. Epub 2008 Jan 11.


Genetically-engineered human neural stem cells with rabbit carboxyl esterase can target CNS lymphoma.

Kang W, Jin J, Yang H, Seol HJ, Kim KH, Lee JI, Kim SU, Joo KM, Nam DH.

Anticancer Res. 2013 Dec;33(12):5335-42.


Neural stem cell-mediated enzyme/prodrug therapy for glioma: preclinical studies.

Aboody KS, Najbauer J, Metz MZ, D'Apuzzo M, Gutova M, Annala AJ, Synold TW, Couture LA, Blanchard S, Moats RA, Garcia E, Aramburo S, Valenzuela VV, Frank RT, Barish ME, Brown CE, Kim SU, Badie B, Portnow J.

Sci Transl Med. 2013 May 8;5(184):184ra59. doi: 10.1126/scitranslmed.3005365.


Gene-directed enzyme prodrug therapy for osteosarcoma: sensitization to CPT-11 in vitro and in vivo by adenoviral delivery of a gene encoding secreted carboxylesterase-2.

Oosterhoff D, Witlox MA, van Beusechem VW, Haisma HJ, Schaap GR, Bras J, Kruyt FA, Molenaar B, Boven E, Wuisman PI, Pinedo HM, Gerritsen WR.

Mol Cancer Ther. 2003 Aug;2(8):765-71.


Human Neural Stem Cells Overexpressing a Carboxylesterase Inhibit Bladder Tumor Growth.

Choi SS, Chi BH, Chang IH, Kim KD, Lee SR, Kim SU, Lee HJ.

Mol Cancer Ther. 2016 Jun;15(6):1201-7. doi: 10.1158/1535-7163.MCT-15-0636. Epub 2016 Mar 23.


Synergistic effects of genetically engineered stem cells expressing cytosine deaminase and interferon-β via their tumor tropism to selectively target human hepatocarcinoma cells.

Yi BR, Hwang KA, Kang NH, Kim SU, Jeung EB, Kim HC, Choi KC.

Cancer Gene Ther. 2012 Sep;19(9):644-51. doi: 10.1038/cgt.2012.45. Epub 2012 Jul 13.


Bystander effect in suicide gene therapy using immortalized neural stem cells transduced with herpes simplex virus thymidine kinase gene on medulloblastoma regression.

Pu K, Li SY, Gao Y, Ma L, Ma W, Liu Y.

Brain Res. 2011 Jan 19;1369:245-52. doi: 10.1016/j.brainres.2010.10.107. Epub 2010 Nov 10.


A prodrug strategy using ONYX-015-based replicating adenoviruses to deliver rabbit carboxylesterase to tumor cells for conversion of CPT-11 to SN-38.

Stubdal H, Perin N, Lemmon M, Holman P, Bauzon M, Potter PM, Danks MK, Fattaey A, Dubensky T, Johnson L.

Cancer Res. 2003 Oct 15;63(20):6900-8.

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