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Items: 1 to 20 of 266

1.

A dissociated glucocorticoid receptor modulator reduces airway hyperresponsiveness and inflammation in a mouse model of asthma.

Reber LL, Daubeuf F, Plantinga M, De Cauwer L, Gerlo S, Waelput W, Van Calenbergh S, Tavernier J, Haegeman G, Lambrecht BN, Frossard N, De Bosscher K.

J Immunol. 2012 Apr 1;188(7):3478-87. doi: 10.4049/jimmunol.1004227. Epub 2012 Mar 5.

2.

Selective modulation of the glucocorticoid receptor can distinguish between transrepression of NF-κB and AP-1.

De Bosscher K, Beck IM, Dejager L, Bougarne N, Gaigneaux A, Chateauvieux S, Ratman D, Bracke M, Tavernier J, Vanden Berghe W, Libert C, Diederich M, Haegeman G.

Cell Mol Life Sci. 2014 Jan;71(1):143-63. doi: 10.1007/s00018-013-1367-4. Epub 2013 Jun 20.

3.

Geniposide inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma.

Deng Y, Guan M, Xie X, Yang X, Xiang H, Li H, Zou L, Wei J, Wang D, Deng X.

Int Immunopharmacol. 2013 Nov;17(3):561-7. doi: 10.1016/j.intimp.2013.06.028. Epub 2013 Jul 13.

PMID:
23859870
4.

Ursolic acid, a potential PPARγ agonist, suppresses ovalbumin-induced airway inflammation and Penh by down-regulating IL-5, IL-13, and IL-17 in a mouse model of allergic asthma.

Kim SH, Hong JH, Lee YC.

Eur J Pharmacol. 2013 Feb 15;701(1-3):131-43. doi: 10.1016/j.ejphar.2012.11.033. Epub 2012 Nov 28.

PMID:
23201068
5.

Compound A, a dissociated glucocorticoid receptor modulator, inhibits T-bet (Th1) and induces GATA-3 (Th2) activity in immune cells.

Liberman AC, Antunica-Noguerol M, Ferraz-de-Paula V, Palermo-Neto J, Castro CN, Druker J, Holsboer F, Perone MJ, Gerlo S, De Bosscher K, Haegeman G, Arzt E.

PLoS One. 2012;7(4):e35155. doi: 10.1371/journal.pone.0035155. Epub 2012 Apr 9. Erratum in: PLoS One. 2012;7(5): doi/10.1371/annotation/12a8fc89-5f47-4bad-8863-863d99a0e52d.

6.

Oleanolic acid suppresses ovalbumin-induced airway inflammation and Th2-mediated allergic asthma by modulating the transcription factors T-bet, GATA-3, RORγt and Foxp3 in asthmatic mice.

Kim SH, Hong JH, Lee YC.

Int Immunopharmacol. 2014 Feb;18(2):311-24. doi: 10.1016/j.intimp.2013.12.009. Epub 2013 Dec 27.

PMID:
24374304
7.

Anti-asthmatic effect of schizandrin on OVA-induced airway inflammation in a murine asthma model.

Lee MY, Seo CS, Lee NH, Ha H, Lee JA, Lee H, Lee KY, Shin HK.

Int Immunopharmacol. 2010 Nov;10(11):1374-9. doi: 10.1016/j.intimp.2010.07.014. Epub 2010 Aug 20.

PMID:
20727999
8.

Effects of (±)-praeruptorin A on airway inflammation, airway hyperresponsiveness and NF-κB signaling pathway in a mouse model of allergic airway disease.

Xiong Y, Wang J, Wu F, Li J, Zhou L, Kong L.

Eur J Pharmacol. 2012 May 15;683(1-3):316-24. doi: 10.1016/j.ejphar.2012.03.004. Epub 2012 Mar 15.

PMID:
22449378
9.

Differential mechanism of NF-kappaB inhibition by two glucocorticoid receptor modulators in rheumatoid arthritis synovial fibroblasts.

Gossye V, Elewaut D, Bougarne N, Bracke D, Van Calenbergh S, Haegeman G, De Bosscher K.

Arthritis Rheum. 2009 Nov;60(11):3241-50. doi: 10.1002/art.24963.

10.

A fully dissociated compound of plant origin for inflammatory gene repression.

De Bosscher K, Vanden Berghe W, Beck IM, Van Molle W, Hennuyer N, Hapgood J, Libert C, Staels B, Louw A, Haegeman G.

Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15827-32. Epub 2005 Oct 21.

11.

Effects of furosemide on allergic asthmatic responses in mice.

Wang S, Xiang YY, Ellis R, Wattie J, Feng M, Inman MD, Lu WY.

Clin Exp Allergy. 2011 Oct;41(10):1456-67. doi: 10.1111/j.1365-2222.2011.03811.x. Epub 2011 Jul 5.

PMID:
21729180
12.

A synthetic compound, 4-acetyl-3-methyl-6-(3,4,5-trimethoxyphenyl)pyrano[3,4-c]pyran-1,8-dione, ameliorates ovalbumin-induced asthma.

Chung HS, Kim Y, Oh SJ, Kim H, Choi SI, Zhang Y, Jeong JH, Bae H.

Bioorg Med Chem. 2013 Nov 1;21(21):6359-65. doi: 10.1016/j.bmc.2013.08.045. Epub 2013 Sep 3.

PMID:
24054491
13.

Histamine H4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokines.

Cowden JM, Riley JP, Ma JY, Thurmond RL, Dunford PJ.

Respir Res. 2010 Jun 24;11:86. doi: 10.1186/1465-9921-11-86.

14.

DA-9201 shows anti-asthmatic effects by suppressing NF-kappaB expression in an ovalbumin-induced mouse model of asthma.

Lee SH, Seo MJ, Choi SM, Sohn YS, Kang KK, Ahn BO, Kwon JW, Yoo M.

Arch Pharm Res. 2005 Dec;28(12):1350-7.

PMID:
16392668
15.

Anti-inflammatory and anti-asthmatic effects of resveratrol, a polyphenolic stilbene, in a mouse model of allergic asthma.

Lee M, Kim S, Kwon OK, Oh SR, Lee HK, Ahn K.

Int Immunopharmacol. 2009 Apr;9(4):418-24. doi: 10.1016/j.intimp.2009.01.005. Epub 2009 Feb 8.

PMID:
19185061
16.

CTLA4-IgG reverses asthma manifestations in a mild but not in a more "severe" ongoing murine model.

Deurloo DT, van Esch BC, Hofstra CL, Nijkamp FP, van Oosterhout AJ.

Am J Respir Cell Mol Biol. 2001 Dec;25(6):751-60.

PMID:
11726402
17.

Therapeutic and adverse effects of a non-steroidal glucocorticoid receptor ligand in a mouse model of multiple sclerosis.

Wüst S, Tischner D, John M, Tuckermann JP, Menzfeld C, Hanisch UK, van den Brandt J, Lühder F, Reichardt HM.

PLoS One. 2009 Dec 7;4(12):e8202. doi: 10.1371/journal.pone.0008202.

18.

Impact of psychosocial stress on airway inflammation and its mechanism in a murine model of allergic asthma.

Li B, Duan XH, Wu JF, Liu BJ, Luo QL, Jin HL, DU YJ, Zhang HY, Cao YX, Dong JC.

Chin Med J (Engl). 2013 Jan;126(2):325-34.

PMID:
23324285
19.

Mepacrine alleviates airway hyperresponsiveness and airway inflammation in a mouse model of asthma.

Ram A, Mabalirajan U, Singh SK, Singh VP, Ghosh B.

Int Immunopharmacol. 2008 Jun;8(6):893-9. doi: 10.1016/j.intimp.2008.02.005. Epub 2008 Mar 14.

PMID:
18442795

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