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Items: 1 to 20 of 103

1.

Structural analysis of the C-terminal region (modules 18-20) of complement regulator factor H (FH).

Morgan HP, Mertens HD, Guariento M, Schmidt CQ, Soares DC, Svergun DI, Herbert AP, Barlow PN, Hannan JP.

PLoS One. 2012;7(2):e32187. doi: 10.1371/journal.pone.0032187. Epub 2012 Feb 28.

2.

Structural and functional characterization of the product of disease-related factor H gene conversion.

Herbert AP, Kavanagh D, Johansson C, Morgan HP, Blaum BS, Hannan JP, Barlow PN, Uhrín D.

Biochemistry. 2012 Mar 6;51(9):1874-84. doi: 10.1021/bi201689j. Epub 2012 Feb 22.

PMID:
22320225
3.

The central portion of factor H (modules 10-15) is compact and contains a structurally deviant CCP module.

Schmidt CQ, Herbert AP, Mertens HD, Guariento M, Soares DC, Uhrin D, Rowe AJ, Svergun DI, Barlow PN.

J Mol Biol. 2010 Jan 8;395(1):105-22. doi: 10.1016/j.jmb.2009.10.010. Epub 2009 Oct 14.

4.

Crystallographic determination of the disease-associated T1184R variant of complement regulator factor H.

Morgan HP, Jiang J, Herbert AP, Kavanagh D, Uhrin D, Barlow PN, Hannan JP.

Acta Crystallogr D Biol Crystallogr. 2011 Jul;67(Pt 7):593-600. doi: 10.1107/S0907444911015423. Epub 2011 Jun 11.

PMID:
21697597
5.

Solution structure of CCP modules 10-12 illuminates functional architecture of the complement regulator, factor H.

Makou E, Mertens HD, Maciejewski M, Soares DC, Matis I, Schmidt CQ, Herbert AP, Svergun DI, Barlow PN.

J Mol Biol. 2012 Dec 14;424(5):295-312. doi: 10.1016/j.jmb.2012.09.013. Epub 2012 Sep 25.

6.

Structure of complement fragment C3b-factor H and implications for host protection by complement regulators.

Wu J, Wu YQ, Ricklin D, Janssen BJ, Lambris JD, Gros P.

Nat Immunol. 2009 Jul;10(7):728-33. doi: 10.1038/ni.1755. Epub 2009 Jun 7.

7.

Disease-associated N-terminal complement factor H mutations perturb cofactor and decay-accelerating activities.

Pechtl IC, Kavanagh D, McIntosh N, Harris CL, Barlow PN.

J Biol Chem. 2011 Apr 1;286(13):11082-90. doi: 10.1074/jbc.M110.211839. Epub 2011 Jan 26.

8.

A new map of glycosaminoglycan and C3b binding sites on factor H.

Schmidt CQ, Herbert AP, Kavanagh D, Gandy C, Fenton CJ, Blaum BS, Lyon M, Uhrín D, Barlow PN.

J Immunol. 2008 Aug 15;181(4):2610-9.

9.

Structural basis for engagement by complement factor H of C3b on a self surface.

Morgan HP, Schmidt CQ, Guariento M, Blaum BS, Gillespie D, Herbert AP, Kavanagh D, Mertens HD, Svergun DI, Johansson CM, Uhrín D, Barlow PN, Hannan JP.

Nat Struct Mol Biol. 2011 Apr;18(4):463-70. doi: 10.1038/nsmb.2018. Epub 2011 Feb 13.

10.

Use of time-resolved FRET to validate crystal structure of complement regulatory complex between C3b and factor H (N terminus).

Pechtl IC, Neely RK, Dryden DT, Jones AC, Barlow PN.

Protein Sci. 2011 Dec;20(12):2102-12. doi: 10.1002/pro.738.

11.

Insights into the Effects of Complement Factor H on the Assembly and Decay of the Alternative Pathway C3 Proconvertase and C3 Convertase.

Bettoni S, Bresin E, Remuzzi G, Noris M, Donadelli R.

J Biol Chem. 2016 Apr 8;291(15):8214-30. doi: 10.1074/jbc.M115.693119. Epub 2016 Feb 22. Retraction in: J Biol Chem. 2017 Apr 14;292(15):6094.

12.

Translational mini-review series on complement factor H: structural and functional correlations for factor H.

Schmidt CQ, Herbert AP, Hocking HG, Uhrín D, Barlow PN.

Clin Exp Immunol. 2008 Jan;151(1):14-24. Review.

13.

Disturbed sialic acid recognition on endothelial cells and platelets in complement attack causes atypical hemolytic uremic syndrome.

Hyvärinen S, Meri S, Jokiranta TS.

Blood. 2016 Jun 2;127(22):2701-10. doi: 10.1182/blood-2015-11-680009. Epub 2016 Mar 22.

14.

Complement Evasion Mediated by Enhancement of Captured Factor H: Implications for Protection of Self-Surfaces from Complement.

Herbert AP, Makou E, Chen ZA, Kerr H, Richards A, Rappsilber J, Barlow PN.

J Immunol. 2015 Nov 15;195(10):4986-98. doi: 10.4049/jimmunol.1501388. Epub 2015 Oct 12.

15.

Energetic evaluation of binding modes in the C3d and Factor H (CCP 19-20) complex.

E S Harrison R, Gorham RD Jr, Morikis D.

Protein Sci. 2015 May;24(5):789-802. doi: 10.1002/pro.2650. Epub 2015 Mar 11.

16.

Disease-linked mutations in factor H reveal pivotal role of cofactor activity in self-surface-selective regulation of complement activation.

Kerr H, Wong E, Makou E, Yang Y, Marchbank K, Kavanagh D, Richards A, Herbert AP, Barlow PN.

J Biol Chem. 2017 Aug 11;292(32):13345-13360. doi: 10.1074/jbc.M117.795088. Epub 2017 Jun 21.

17.

Both domain 19 and domain 20 of factor H are involved in binding to complement C3b and C3d.

Bhattacharjee A, Lehtinen MJ, Kajander T, Goldman A, Jokiranta TS.

Mol Immunol. 2010 May;47(9):1686-91. doi: 10.1016/j.molimm.2010.03.007. Epub 2010 Apr 7.

PMID:
20378178
18.

Mutations in Complement Factor H Impair Alternative Pathway Regulation on Mouse Glomerular Endothelial Cells in Vitro.

Loeven MA, Rops AL, Lehtinen MJ, van Kuppevelt TH, Daha MR, Smith RJ, Bakker M, Berden JH, Rabelink TJ, Jokiranta TS, van der Vlag J.

J Biol Chem. 2016 Mar 4;291(10):4974-81. doi: 10.1074/jbc.M115.702506. Epub 2016 Jan 4.

20.

Structure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndrome.

Jokiranta TS, Jaakola VP, Lehtinen MJ, Pärepalo M, Meri S, Goldman A.

EMBO J. 2006 Apr 19;25(8):1784-94. Epub 2006 Apr 6.

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