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CLIC4 is a tumor suppressor for cutaneous squamous cell cancer.

Suh KS, Malik M, Shukla A, Ryscavage A, Wright L, Jividen K, Crutchley JM, Dumont RA, Fernandez-Salas E, Webster JD, Simpson RM, Yuspa SH.

Carcinogenesis. 2012 May;33(5):986-95. doi: 10.1093/carcin/bgs115. Epub 2012 Mar 1.


TGF-beta signalling is regulated by Schnurri-2-dependent nuclear translocation of CLIC4 and consequent stabilization of phospho-Smad2 and 3.

Shukla A, Malik M, Cataisson C, Ho Y, Friesen T, Suh KS, Yuspa SH.

Nat Cell Biol. 2009 Jun;11(6):777-84. doi: 10.1038/ncb1885. Epub 2009 May 17.


Elevating CLIC4 in Multiple Cell Types Reveals a TGF- Dependent Induction of a Dominant Negative Smad7 Splice Variant.

Shukla A, Yang Y, Madanikia S, Ho Y, Li M, Sanchez V, Cataisson C, Huang J, Yuspa SH.

PLoS One. 2016 Aug 18;11(8):e0161410. doi: 10.1371/journal.pone.0161410. eCollection 2016. Erratum in: PLoS One. 2016 Dec 12;11(12 ):e0168629.


CLIC4, skin homeostasis and cutaneous cancer: surprising connections.

Suh KS, Malik M, Shukla A, Yuspa SH.

Mol Carcinog. 2007 Aug;46(8):599-604. Review.


S-nitrosylation regulates nuclear translocation of chloride intracellular channel protein CLIC4.

Malik M, Shukla A, Amin P, Niedelman W, Lee J, Jividen K, Phang JM, Ding J, Suh KS, Curmi PM, Yuspa SH.

J Biol Chem. 2010 Jul 30;285(31):23818-28. doi: 10.1074/jbc.M109.091611. Epub 2010 May 26.


CLIC4 mediates and is required for Ca2+-induced keratinocyte differentiation.

Suh KS, Mutoh M, Mutoh T, Li L, Ryscavage A, Crutchley JM, Dumont RA, Cheng C, Yuspa SH.

J Cell Sci. 2007 Aug 1;120(Pt 15):2631-40. Epub 2007 Jul 17.


The organellular chloride channel protein CLIC4/mtCLIC translocates to the nucleus in response to cellular stress and accelerates apoptosis.

Suh KS, Mutoh M, Nagashima K, Fernandez-Salas E, Edwards LE, Hayes DD, Crutchley JM, Marin KG, Dumont RA, Levy JM, Cheng C, Garfield S, Yuspa SH.

J Biol Chem. 2004 Feb 6;279(6):4632-41. Epub 2003 Nov 10.


CLIC4, an intracellular chloride channel protein, is a novel molecular target for cancer therapy.

Suh KS, Mutoh M, Gerdes M, Yuspa SH.

J Investig Dermatol Symp Proc. 2005 Nov;10(2):105-9.


Reciprocal modifications of CLIC4 in tumor epithelium and stroma mark malignant progression of multiple human cancers.

Suh KS, Crutchley JM, Koochek A, Ryscavage A, Bhat K, Tanaka T, Oshima A, Fitzgerald P, Yuspa SH.

Clin Cancer Res. 2007 Jan 1;13(1):121-31.


Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear translocation regulates macrophage deactivation.

Malik M, Jividen K, Padmakumar VC, Cataisson C, Li L, Lee J, Howard OM, Yuspa SH.

Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6130-5. doi: 10.1073/pnas.1201351109. Epub 2012 Apr 2.


CLIC4 regulates TGF-β-dependent myofibroblast differentiation to produce a cancer stroma.

Shukla A, Edwards R, Yang Y, Hahn A, Folkers K, Ding J, Padmakumar VC, Cataisson C, Suh KS, Yuspa SH.

Oncogene. 2014 Feb 13;33(7):842-50. doi: 10.1038/onc.2013.18. Epub 2013 Feb 18.


Antisense suppression of the chloride intracellular channel family induces apoptosis, enhances tumor necrosis factor {alpha}-induced apoptosis, and inhibits tumor growth.

Suh KS, Mutoh M, Gerdes M, Crutchley JM, Mutoh T, Edwards LE, Dumont RA, Sodha P, Cheng C, Glick A, Yuspa SH.

Cancer Res. 2005 Jan 15;65(2):562-71.


Spontaneous skin erosions and reduced skin and corneal wound healing characterize CLIC4(NULL) mice.

Padmakumar VC, Speer K, Pal-Ghosh S, Masiuk KE, Ryscavage A, Dengler SL, Hwang S, Edwards JC, Coppola V, Tessarollo L, Stepp MA, Yuspa SH.

Am J Pathol. 2012 Jul;181(1):74-84. doi: 10.1016/j.ajpath.2012.03.025. Epub 2012 May 18.


Detection of differential fetal and adult expression of chloride intracellular channel 4 (CLIC4) protein by analysis of a green fluorescent protein knock-in mouse line.

Padmakumar V, Masiuk KE, Luger D, Lee C, Coppola V, Tessarollo L, Hoover SB, Karavanova I, Buonanno A, Simpson RM, Yuspa SH.

BMC Dev Biol. 2014 May 28;14:24. doi: 10.1186/1471-213X-14-24.


Role of CLIC4 in the host innate responses to bacterial lipopolysaccharide.

He G, Ma Y, Chou SY, Li H, Yang C, Chuang JZ, Sung CH, Ding A.

Eur J Immunol. 2011 May;41(5):1221-30. doi: 10.1002/eji.201041266. Epub 2011 Apr 20. Erratum in: Eur J Immunol. 2011 Jun;41(6):1809.


Smad7 but not Smad6 cooperates with oncogenic ras to cause malignant conversion in a mouse model for squamous cell carcinoma.

Liu X, Lee J, Cooley M, Bhogte E, Hartley S, Glick A.

Cancer Res. 2003 Nov 15;63(22):7760-8.


Functional roles of Akt signaling in mouse skin tumorigenesis.

Segrelles C, Ruiz S, Perez P, Murga C, Santos M, Budunova IV, Martínez J, Larcher F, Slaga TJ, Gutkind JS, Jorcano JL, Paramio JM.

Oncogene. 2002 Jan 3;21(1):53-64.


Inducible expression of transforming growth factor beta1 in papillomas causes rapid metastasis.

Weeks BH, He W, Olson KL, Wang XJ.

Cancer Res. 2001 Oct 15;61(20):7435-43.

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