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PPARδ prevents radiation-induced proinflammatory responses in microglia via transrepression of NF-κB and inhibition of the PKCα/MEK1/2/ERK1/2/AP-1 pathway.

Schnegg CI, Kooshki M, Hsu FC, Sui G, Robbins ME.

Free Radic Biol Med. 2012 May 1;52(9):1734-43. doi: 10.1016/j.freeradbiomed.2012.02.032. Epub 2012 Mar 3.


PPARalpha ligands inhibit radiation-induced microglial inflammatory responses by negatively regulating NF-kappaB and AP-1 pathways.

Ramanan S, Kooshki M, Zhao W, Hsu FC, Robbins ME.

Free Radic Biol Med. 2008 Dec 15;45(12):1695-704. doi: 10.1016/j.freeradbiomed.2008.09.002. Epub 2008 Sep 17.


Kukoamine A Prevents Radiation-Induced Neuroinflammation and Preserves Hippocampal Neurogenesis in Rats by Inhibiting Activation of NF-κB and AP-1.

Zhang Y, Gao L, Cheng Z, Cai J, Niu Y, Meng W, Zhao Q.

Neurotox Res. 2017 Feb;31(2):259-268. doi: 10.1007/s12640-016-9679-4. Epub 2016 Nov 4.


Peroxisome proliferator-activated receptor {delta} regulates inflammation via NF-{kappa}B signaling in polymicrobial sepsis.

Zingarelli B, Piraino G, Hake PW, O'Connor M, Denenberg A, Fan H, Cook JA.

Am J Pathol. 2010 Oct;177(4):1834-47. doi: 10.2353/ajpath.2010.091010. Epub 2010 Aug 13.


The PPARδ agonist GW0742 inhibits neuroinflammation, but does not restore neurogenesis or prevent early delayed hippocampal-dependent cognitive impairment after whole-brain irradiation.

Schnegg CI, Greene-Schloesser D, Kooshki M, Payne VS, Hsu FC, Robbins ME.

Free Radic Biol Med. 2013 Aug;61:1-9. doi: 10.1016/j.freeradbiomed.2013.03.002. Epub 2013 Mar 14.


Activation of peroxisome proliferator-activated receptor-{delta} by GW501516 prevents fatty acid-induced nuclear factor-{kappa}B activation and insulin resistance in skeletal muscle cells.

Coll T, Alvarez-Guardia D, Barroso E, Gómez-Foix AM, Palomer X, Laguna JC, Vázquez-Carrera M.

Endocrinology. 2010 Apr;151(4):1560-9. doi: 10.1210/en.2009-1211. Epub 2010 Feb 25.


Luteolin suppresses inflammation-associated gene expression by blocking NF-kappaB and AP-1 activation pathway in mouse alveolar macrophages.

Chen CY, Peng WH, Tsai KD, Hsu SL.

Life Sci. 2007 Nov 30;81(23-24):1602-14. Epub 2007 Oct 5.


Resveratrol differentially modulates inflammatory responses of microglia and astrocytes.

Lu X, Ma L, Ruan L, Kong Y, Mou H, Zhang Z, Wang Z, Wang JM, Le Y.

J Neuroinflammation. 2010 Aug 17;7:46. doi: 10.1186/1742-2094-7-46.


Activation of peroxisome proliferator-activated receptor beta/delta inhibits lipopolysaccharide-induced cytokine production in adipocytes by lowering nuclear factor-kappaB activity via extracellular signal-related kinase 1/2.

Rodríguez-Calvo R, Serrano L, Coll T, Moullan N, Sánchez RM, Merlos M, Palomer X, Laguna JC, Michalik L, Wahli W, Vázquez-Carrera M.

Diabetes. 2008 Aug;57(8):2149-57. doi: 10.2337/db08-0176. Epub 2008 Apr 28.


Aspirin-triggered lipoxin A4 attenuates LPS-induced pro-inflammatory responses by inhibiting activation of NF-κB and MAPKs in BV-2 microglial cells.

Wang YP, Wu Y, Li LY, Zheng J, Liu RG, Zhou JP, Yuan SY, Shang Y, Yao SL.

J Neuroinflammation. 2011 Aug 10;8:95. doi: 10.1186/1742-2094-8-95.


Inhibitory effect of ent-Sauchinone on amyloidogenesis via inhibition of STAT3-mediated NF-κB activation in cultured astrocytes and microglial BV-2 cells.

Song SY, Jung YY, Hwang CJ, Lee HP, Sok CH, Kim JH, Lee SM, Seo HO, Hyun BK, Choi DY, Han SB, Ham YW, Hwang BY, Hong JT.

J Neuroinflammation. 2014 Jul 2;11:118. doi: 10.1186/1742-2094-11-118.


Neoechinulin A suppresses amyloid-β oligomer-induced microglia activation and thereby protects PC-12 cells from inflammation-mediated toxicity.

Dewapriya P, Li YX, Himaya SW, Pangestuti R, Kim SK.

Neurotoxicology. 2013 Mar;35:30-40. doi: 10.1016/j.neuro.2012.12.004. Epub 2012 Dec 21.


Radiation-induced c-Jun activation depends on MEK1-ERK1/2 signaling pathway in microglial cells.

Deng Z, Sui G, Rosa PM, Zhao W.

PLoS One. 2012;7(5):e36739. doi: 10.1371/journal.pone.0036739. Epub 2012 May 14.


Cilostazol is anti-inflammatory in BV2 microglial cells by inactivating nuclear factor-kappaB and inhibiting mitogen-activated protein kinases.

Jung WK, Lee DY, Park C, Choi YH, Choi I, Park SG, Seo SK, Lee SW, Yea SS, Ahn SC, Lee CM, Park WS, Ko JH, Choi IW.

Br J Pharmacol. 2010 Mar;159(6):1274-85. doi: 10.1111/j.1476-5381.2009.00615.x. Epub 2010 Jan 28.


Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-κB pathways.

Park J, Min JS, Kim B, Chae UB, Yun JW, Choi MS, Kong IK, Chang KT, Lee DS.

Neurosci Lett. 2015 Jan 1;584:191-6. doi: 10.1016/j.neulet.2014.10.016. Epub 2014 Oct 22.


Role of sestrin2 in the regulation of proinflammatory signaling in macrophages.

Yang JH, Kim KM, Kim MG, Seo KH, Han JY, Ka SO, Park BH, Shin SM, Ku SK, Cho IJ, Ki SH.

Free Radic Biol Med. 2015 Jan;78:156-67. doi: 10.1016/j.freeradbiomed.2014.11.002. Epub 2014 Nov 13.


Gomisin A inhibits lipopolysaccharide-induced inflammatory responses in N9 microglia via blocking the NF-κB/MAPKs pathway.

Wang X, Hu D, Zhang L, Lian G, Zhao S, Wang C, Yin J, Wu C, Yang J.

Food Chem Toxicol. 2014 Jan;63:119-27. doi: 10.1016/j.fct.2013.10.048. Epub 2013 Nov 7.


Telmisartan inhibits the proinflammatory effects of homocysteine on human endothelial cells through activation of the peroxisome proliferator-activated receptor-δ pathway.

Xu S, Song H, Huang M, Wang K, Xu C, Xie L.

Int J Mol Med. 2014 Sep;34(3):828-34. doi: 10.3892/ijmm.2014.1834. Epub 2014 Jul 3.


Differential regulation of RANTES and IL-8 expression in lung adenocarcinoma cells.

Henriquet C, Gougat C, Combes A, Lazennec G, Mathieu M.

Lung Cancer. 2007 May;56(2):167-74. Epub 2007 Jan 17.

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