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HIV-2 viral protein X (Vpx) ubiquitination is dispensable for ubiquitin ligase interaction and effects on macrophage infection.

McCulley A, Ratner L.

Virology. 2012 May 25;427(1):67-75. doi: 10.1016/j.virol.2012.02.002. Epub 2012 Mar 3.


The human immunodeficiency virus type 2 Vpx protein usurps the CUL4A-DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infection.

Bergamaschi A, Ayinde D, David A, Le Rouzic E, Morel M, Collin G, Descamps D, Damond F, Brun-Vezinet F, Nisole S, Margottin-Goguet F, Pancino G, Transy C.

J Virol. 2009 May;83(10):4854-60. doi: 10.1128/JVI.00187-09. Epub 2009 Mar 4.


HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1.

Ahn J, Hao C, Yan J, DeLucia M, Mehrens J, Wang C, Gronenborn AM, Skowronski J.

J Biol Chem. 2012 Apr 6;287(15):12550-8. doi: 10.1074/jbc.M112.340711. Epub 2012 Feb 23.


A novel DCAF1-binding motif required for Vpx-mediated degradation of nuclear SAMHD1 and Vpr-induced G2 arrest.

Wei W, Guo H, Han X, Liu X, Zhou X, Zhang W, Yu XF.

Cell Microbiol. 2012 Nov;14(11):1745-56. doi: 10.1111/j.1462-5822.2012.01835.x. Epub 2012 Aug 9.


Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection.

Srivastava S, Swanson SK, Manel N, Florens L, Washburn MP, Skowronski J.

PLoS Pathog. 2008 May 9;4(5):e1000059. doi: 10.1371/journal.ppat.1000059.


HIV-2 and SIVmac accessory virulence factor Vpx down-regulates SAMHD1 enzyme catalysis prior to proteasome-dependent degradation.

DeLucia M, Mehrens J, Wu Y, Ahn J.

J Biol Chem. 2013 Jun 28;288(26):19116-26. doi: 10.1074/jbc.M113.469007. Epub 2013 May 15.


Characterization of simian immunodeficiency virus SIVSM/human immunodeficiency virus type 2 Vpx function in human myeloid cells.

Goujon C, Arfi V, Pertel T, Luban J, Lienard J, Rigal D, Darlix JL, Cimarelli A.

J Virol. 2008 Dec;82(24):12335-45. doi: 10.1128/JVI.01181-08. Epub 2008 Oct 1.


Degradation of SAMHD1 by Vpx Is Independent of Uncoating.

J√°uregui P, Logue EC, Schultz ML, Fung S, Landau NR.

J Virol. 2015 May;89(10):5701-13. doi: 10.1128/JVI.03575-14. Epub 2015 Mar 11.


Cullin4A and cullin4B are interchangeable for HIV Vpr and Vpx action through the CRL4 ubiquitin ligase complex.

Sharifi HJ, Furuya AK, Jellinger RM, Nekorchuk MD, de Noronha CM.

J Virol. 2014 Jun;88(12):6944-58. doi: 10.1128/JVI.00241-14. Epub 2014 Apr 9.


Intracellular transport and virion incorporation of vpx requires interaction with other virus type-specific components.

Kappes JC, Parkin JS, Conway JA, Kim J, Brouillette CG, Shaw GM, Hahn BH.

Virology. 1993 Mar;193(1):222-33.


Vpx is critical for SIVmne infection of pigtail macaques.

Belshan M, Kimata JT, Brown C, Cheng X, McCulley A, Larsen A, Thippeshappa R, Hodara V, Giavedoni L, Hirsch V, Ratner L.

Retrovirology. 2012 Apr 24;9:32. doi: 10.1186/1742-4690-9-32.


Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein.

Hrecka K, Hao C, Gierszewska M, Swanson SK, Kesik-Brodacka M, Srivastava S, Florens L, Washburn MP, Skowronski J.

Nature. 2011 Jun 29;474(7353):658-61. doi: 10.1038/nature10195.


Human immunodeficiency virus type 2 vpx protein augments viral infectivity.

Kappes JC, Conway JA, Lee SW, Shaw GM, Hahn BH.

Virology. 1991 Sep;184(1):197-209.


Functional region mapping of HIV-2 Vpx protein.

Fujita M, Otsuka M, Nomaguchi M, Adachi A.

Microbes Infect. 2008 Oct;10(12-13):1387-92. doi: 10.1016/j.micinf.2008.08.005. Epub 2008 Aug 14.


The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus.

Hofmann H, Logue EC, Bloch N, Daddacha W, Polsky SB, Schultz ML, Kim B, Landau NR.

J Virol. 2012 Dec;86(23):12552-60. doi: 10.1128/JVI.01657-12. Epub 2012 Sep 12.


Evidence for an activation domain at the amino terminus of simian immunodeficiency virus Vpx.

Gramberg T, Sunseri N, Landau NR.

J Virol. 2010 Feb;84(3):1387-96. doi: 10.1128/JVI.01437-09. Epub 2009 Nov 18.


Lentivirus Vpr and Vpx accessory proteins usurp the cullin4-DDB1 (DCAF1) E3 ubiquitin ligase.

Romani B, Cohen EA.

Curr Opin Virol. 2012 Dec;2(6):755-63. doi: 10.1016/j.coviro.2012.09.010. Epub 2012 Oct 10. Review.


Understanding the molecular manipulation of DCAF1 by the lentiviral accessory proteins Vpr and Vpx.

Cassiday PA, DePaula-Silva AB, Chumley J, Ward J, Barker E, Planelles V.

Virology. 2015 Feb;476:19-25. doi: 10.1016/j.virol.2014.11.024. Epub 2014 Dec 11.

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