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Items: 1 to 20 of 162

1.

Native intact mass determination of antibodies conjugated with monomethyl Auristatin E and F at interchain cysteine residues.

Valliere-Douglass JF, McFee WA, Salas-Solano O.

Anal Chem. 2012 Mar 20;84(6):2843-9. doi: 10.1021/ac203346c. Epub 2012 Mar 2.

PMID:
22384990
2.

Conformation and dynamics of interchain cysteine-linked antibody-drug conjugates as revealed by hydrogen/deuterium exchange mass spectrometry.

Pan LY, Salas-Solano O, Valliere-Douglass JF.

Anal Chem. 2014 Mar 4;86(5):2657-64. doi: 10.1021/ac404003q. Epub 2014 Feb 21.

PMID:
24512515
3.

A rapid on-line method for mass spectrometric confirmation of a cysteine-conjugated antibody-drug-conjugate structure using multidimensional chromatography.

Birdsall RE, Shion H, Kotch FW, Xu A, Porter TJ, Chen W.

MAbs. 2015;7(6):1036-44. doi: 10.1080/19420862.2015.1083665. Epub 2015 Aug 25.

4.

Characterization of cysteine-linked conjugation profiles of immunoglobulin G1 and immunoglobulin G2 antibody-drug conjugates.

Wiggins B, Liu-Shin L, Yamaguchi H, Ratnaswamy G.

J Pharm Sci. 2015 Apr;104(4):1362-72. doi: 10.1002/jps.24338. Epub 2015 Jan 28.

PMID:
25631158
5.

Auristatin antibody drug conjugate physical instability and the role of drug payload.

Adem YT, Schwarz KA, Duenas E, Patapoff TW, Galush WJ, Esue O.

Bioconjug Chem. 2014 Apr 16;25(4):656-64. doi: 10.1021/bc400439x. Epub 2014 Mar 13.

PMID:
24559399
6.

In vivo drug-linker stability of an anti-CD30 dipeptide-linked auristatin immunoconjugate.

Sanderson RJ, Hering MA, James SF, Sun MM, Doronina SO, Siadak AW, Senter PD, Wahl AF.

Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):843-52.

7.

Approaches to Interchain Cysteine-Linked ADC Characterization by Mass Spectrometry.

Valliere-Douglass JF, Hengel SM, Pan LY.

Mol Pharm. 2015 Jun 1;12(6):1774-83. doi: 10.1021/mp500614p. Epub 2014 Dec 17. Review.

PMID:
25474122
8.

Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats.

Boswell CA, Mundo EE, Zhang C, Bumbaca D, Valle NR, Kozak KR, Fourie A, Chuh J, Koppada N, Saad O, Gill H, Shen BQ, Rubinfeld B, Tibbitts J, Kaur S, Theil FP, Fielder PJ, Khawli LA, Lin K.

Bioconjug Chem. 2011 Oct 19;22(10):1994-2004. doi: 10.1021/bc200212a. Epub 2011 Oct 3.

PMID:
21913715
9.

A rapid approach for characterization of thiol-conjugated antibody-drug conjugates and calculation of drug-antibody ratio by liquid chromatography mass spectrometry.

Firth D, Bell L, Squires M, Estdale S, McKee C.

Anal Biochem. 2015 Sep 15;485:34-42. doi: 10.1016/j.ab.2015.06.001. Epub 2015 Jun 9.

PMID:
26070852
10.

Antibody-Drug Conjugates (ADCs) Derived from Interchain Cysteine Cross-Linking Demonstrate Improved Homogeneity and Other Pharmacological Properties over Conventional Heterogeneous ADCs.

Behrens CR, Ha EH, Chinn LL, Bowers S, Probst G, Fitch-Bruhns M, Monteon J, Valdiosera A, Bermudez A, Liao-Chan S, Wong T, Melnick J, Theunissen JW, Flory MR, Houser D, Venstrom K, Levashova Z, Sauer P, Migone TS, van der Horst EH, Halcomb RL, Jackson DY.

Mol Pharm. 2015 Nov 2;12(11):3986-98. doi: 10.1021/acs.molpharmaceut.5b00432. Epub 2015 Oct 2.

PMID:
26393951
11.

Characterization of intact antibody-drug conjugates from plasma/serum in vivo by affinity capture capillary liquid chromatography-mass spectrometry.

Xu K, Liu L, Saad OM, Baudys J, Williams L, Leipold D, Shen B, Raab H, Junutula JR, Kim A, Kaur S.

Anal Biochem. 2011 May 1;412(1):56-66. doi: 10.1016/j.ab.2011.01.004. Epub 2011 Jan 7.

PMID:
21216214
12.

Measurement of in vivo drug load distribution of cysteine-linked antibody-drug conjugates using microscale liquid chromatography mass spectrometry.

Hengel SM, Sanderson R, Valliere-Douglass J, Nicholas N, Leiske C, Alley SC.

Anal Chem. 2014 Apr 1;86(7):3420-5. doi: 10.1021/ac403860c. Epub 2014 Mar 14.

PMID:
24576206
13.

Investigation into temperature-induced aggregation of an antibody drug conjugate.

Beckley NS, Lazzareschi KP, Chih HW, Sharma VK, Flores HL.

Bioconjug Chem. 2013 Oct 16;24(10):1674-83. doi: 10.1021/bc400182x. Epub 2013 Sep 26.

PMID:
24070051
14.

Characterization and Higher-Order Structure Assessment of an Interchain Cysteine-Based ADC: Impact of Drug Loading and Distribution on the Mechanism of Aggregation.

Guo J, Kumar S, Chipley M, Marcq O, Gupta D, Jin Z, Tomar DS, Swabowski C, Smith J, Starkey JA, Singh SK.

Bioconjug Chem. 2016 Mar 16;27(3):604-15. doi: 10.1021/acs.bioconjchem.5b00603. Epub 2016 Feb 16.

PMID:
26829368
15.

Site-Specific Conjugation of Monomethyl Auristatin E to Anti-CD30 Antibodies Improves Their Pharmacokinetics and Therapeutic Index in Rodent Models.

Lhospice F, Brégeon D, Belmant C, Dennler P, Chiotellis A, Fischer E, Gauthier L, Boëdec A, Rispaud H, Savard-Chambard S, Represa A, Schneider N, Paturel C, Sapet M, Delcambre C, Ingoure S, Viaud N, Bonnafous C, Schibli R, Romagné F.

Mol Pharm. 2015 Jun 1;12(6):1863-71. doi: 10.1021/mp500666j. Epub 2015 Feb 9.

PMID:
25625323
16.

Identification and localization of unpaired cysteine residues in monoclonal antibodies by fluorescence labeling and mass spectrometry.

Chumsae C, Gaza-Bulseco G, Liu H.

Anal Chem. 2009 Aug 1;81(15):6449-57. doi: 10.1021/ac900815z.

PMID:
19572546
17.

Engineered antibody-drug conjugates with defined sites and stoichiometries of drug attachment.

McDonagh CF, Turcott E, Westendorf L, Webster JB, Alley SC, Kim K, Andreyka J, Stone I, Hamblett KJ, Francisco JA, Carter P.

Protein Eng Des Sel. 2006 Jul;19(7):299-307. Epub 2006 Apr 27.

PMID:
16644914
18.

Characterization of antibody drug conjugate positional isomers at cysteine residues by peptide mapping LC-MS analysis.

Janin-Bussat MC, Dillenbourg M, Corvaia N, Beck A, Klinguer-Hamour C.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Feb 15;981-982:9-13. doi: 10.1016/j.jchromb.2014.12.017. Epub 2014 Dec 24.

PMID:
25596378
19.

Antibody-conjugated drug assay for protease-cleavable antibody-drug conjugates.

Sanderson RJ, Nicholas ND, Baker Lee C, Hengel SM, Lyon RP, Benjamin DR, Alley SC.

Bioanalysis. 2016;8(1):55-63. doi: 10.4155/bio.15.230. Epub 2015 Dec 9.

PMID:
26647801
20.

Development of a native nanoelectrospray mass spectrometry method for determination of the drug-to-antibody ratio of antibody-drug conjugates.

Chen J, Yin S, Wu Y, Ouyang J.

Anal Chem. 2013 Feb 5;85(3):1699-704. doi: 10.1021/ac302959p. Epub 2013 Jan 18.

PMID:
23289544

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