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Molecular targets for 17α-ethynyl-5-androstene-3β,7β,17β-triol, an anti-inflammatory agent derived from the human metabolome.

Reading CL, Frincke JM, White SK.

PLoS One. 2012;7(2):e32147. doi: 10.1371/journal.pone.0032147. Epub 2012 Feb 24.


Amelioration of glucose intolerance by the synthetic androstene HE3286: link to inflammatory pathways.

Wang T, Villegas S, Huang Y, White SK, Ahlem C, Lu M, Olefsky JM, Reading C, Frincke JM, Alleva D, Flores-Riveros J.

J Pharmacol Exp Ther. 2010 Apr;333(1):70-80. doi: 10.1124/jpet.109.161182. Epub 2010 Jan 12.


Studies of the pharmacology of 17α-ethynyl-androst-5-ene-3β,7β,17β-triol, a synthetic anti-inflammatory androstene.

Ahlem CN, Kennedy MR, Page TM, Reading CL, White SK, McKenzie JJ, Cole PI, Stickney DR, Frincke JM.

Int J Clin Exp Med. 2011;4(2):119-35. Epub 2011 Apr 23.


An orally bioavailable synthetic analog of an active dehydroepiandrosterone metabolite reduces established disease in rodent models of rheumatoid arthritis.

Offner H, Firestein GS, Boyle DL, Pieters R, Frincke JM, Garsd A, White SK, Reading CL, Auci DL.

J Pharmacol Exp Ther. 2009 Jun;329(3):1100-9. doi: 10.1124/jpet.108.145086. Epub 2009 Mar 18.


HE3286, an orally bioavailable synthetic analogue of an active DHEA metabolite suppresses spontaneous autoimmune diabetes in the non-obese diabetic (NOD) mouse.

Kosiewicz MM, Auci DL, Fagone P, Mangano K, Caponnetto S, Tucker CF, Azeem N, White SK, Frincke JM, Reading CL, Nicoletti F.

Eur J Pharmacol. 2011 May 11;658(2-3):257-62. doi: 10.1016/j.ejphar.2011.02.016. Epub 2011 Mar 1.


HE3286: a novel synthetic steroid as an oral treatment for autoimmune disease.

Ahlem C, Auci D, Mangano K, Reading C, Frincke J, Stickney D, Nicoletti F.

Ann N Y Acad Sci. 2009 Sep;1173:781-90. doi: 10.1111/j.1749-6632.2009.04798.x.


HE3286 reduces axonal loss and preserves retinal ganglion cell function in experimental optic neuritis.

Khan RS, Dine K, Luna E, Ahlem C, Shindler KS.

Invest Ophthalmol Vis Sci. 2014 Aug 19;55(9):5744-51. doi: 10.1167/iovs.14-14672.


A synthetic anti-inflammatory sterol improves insulin sensitivity in insulin-resistant obese impaired glucose tolerance subjects.

Reading CL, Stickney DR, Flores-Riveros J, Destiche DA, Ahlem CN, Cefalu WT, Frincke JM.

Obesity (Silver Spring). 2013 Sep;21(9):E343-9. doi: 10.1002/oby.20207. Epub 2013 May 13.


Pharmacology and immune modulating properties of 5-androstene-3β,7β,17β-triol, a DHEA metabolite in the human metabolome.

Ahlem CN, Auci DL, Nicoletti F, Pieters R, Kennedy MR, Page TM, Reading CL, Enioutina EY, Frincke JM.

J Steroid Biochem Mol Biol. 2011 Sep;126(3-5):87-94. doi: 10.1016/j.jsbmb.2011.04.010. Epub 2011 May 5.


Oral treatment with HE3286 ameliorates disease in rodent models of rheumatoid arthritis.

Auci DL, Mangano K, Destiche D, White SK, Huang Y, Boyle D, Frincke J, Reading CL, Nicoletti F.

Int J Mol Med. 2010 Apr;25(4):625-33.


HE3286, an oral synthetic steroid, treats lung inflammation in mice without immune suppression.

Conrad D, Wang A, Pieters R, Nicoletti F, Mangano K, van Heeckeren AM, White SK, Frincke JM, Reading CL, Stickney D, Auci DL.

J Inflamm (Lond). 2010 Oct 30;7:52. doi: 10.1186/1476-9255-7-52.


The anti-tumor effects of androstene steroids exhibit a strict structure-activity relationship dependent upon the orientation of the hydroxyl group on carbon-17.

Graf MR, Jia W, Lewbart ML, Loria RM.

Chem Biol Drug Des. 2009 Dec;74(6):625-9. doi: 10.1111/j.1747-0285.2009.00900.x. Epub 2009 Oct 12.


A potential role for 5-androstene-3β,7β,17β-triol in obesity and metabolic syndrome.

Auci DL, Ahlem CN, Kennedy MR, Page TM, Reading CL, Frincke JM.

Obesity (Silver Spring). 2011 Apr;19(4):806-11. doi: 10.1038/oby.2010.204. Epub 2010 Sep 16.


5-Androstene-3β,7β,17β-triol (β-AET) slows thermal injury induced osteopenia in mice: relation to aging and osteoporosis.

Malik AK, Khaldoyanidi S, Auci DL, Miller SC, Ahlem CN, Reading CL, Page T, Frincke JM.

PLoS One. 2010 Oct 21;5(10):e13566. doi: 10.1371/journal.pone.0013566.


17α-Ethynyl-androst-5-ene-3β,7β,17β-triol (HE3286) Is Neuroprotective and Reduces Motor Impairment and Neuroinflammation in a Murine MPTP Model of Parkinson's Disease.

Nicoletti F, Philippens I, Fagone P, Ahlem CN, Reading CL, Frincke JM, Auci DL.

Parkinsons Dis. 2012;2012:969418. doi: 10.1155/2012/969418. Epub 2012 Sep 26.


7-Hydroxylated derivatives of dehydroepiandrosterone in the human ventricular cerebrospinal fluid.

Starka L, Hill M, Kancheva R, Novak Z, Chrastina J, Pohanka M, Morfin R.

Neuro Endocrinol Lett. 2009;30(3):368-72.


A new antidiabetic compound attenuates inflammation and insulin resistance in Zucker diabetic fatty rats.

Lu M, Patsouris D, Li P, Flores-Riveros J, Frincke JM, Watkins S, Schenk S, Olefsky JM.

Am J Physiol Endocrinol Metab. 2010 May;298(5):E1036-48. doi: 10.1152/ajpendo.00668.2009. Epub 2010 Feb 16.


In vitro metabolism of dehydroepiandrosterone (DHEA) to 7alpha-hydroxy-DHEA and Delta5-androstene-3beta,17beta-diol in specific regions of the aging brain from Alzheimer's and non-demented patients.

Weill-Engerer S, David JP, Sazdovitch V, Liere P, Schumacher M, Delacourte A, Baulieu EE, Akwa Y.

Brain Res. 2003 Apr 18;969(1-2):117-25.


Binding characteristics of [3H]delta(5)-androstene-3beta,17beta-diol to a nuclear protein in the rabbit vagina.

Traish AM, Huang YH, Min K, Kim NN, Munarriz R, Goldstein I.

Steroids. 2004 Jan;69(1):71-8.


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