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Mutually exclusive binding of telomerase RNA and DNA by Ku alters telomerase recruitment model.

Pfingsten JS, Goodrich KJ, Taabazuing C, Ouenzar F, Chartrand P, Cech TR.

Cell. 2012 Mar 2;148(5):922-32. doi: 10.1016/j.cell.2012.01.033. Epub 2012 Feb 23.


Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends.

Stellwagen AE, Haimberger ZW, Veatch JR, Gottschling DE.

Genes Dev. 2003 Oct 1;17(19):2384-95. Epub 2003 Sep 15.


Ku must load directly onto the chromosome end in order to mediate its telomeric functions.

Lopez CR, Ribes-Zamora A, Indiviglio SM, Williams CL, Haricharan S, Bertuch AA.

PLoS Genet. 2011 Aug;7(8):e1002233. doi: 10.1371/journal.pgen.1002233. Epub 2011 Aug 11.


The principal role of Ku in telomere length maintenance is promotion of Est1 association with telomeres.

Williams JM, Ouenzar F, Lemon LD, Chartrand P, Bertuch AA.

Genetics. 2014 Aug;197(4):1123-36. doi: 10.1534/genetics.114.164707. Epub 2014 May 30.


Ku can contribute to telomere lengthening in yeast at multiple positions in the telomerase RNP.

Zappulla DC, Goodrich KJ, Arthur JR, Gurski LA, Denham EM, Stellwagen AE, Cech TR.

RNA. 2011 Feb;17(2):298-311. doi: 10.1261/rna.2483611. Epub 2010 Dec 21.


RNA recognition by the DNA end-binding Ku heterodimer.

Dalby AB, Goodrich KJ, Pfingsten JS, Cech TR.

RNA. 2013 Jun;19(6):841-51. doi: 10.1261/rna.038703.113. Epub 2013 Apr 22.


The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku.

Peterson SE, Stellwagen AE, Diede SJ, Singer MS, Haimberger ZW, Johnson CO, Tzoneva M, Gottschling DE.

Nat Genet. 2001 Jan;27(1):64-7.


Cell cycle-dependent regulation of yeast telomerase by Ku.

Fisher TS, Taggart AK, Zakian VA.

Nat Struct Mol Biol. 2004 Dec;11(12):1198-205. Epub 2004 Nov 7.


A miniature yeast telomerase RNA functions in vivo and reconstitutes activity in vitro.

Zappulla DC, Goodrich K, Cech TR.

Nat Struct Mol Biol. 2005 Dec;12(12):1072-7. Epub 2005 Nov 20. Erratum in: Nat Struct Mol Biol. 2006 May;13(5):465.


Distinct faces of the Ku heterodimer mediate DNA repair and telomeric functions.

Ribes-Zamora A, Mihalek I, Lichtarge O, Bertuch AA.

Nat Struct Mol Biol. 2007 Apr;14(4):301-7. Epub 2007 Mar 11.


Human Ku70/80 associates physically with telomerase through interaction with hTERT.

Chai W, Ford LP, Lenertz L, Wright WE, Shay JW.

J Biol Chem. 2002 Dec 6;277(49):47242-7. Epub 2002 Oct 10.


Altering telomere structure allows telomerase to act in yeast lacking ATM kinases.

Chan SW, Chang J, Prescott J, Blackburn EH.

Curr Biol. 2001 Aug 21;11(16):1240-50.


TRF2 interaction with Ku heterotetramerization interface gives insight into c-NHEJ prevention at human telomeres.

Ribes-Zamora A, Indiviglio SM, Mihalek I, Williams CL, Bertuch AA.

Cell Rep. 2013 Oct 17;5(1):194-206. doi: 10.1016/j.celrep.2013.08.040. Epub 2013 Oct 3.


Est1 has the properties of a single-stranded telomere end-binding protein.

Virta-Pearlman V, Morris DK, Lundblad V.

Genes Dev. 1996 Dec 15;10(24):3094-104.


Telomere maintenance is dependent on activities required for end repair of double-strand breaks.

Nugent CI, Bosco G, Ross LO, Evans SK, Salinger AP, Moore JK, Haber JE, Lundblad V.

Curr Biol. 1998 May 21;8(11):657-60.


Sequential loading of Saccharomyces cerevisiae Ku and Cdc13p to telomeres.

Wu TJ, Chiang YH, Lin YC, Tsai CR, Yu TY, Sung MT, Lee YH, Lin JJ.

J Biol Chem. 2009 May 8;284(19):12801-8. doi: 10.1074/jbc.M809131200. Epub 2009 Mar 9.

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