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Items: 1 to 20 of 100

1.

Phosphoramidate prodrugs of (-)-β-D-(2R,4R)-dioxolane-thymine (DOT) as potent anti-HIV agents.

Wang P, Rachakonda S, Zennou V, Keilman M, Niu C, Bao D, Ross BS, Furman PA, Otto MJ, Sofia MJ.

Antivir Chem Chemother. 2012 May 14;22(5):217-38. doi: 10.3851/IMP2079.

PMID:
22358223
2.

Phosphoramidate and phosphate prodrugs of (-)-beta-D-(2R,4R)-dioxolane-thymine: synthesis, anti-HIV activity and stability studies.

Liang Y, Narayanasamy J, Schinazi RF, Chu CK.

Bioorg Med Chem. 2006 Apr 1;14(7):2178-89. Epub 2005 Nov 28.

PMID:
16314108
3.

5'-O-Aliphatic and amino acid ester prodrugs of (-)-beta-D-(2R,4R)-dioxolane-thymine (DOT): synthesis, anti-HIV activity, cytotoxicity and stability studies.

Liang Y, Sharon A, Grier JP, Rapp KL, Schinazi RF, Chu CK.

Bioorg Med Chem. 2009 Feb 1;17(3):1404-9. doi: 10.1016/j.bmc.2008.10.078. Epub 2008 Nov 5.

PMID:
19153047
4.

PAMAM dendrimers and branched polyethyleneglycol (nanoparticles) prodrugs of (-)-beta-D-(2R, 4R)-dioxolane-thymine (DOT) and their anti-HIV activity.

Liang Y, Narayanasamy J, Rapp KL, Schinazi RF, Chu CK.

Antivir Chem Chemother. 2006;17(6):321-9.

PMID:
17249246
5.

Synthesis and anti-HIV activity of (-)-beta-D-(2R,4R)-1,3-dioxolane-2,6-diamino purine (DAPD) (amdoxovir) and (-)-beta-D-(2R,4R)-1,3-dioxolane guanosine (DXG) prodrugs.

Narayanasamy J, Pullagurla MR, Sharon A, Wang J, Schinazi RF, Chu CK.

Antiviral Res. 2007 Sep;75(3):198-209. Epub 2007 Mar 30.

6.

Synthesis and antiviral evaluation of 2-amino-6-carbamoylpurine dioxolane nucleoside derivatives and their phosphoramidates prodrugs.

Cho JH, Bondana L, Detorio MA, Montero C, Bassit LC, Amblard F, Coats SJ, Schinazi RF.

Bioorg Med Chem. 2014 Dec 1;22(23):6665-6671. doi: 10.1016/j.bmc.2014.10.003. Epub 2014 Oct 13.

7.

Design and synthesis of lipophilic phosphoramidate d4T-MP prodrugs expressing high potency against HIV in cell culture: structural determinants for in vitro activity and QSAR.

Siddiqui AQ, McGuigan C, Ballatore C, Zuccotto F, Gilbert IH, De Clercq E, Balzarini J.

J Med Chem. 1999 Oct 7;42(20):4122-8.

PMID:
10514282
8.

Mechanism of action of (-)-(2R,4R)-1-(2-hydroxymethyl-1,3-dioxolan-4-yl) thymine as an anti-HIV agent.

Murakami E, Bao H, Basavapathruni A, Bailey CM, Du J, Steuer HM, Niu C, Whitaker T, Anderson KS, Otto MJ, Furman PA.

Antivir Chem Chemother. 2007;18(2):83-92.

PMID:
17542153
9.

Synthesis and biological evaluation of a cytarabine phosphoramidate prodrug.

Tobias SC, Borch RF.

Mol Pharm. 2004 Mar-Apr;1(2):112-6.

PMID:
15832507
10.

Synthesis and study of a new series of phosphoramidate derivatives as mononucleotide prodrugs.

Egron D, Périgaud C, Gosselin G, Aubertin AM, Imbach JL.

Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):751-4.

PMID:
11563108
11.

Pharmacokinetics of the anti-human immunodeficiency virus agent 1-(beta-D-dioxolane)thymine in rhesus monkeys.

Asif G, Hurwitz SJ, Obikhod A, Delinsky D, Narayanasamy J, Chu CK, McClure HM, Schinazi RF.

Antimicrob Agents Chemother. 2007 Jul;51(7):2424-9. Epub 2007 May 7.

12.

Phenyl phosphoramidate derivatives of stavudine as anti-HIV agents with potent and selective in-vitro antiviral activity against adenovirus.

Uckun FM, Pendergrass S, Qazi S, Samuel P, Venkatachalam TK.

Eur J Med Chem. 2004 Mar;39(3):225-34.

PMID:
15051170
13.

Synthesis and biological evaluation of L- and D-configuration 1,3-dioxolane 5-azacytosine and 6-azathymine nucleosides.

Luo MZ, Liu MC, Mozdziesz DE, Lin TS, Dutschman GE, Gullen EA, Cheng YC, Sartorelli AC.

Bioorg Med Chem Lett. 2000 Sep 18;10(18):2145-8.

PMID:
10999490
14.
15.

Synthesis and biological evaluation of phosphoramidate prodrugs of two analogues of 2-deoxy-d-ribose-1-phosphate directed to the discovery of two carbasugars as new potential anti-HIV leads.

Hamon N, Slusarczyk M, Serpi M, Balzarini J, McGuigan C.

Bioorg Med Chem. 2015 Feb 15;23(4):829-38. doi: 10.1016/j.bmc.2014.12.039. Epub 2014 Dec 25.

PMID:
25616343
16.

Synthesis and in vitro enzymatic and antiviral evaluation of phosphoramidate d4T derivatives as chain terminators.

Yang S, Pannecouque C, Lescrinier E, Giraut A, Herdewijn P.

Org Biomol Chem. 2012 Jan 7;10(1):146-53. doi: 10.1039/c1ob06214j. Epub 2011 Nov 8.

PMID:
22069085
17.

Synthesis and anti-herpetic activity of phosphoramidate ProTides.

Maiti M, Persoons L, Andrei G, Snoeck R, Balzarini J, Herdewijn P.

ChemMedChem. 2013 Jun;8(6):985-93. doi: 10.1002/cmdc.201300035. Epub 2013 Apr 18.

PMID:
23606629
18.

Phosphoramidate prodrugs deliver with potency against hepatitis C virus.

Mehellou Y.

ChemMedChem. 2010 Nov 8;5(11):1841-2. doi: 10.1002/cmdc.201000310. No abstract available.

PMID:
20865770
19.
20.

Stereospecific chemical and enzymatic stability of phosphoramidate triester prodrugs of d4T in vitro.

Siccardi D, Gumbleton M, Omidi Y, McGuigan C.

Eur J Pharm Sci. 2004 May;22(1):25-31.

PMID:
15113580

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