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Items: 1 to 20 of 91

1.

Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis.

Pareek TK, Belkadi A, Kesavapany S, Zaremba A, Loh SL, Bai L, Cohen ML, Meyer C, Liby KT, Miller RH, Sporn MB, Letterio JJ.

Sci Rep. 2011;1:201. doi: 10.1038/srep00201. Epub 2011 Dec 19.

2.

Astragaloside IV attenuates experimental autoimmune encephalomyelitis of mice by counteracting oxidative stress at multiple levels.

He Y, Du M, Gao Y, Liu H, Wang H, Wu X, Wang Z.

PLoS One. 2013 Oct 4;8(10):e76495. doi: 10.1371/journal.pone.0076495. eCollection 2013.

3.

Natural triterpenes modulate immune-inflammatory markers of experimental autoimmune encephalomyelitis: therapeutic implications for multiple sclerosis.

Martín R, Hernández M, Córdova C, Nieto ML.

Br J Pharmacol. 2012 Jul;166(5):1708-23. doi: 10.1111/j.1476-5381.2012.01869.x.

4.

A novel human truncated IL12rβ1-Fc fusion protein ameliorates experimental autoimmune encephalomyelitis via specific binding of p40 to inhibit Th1 and Th17 cell differentiation.

Guo W, Wang C, Wang X, Luo C, Yu D, Wang Y, Chen Y, Lei W, Gao X, Yao W.

Oncotarget. 2015 Oct 6;6(30):28539-55. doi: 10.18632/oncotarget.5164.

5.

A unique tolerizing dendritic cell phenotype induced by the synthetic triterpenoid CDDO-DFPA (RTA-408) is protective against EAE.

Wei HJ, Pareek TK, Liu Q, Letterio JJ.

Sci Rep. 2017 Aug 29;7(1):9886. doi: 10.1038/s41598-017-06907-4.

6.

The novel Nrf2 inducer TFM-735 ameliorates experimental autoimmune encephalomyelitis in mice.

Higashi C, Kawaji A, Tsuda N, Hayashi M, Saito R, Yagishita Y, Suzuki T, Uruno A, Nakamura M, Nakao K, Furusako S, Yamamoto M.

Eur J Pharmacol. 2017 May 5;802:76-84. doi: 10.1016/j.ejphar.2017.02.044. Epub 2017 Feb 27.

PMID:
28246026
7.

The nod-like receptor, Nlrp12, plays an anti-inflammatory role in experimental autoimmune encephalomyelitis.

Gharagozloo M, Mahvelati TM, Imbeault E, Gris P, Zerif E, Bobbala D, Ilangumaran S, Amrani A, Gris D.

J Neuroinflammation. 2015 Oct 31;12:198. doi: 10.1186/s12974-015-0414-5.

8.

7-Methoxy-(9H-β-Carbolin-1-il)-(E)-1-Propenoic Acid, a β-Carboline Alkaloid From Eurycoma longifolia, Exhibits Anti-Inflammatory Effects by Activating the Nrf2/Heme Oxygenase-1 Pathway.

Nguyen HD, Choo YY, Nguyen TD, Nguyen HN, Chau VM, Lee JH.

J Cell Biochem. 2016 Mar;117(3):659-70. doi: 10.1002/jcb.25315. Epub 2015 Sep 3.

PMID:
26291957
9.

Liver X receptor agonist regulation of Th17 lymphocyte function in autoimmunity.

Xu J, Wagoner G, Douglas JC, Drew PD.

J Leukoc Biol. 2009 Aug;86(2):401-9. doi: 10.1189/jlb.1008600.

10.
11.

Ulinastatin attenuates experimental autoimmune encephalomyelitis by enhancing anti-inflammatory responses.

Feng M, Shu Y, Yang Y, Zheng X, Li R, Wang Y, Dai Y, Qiu W, Lu Z, Hu X.

Neurochem Int. 2014 Jan;64:64-72. doi: 10.1016/j.neuint.2013.11.007. Epub 2013 Nov 22.

PMID:
24274996
12.

Spiranthes sinensis Suppresses Production of Pro-Inflammatory Mediators by Down-Regulating the NF-κB Signaling Pathway and Up-Regulating HO-1/Nrf2 Anti-Oxidant Protein.

Shie PH, Huang SS, Deng JS, Huang GJ.

Am J Chin Med. 2015;43(5):969-89. doi: 10.1142/S0192415X15500561. Epub 2015 Jul 30.

PMID:
26224027
13.
14.

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway.

Linker RA, Lee DH, Ryan S, van Dam AM, Conrad R, Bista P, Zeng W, Hronowsky X, Buko A, Chollate S, Ellrichmann G, Brück W, Dawson K, Goelz S, Wiese S, Scannevin RH, Lukashev M, Gold R.

Brain. 2011 Mar;134(Pt 3):678-92. doi: 10.1093/brain/awq386.

PMID:
21354971
15.

CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes.

Reisman SA, Buckley DB, Tanaka Y, Klaassen CD.

Toxicol Appl Pharmacol. 2009 Apr 1;236(1):109-14. doi: 10.1016/j.taap.2008.12.024. Epub 2009 Jan 20.

16.

The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling.

Liby K, Hock T, Yore MM, Suh N, Place AE, Risingsong R, Williams CR, Royce DB, Honda T, Honda Y, Gribble GW, Hill-Kapturczak N, Agarwal A, Sporn MB.

Cancer Res. 2005 Jun 1;65(11):4789-98.

17.

Synthetic triterpenoids attenuate cytotoxic retinal injury: cross-talk between Nrf2 and PI3K/AKT signaling through inhibition of the lipid phosphatase PTEN.

Pitha-Rowe I, Liby K, Royce D, Sporn M.

Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5339-47. doi: 10.1167/iovs.09-3648. Epub 2009 Jun 3.

PMID:
19494206
18.

Esculentoside A Attenuates Allergic Airway Inflammation via Activation of the Nrf-2 Pathway.

Ci X, Zhong W, Ren H, Wen Z, Li D, Peng L.

Int Arch Allergy Immunol. 2015;167(4):280-90. doi: 10.1159/000441061. Epub 2015 Oct 24.

19.

Acute treatment with valproic acid and l-thyroxine ameliorates clinical signs of experimental autoimmune encephalomyelitis and prevents brain pathology in DA rats.

Castelo-Branco G, Stridh P, Guerreiro-Cacais AO, Adzemovic MZ, Falcão AM, Marta M, Berglund R, Gillett A, Hamza KH, Lassmann H, Hermanson O, Jagodic M.

Neurobiol Dis. 2014 Nov;71:220-33. doi: 10.1016/j.nbd.2014.08.019. Epub 2014 Aug 19.

20.

Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1beta, TNF-alpha and IL-6 in an in-vitro model of brain inflammation.

Wilms H, Sievers J, Rickert U, Rostami-Yazdi M, Mrowietz U, Lucius R.

J Neuroinflammation. 2010 May 19;7:30. doi: 10.1186/1742-2094-7-30.

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