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Items: 1 to 20 of 117


Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling after Serca2 knockout.

Swift F, Franzini-Armstrong C, Øyehaug L, Enger UH, Andersson KB, Christensen G, Sejersted OM, Louch WE.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3997-4001. doi: 10.1073/pnas.1120172109. Epub 2012 Feb 21.


Calcium dynamics in the ventricular myocytes of SERCA2 knockout mice: A modeling study.

Li L, Louch WE, Niederer SA, Andersson KB, Christensen G, Sejersted OM, Smith NP.

Biophys J. 2011 Jan 19;100(2):322-31. doi: 10.1016/j.bpj.2010.11.048.


Sodium accumulation promotes diastolic dysfunction in end-stage heart failure following Serca2 knockout.

Louch WE, Hougen K, Mørk HK, Swift F, Aronsen JM, Sjaastad I, Reims HM, Roald B, Andersson KB, Christensen G, Sejersted OM.

J Physiol. 2010 Feb 1;588(Pt 3):465-78. doi: 10.1113/jphysiol.2009.183517. Epub 2009 Dec 14.


Synchrony of cardiomyocyte Ca(2+) release is controlled by T-tubule organization, SR Ca(2+) content, and ryanodine receptor Ca(2+) sensitivity.

Øyehaug L, Loose KØ, Jølle GF, Røe ÅT, Sjaastad I, Christensen G, Sejersted OM, Louch WE.

Biophys J. 2013 Apr 16;104(8):1685-97. doi: 10.1016/j.bpj.2013.03.022.


Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes.

Stokke MK, Hougen K, Sjaastad I, Louch WE, Briston SJ, Enger UH, Andersson KB, Christensen G, Eisner DA, Sejersted OM, Trafford AW.

Cardiovasc Res. 2010 Apr 1;86(1):63-71. doi: 10.1093/cvr/cvp401. Epub 2009 Dec 17.


Depletion of T-tubules and specific subcellular changes in sarcolemmal proteins in tachycardia-induced heart failure.

Balijepalli RC, Lokuta AJ, Maertz NA, Buck JM, Haworth RA, Valdivia HH, Kamp TJ.

Cardiovasc Res. 2003 Jul 1;59(1):67-77.


Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene.

Andersson KB, Birkeland JA, Finsen AV, Louch WE, Sjaastad I, Wang Y, Chen J, Molkentin JD, Chien KR, Sejersted OM, Christensen G.

J Mol Cell Cardiol. 2009 Aug;47(2):180-7. doi: 10.1016/j.yjmcc.2009.03.013. Epub 2009 Mar 26.


Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice.

Zhang T, Guo T, Mishra S, Dalton ND, Kranias EG, Peterson KL, Bers DM, Brown JH.

Circ Res. 2010 Feb 5;106(2):354-62. doi: 10.1161/CIRCRESAHA.109.207423. Epub 2009 Dec 3.


Sarcoplasmic reticulum Ca(2+) atpase (SERCA) 1a structurally substitutes for SERCA2a in the cardiac sarcoplasmic reticulum and increases cardiac Ca(2+) handling capacity.

Lalli MJ, Yong J, Prasad V, Hashimoto K, Plank D, Babu GJ, Kirkpatrick D, Walsh RA, Sussman M, Yatani A, Marbán E, Periasamy M.

Circ Res. 2001 Jul 20;89(2):160-7.


Adiponectin regulates SR Ca(2+) cycling following ischemia/reperfusion via sphingosine 1-phosphate-CaMKII signaling in mice.

Yan W, Zhang F, Zhang R, Zhang X, Wang Y, Zhou F, Xia Y, Liu P, Gao C, Wang H, Zhang L, Zhou J, Gao F, Gao E, Koch WJ, Wang H, Cheng H, Qu Y, Tao L.

J Mol Cell Cardiol. 2014 Sep;74:183-92. doi: 10.1016/j.yjmcc.2014.05.010. Epub 2014 May 20.


CaMKIIδC slows [Ca]i decline in cardiac myocytes by promoting Ca sparks.

Guo T, Zhang T, Ginsburg KS, Mishra S, Brown JH, Bers DM.

Biophys J. 2012 Jun 6;102(11):2461-70. doi: 10.1016/j.bpj.2012.04.015. Epub 2012 Jun 5.


Cardiomyocyte-specific disruption of Serca2 in adult mice causes sarco(endo)plasmic reticulum stress and apoptosis.

Liu XH, Zhang ZY, Andersson KB, Husberg C, Enger UH, Ræder MG, Christensen G, Louch WE.

Cell Calcium. 2011 Apr;49(4):201-7. doi: 10.1016/j.ceca.2010.09.009. Epub 2010 Oct 20.


Sarcoplasmic reticulum Ca2+ cycling protein phosphorylation in a physiologic Ca2+ milieu unleashes a high-power, rhythmic Ca2+ clock in ventricular myocytes: relevance to arrhythmias and bio-pacemaker design.

Sirenko S, Maltsev VA, Maltseva LA, Yang D, Lukyanenko Y, Vinogradova TM, Jones LR, Lakatta EG.

J Mol Cell Cardiol. 2014 Jan;66:106-15. doi: 10.1016/j.yjmcc.2013.11.011. Epub 2013 Nov 22.


Cardiac G-protein-coupled receptor kinase 2 ablation induces a novel Ca2+ handling phenotype resistant to adverse alterations and remodeling after myocardial infarction.

Raake PW, Zhang X, Vinge LE, Brinks H, Gao E, Jaleel N, Li Y, Tang M, Most P, Dorn GW 2nd, Houser SR, Katus HA, Chen X, Koch WJ.

Circulation. 2012 May 1;125(17):2108-18. doi: 10.1161/CIRCULATIONAHA.111.044255. Epub 2012 Apr 10.


Ultrastructural and functional remodeling of the coupling between Ca2+ influx and sarcoplasmic reticulum Ca2+ release in right atrial myocytes from experimental persistent atrial fibrillation.

Lenaerts I, Bito V, Heinzel FR, Driesen RB, Holemans P, D'hooge J, Heidbüchel H, Sipido KR, Willems R.

Circ Res. 2009 Oct 23;105(9):876-85. doi: 10.1161/CIRCRESAHA.109.206276. Epub 2009 Sep 17.


SERCA Cys674 sulphonylation and inhibition of L-type Ca2+ influx contribute to cardiac dysfunction in endotoxemic mice, independent of cGMP synthesis.

Hobai IA, Buys ES, Morse JC, Edgecomb J, Weiss EH, Armoundas AA, Hou X, Khandelwal AR, Siwik DA, Brouckaert P, Cohen RA, Colucci WS.

Am J Physiol Heart Circ Physiol. 2013 Oct 15;305(8):H1189-200. doi: 10.1152/ajpheart.00392.2012. Epub 2013 Aug 9.


Intermittent hypoxia protects cardiomyocytes against ischemia-reperfusion injury-induced alterations in Ca2+ homeostasis and contraction via the sarcoplasmic reticulum and Na+/Ca2+ exchange mechanisms.

Chen L, Lu XY, Li J, Fu JD, Zhou ZN, Yang HT.

Am J Physiol Cell Physiol. 2006 Apr;290(4):C1221-9. Epub 2005 Nov 23. Erratum in: Am J Physiol Cell Physiol. 2006 Nov;291(5):C1099.


CaMKII inhibition targeted to the sarcoplasmic reticulum inhibits frequency-dependent acceleration of relaxation and Ca2+ current facilitation.

Picht E, DeSantiago J, Huke S, Kaetzel MA, Dedman JR, Bers DM.

J Mol Cell Cardiol. 2007 Jan;42(1):196-205. Epub 2006 Oct 17.


Modulation of SR Ca2+ release by the triadin-to-calsequestrin ratio in ventricular myocytes.

Kučerová D, Baba HA, Bokník P, Fabritz L, Heinick A, Mát'uš M, Müller FU, Neumann J, Schmitz W, Kirchhefer U.

Am J Physiol Heart Circ Physiol. 2012 May 15;302(10):H2008-17. doi: 10.1152/ajpheart.00457.2011. Epub 2012 Mar 16.


Targeted ablation of the histidine-rich Ca(2+)-binding protein (HRC) gene is associated with abnormal SR Ca(2+)-cycling and severe pathology under pressure-overload stress.

Park CS, Chen S, Lee H, Cha H, Oh JG, Hong S, Han P, Ginsburg KS, Jin S, Park I, Singh VP, Wang HS, Franzini-Armstrong C, Park WJ, Bers DM, Kranias EG, Cho C, Kim DH.

Basic Res Cardiol. 2013 May;108(3):344. doi: 10.1007/s00395-013-0344-2. Epub 2013 Apr 4.

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