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Caffeic acid phenethyl ester causes p21 induction, Akt signaling reduction, and growth inhibition in PC-3 human prostate cancer cells.

Lin HP, Jiang SS, Chuu CP.

PLoS One. 2012;7(2):e31286. doi: 10.1371/journal.pone.0031286. Epub 2012 Feb 7.


Caffeic acid phenethyl ester induced cell cycle arrest and growth inhibition in androgen-independent prostate cancer cells via regulation of Skp2, p53, p21Cip1 and p27Kip1.

Lin HP, Lin CY, Huo C, Hsiao PH, Su LC, Jiang SS, Chan TM, Chang CH, Chen LT, Kung HJ, Wang HD, Chuu CP.

Oncotarget. 2015 Mar 30;6(9):6684-707.


Caffeic acid phenethyl ester suppresses proliferation and survival of TW2.6 human oral cancer cells via inhibition of Akt signaling.

Kuo YY, Lin HP, Huo C, Su LC, Yang J, Hsiao PH, Chiang HC, Chung CJ, Wang HD, Chang JY, Chen YW, Chuu CP.

Int J Mol Sci. 2013 Apr 24;14(5):8801-17. doi: 10.3390/ijms14058801.


Caffeic acid phenethyl ester as an adjuvant therapy for advanced prostate cancer.

Liu CC, Hsu JM, Kuo LK, Chuu CP.

Med Hypotheses. 2013 May;80(5):617-9. doi: 10.1016/j.mehy.2013.02.003. Epub 2013 Feb 23.


Caffeic acid phenethyl ester synergistically enhances docetaxel and paclitaxel cytotoxicity in prostate cancer cells.

Tolba MF, Esmat A, Al-Abd AM, Azab SS, Khalifa AE, Mosli HA, Abdel-Rahman SZ, Abdel-Naim AB.

IUBMB Life. 2013 Aug;65(8):716-29. doi: 10.1002/iub.1188. Epub 2013 Jul 11.


Caffeic acid phenethyl ester suppresses the proliferation of human prostate cancer cells through inhibition of p70S6K and Akt signaling networks.

Chuu CP, Lin HP, Ciaccio MF, Kokontis JM, Hause RJ Jr, Hiipakka RA, Liao S, Jones RB.

Cancer Prev Res (Phila). 2012 May;5(5):788-97. doi: 10.1158/1940-6207.CAPR-12-0004-T.


Caffeic acid phenethyl ester induces growth arrest and apoptosis of colon cancer cells via the beta-catenin/T-cell factor signaling.

Xiang D, Wang D, He Y, Xie J, Zhong Z, Li Z, Xie J.

Anticancer Drugs. 2006 Aug;17(7):753-62.


Caffeic acid phenethyl ester inhibits nuclear factor-kappaB and protein kinase B signalling pathways and induces caspase-3 expression in primary human CD4+ T cells.

Wang LC, Chu KH, Liang YC, Lin YL, Chiang BL.

Clin Exp Immunol. 2010 May;160(2):223-32. doi: 10.1111/j.1365-2249.2009.04067.x. Epub 2010 Jan 6.


Caffeic acid phenethyl ester induces apoptosis by inhibition of NFkappaB and activation of Fas in human breast cancer MCF-7 cells.

Watabe M, Hishikawa K, Takayanagi A, Shimizu N, Nakaki T.

J Biol Chem. 2004 Feb 13;279(7):6017-26. Epub 2003 Nov 18.


The anticancer mechanism of caffeic acid phenethyl ester (CAPE): review of melanomas, lung and prostate cancers.

Ozturk G, Ginis Z, Akyol S, Erden G, Gurel A, Akyol O.

Eur Rev Med Pharmacol Sci. 2012 Dec;16(15):2064-8. Review.


Inhibitory effect of caffeic acid phenethyl ester on the growth of C6 glioma cells in vitro and in vivo.

Kuo HC, Kuo WH, Lee YJ, Lin WL, Chou FP, Tseng TH.

Cancer Lett. 2006 Mar 28;234(2):199-208.


Antitumor progression potential of caffeic acid phenethyl ester involving p75(NTR) in C6 glioma cells.

Lin WL, Liang WH, Lee YJ, Chuang SK, Tseng TH.

Chem Biol Interact. 2010 Dec 5;188(3):607-15. doi: 10.1016/j.cbi.2010.09.002. Epub 2010 Sep 15.


Inhibition of AMPK-associated autophagy enhances caffeic acid phenethyl ester-induced cell death in C6 glioma cells.

Yu SH, Kao YT, Wu JY, Huang SH, Huang ST, Lee CM, Cheng KT, Lin CM.

Planta Med. 2011 Jun;77(9):907-14. doi: 10.1055/s-0030-1250682. Epub 2011 Jan 17.


CAPE suppresses migration and invasion of prostate cancer cells via activation of non-canonical Wnt signaling.

Tseng JC, Lin CY, Su LC, Fu HH, Yang SD, Chuu CP.

Oncotarget. 2016 Jun 21;7(25):38010-38024. doi: 10.18632/oncotarget.9380.


Caffeic acid phenethyl ester induces E2F-1-mediated growth inhibition and cell-cycle arrest in human cervical cancer cells.

Hsu TH, Chu CC, Hung MW, Lee HJ, Hsu HJ, Chang TC.

FEBS J. 2013 Jun;280(11):2581-93. doi: 10.1111/febs.12242. Epub 2013 Apr 8.


Caffeic acid phenethyl ester inhibits arterial smooth muscle cell proliferation and migration in vitro and in vivo using a local delivery system.

Ho HC, Hsu SL, Ting CT, Kuo CY, Yang VC.

Cell Mol Biol (Noisy-le-grand). 2009 Nov 15;55 Suppl:OL1161-7.


Antiproliferation and radiosensitization of caffeic acid phenethyl ester on human medulloblastoma cells.

Lin YH, Chiu JH, Tseng WS, Wong TT, Chiou SH, Yen SH.

Cancer Chemother Pharmacol. 2006 Apr;57(4):525-32. Epub 2005 Sep 20.


[Impact of NF-kappaB inhibitor on STAT3 translocation in PC-3 prostate cancer cell line].

Li CY, Zhao HX, Zhang X, Chu L, Fang JM, Han H, Liu X, Xu Q.

Zhonghua Nan Ke Xue. 2013 Jun;19(6):487-94. Chinese.


Embelin inhibits growth and induces apoptosis through the suppression of Akt/mTOR/S6K1 signaling cascades.

Kim SW, Kim SM, Bae H, Nam D, Lee JH, Lee SG, Shim BS, Kim SH, Ahn KS, Choi SH, Sethi G, Ahn KS.

Prostate. 2013 Feb 15;73(3):296-305. doi: 10.1002/pros.22574. Epub 2012 Aug 9.


CAPE (caffeic acid phenethyl ester)-based propolis extract (Bio 30) suppresses the growth of human neurofibromatosis (NF) tumor xenografts in mice.

Demestre M, Messerli SM, Celli N, Shahhossini M, Kluwe L, Mautner V, Maruta H.

Phytother Res. 2009 Feb;23(2):226-30. doi: 10.1002/ptr.2594.


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