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Items: 1 to 20 of 118

1.

Synthesis and inhibitory activity of ureidophosphonates, against acetylcholinesterase: pharmacological assay and molecular modeling.

Kaboudin B, Arefi M, Emadi S, Sheikh-Hasani V.

Bioorg Chem. 2012 Apr-Jun;41-42:22-7. doi: 10.1016/j.bioorg.2012.01.003. Epub 2012 Feb 1.

PMID:
22341898
2.

Synthesis of α-oxycarbanilinophosphonates and their anticholinesterase activities: the most potent derivative is bound to the peripheral site of acetylcholinesterase.

Kaboudin B, Emadi S, Faghihi MR, Fallahi M, Sheikh-Hasani V.

J Enzyme Inhib Med Chem. 2013 Jun;28(3):576-82. doi: 10.3109/14756366.2012.663362. Epub 2012 Mar 7.

PMID:
22397393
3.

Design, synthesis and evaluation of flavonoid derivatives as potent AChE inhibitors.

Sheng R, Lin X, Zhang J, Chol KS, Huang W, Yang B, He Q, Hu Y.

Bioorg Med Chem. 2009 Sep 15;17(18):6692-8. doi: 10.1016/j.bmc.2009.07.072. Epub 2009 Aug 3.

PMID:
19692250
4.

Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors.

Huang L, Shi A, He F, Li X.

Bioorg Med Chem. 2010 Feb;18(3):1244-51. doi: 10.1016/j.bmc.2009.12.035. Epub 2009 Dec 16.

PMID:
20056426
5.

1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies.

Di Pietro O, Viayna E, Vicente-García E, Bartolini M, Ramón R, Juárez-Jiménez J, Clos MV, Pérez B, Andrisano V, Luque FJ, Lavilla R, Muñoz-Torrero D.

Eur J Med Chem. 2014 Feb 12;73:141-52. doi: 10.1016/j.ejmech.2013.12.008. Epub 2013 Dec 18.

PMID:
24389509
6.

Synthesis and biological evaluation of novel flavonoid derivatives as dual binding acetylcholinesterase inhibitors.

Shen Y, Zhang J, Sheng R, Dong X, He Q, Yang B, Hu Y.

J Enzyme Inhib Med Chem. 2009 Apr;24(2):372-80. doi: 10.1080/14756360802187885 .

PMID:
18830885
7.

Synthesis and acetylcholinesterase and butyrylcholinesterase inhibitory activities of 7-alkoxyl substituted indolizinoquinoline-5,12-dione derivatives.

Wu ZP, Wu XW, Shen T, Li YP, Cheng X, Gu LQ, Huang ZS, An LK.

Arch Pharm (Weinheim). 2012 Mar;345(3):175-84. doi: 10.1002/ardp.201100188. Epub 2011 Oct 12.

PMID:
21989769
8.

Synthesis, biological assessment and molecular modeling of 14-aryl-10,11,12,14-tetrahydro-9H-benzo[5,6]chromeno[2,3-b]quinolin-13-amines.

Maalej E, Chabchoub F, Samadi A, de los Ríos C, Perona A, Morreale A, Marco-Contelles J.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2384-8. doi: 10.1016/j.bmcl.2011.02.094. Epub 2011 Mar 14.

PMID:
21411323
9.

Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abeta1-42 aggregation for Alzheimer's disease therapeutics.

Kwon YE, Park JY, No KT, Shin JH, Lee SK, Eun JS, Yang JH, Shin TY, Kim DK, Chae BS, Leem JY, Kim KH.

Bioorg Med Chem. 2007 Oct 15;15(20):6596-607. Epub 2007 Jul 25.

PMID:
17681794
10.

Synthesis, biological evaluation and molecular modeling of aloe-emodin derivatives as new acetylcholinesterase inhibitors.

Shi DH, Huang W, Li C, Wang LT, Wang SF.

Bioorg Med Chem. 2013 Mar 1;21(5):1064-73. doi: 10.1016/j.bmc.2013.01.015. Epub 2013 Jan 16.

PMID:
23380475
11.

Design, synthesis and evaluation of novel 2-(aminoalkyl)-isoindoline-1,3-dione derivatives as dual-binding site acetylcholinesterase inhibitors.

Ignasik M, Bajda M, Guzior N, Prinz M, Holzgrabe U, Malawska B.

Arch Pharm (Weinheim). 2012 Jul;345(7):509-16. doi: 10.1002/ardp.201100423. Epub 2012 Mar 30.

PMID:
22467516
12.

Design, synthesis, and biological evaluation of coumarin derivatives tethered to an edrophonium-like fragment as highly potent and selective dual binding site acetylcholinesterase inhibitors.

Pisani L, Catto M, Giangreco I, Leonetti F, Nicolotti O, Stefanachi A, Cellamare S, Carotti A.

ChemMedChem. 2010 Sep 3;5(9):1616-30. doi: 10.1002/cmdc.201000210.

PMID:
20677317
13.

Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.

Belluti F, Bartolini M, Bottegoni G, Bisi A, Cavalli A, Andrisano V, Rampa A.

Eur J Med Chem. 2011 May;46(5):1682-93. doi: 10.1016/j.ejmech.2011.02.019. Epub 2011 Feb 22.

PMID:
21397996
14.

Discovery of dual binding site acetylcholinesterase inhibitors identified by pharmacophore modeling and sequential virtual screening techniques.

Gupta S, Fallarero A, Järvinen P, Karlsson D, Johnson MS, Vuorela PM, Mohan CG.

Bioorg Med Chem Lett. 2011 Feb 15;21(4):1105-12. doi: 10.1016/j.bmcl.2010.12.131. Epub 2011 Jan 1.

PMID:
21273074
15.

4-Aryl-4-oxo-N-phenyl-2-aminylbutyramides as acetyl- and butyrylcholinesterase inhibitors. Preparation, anticholinesterase activity, docking study, and 3D structure-activity relationship based on molecular interaction fields.

Vitorović-Todorović MD, Juranić IO, Mandić LM, Drakulić BJ.

Bioorg Med Chem. 2010 Feb;18(3):1181-93. doi: 10.1016/j.bmc.2009.12.042. Epub 2009 Dec 22.

PMID:
20061157
16.

Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as dual inhibitors for cholinesterases and amyloid beta aggregation.

Luo W, Li YP, He Y, Huang SL, Tan JH, Ou TM, Li D, Gu LQ, Huang ZS.

Bioorg Med Chem. 2011 Jan 15;19(2):763-70. doi: 10.1016/j.bmc.2010.12.022. Epub 2010 Dec 13.

PMID:
21211982
17.

Acetylcholinesterase inhibitors for potential use in Alzheimer's disease: molecular modeling, synthesis and kinetic evaluation of 11H-indeno-[1,2-b]-quinolin-10-ylamine derivatives.

Rampa A, Bisi A, Belluti F, Gobbi S, Valenti P, Andrisano V, Cavrini V, Cavalli A, Recanatini M.

Bioorg Med Chem. 2000 Mar;8(3):497-506.

PMID:
10732965
19.

Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase.

Huang L, Luo Z, He F, Lu J, Li X.

Bioorg Med Chem. 2010 Jun 15;18(12):4475-84. doi: 10.1016/j.bmc.2010.04.063. Epub 2010 Apr 27.

PMID:
20471843
20.

Structure-activity relationships and binding mode in the human acetylcholinesterase active site of pseudo-irreversible inhibitors related to xanthostigmine.

Rizzo S, Cavalli A, Ceccarini L, Bartolini M, Belluti F, Bisi A, Andrisano V, Recanatini M, Rampa A.

ChemMedChem. 2009 Apr;4(4):670-9. doi: 10.1002/cmdc.200800396.

PMID:
19222043

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