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Items: 1 to 20 of 96

1.

Fatty acid synthase modulates intestinal barrier function through palmitoylation of mucin 2.

Wei X, Yang Z, Rey FE, Ridaura VK, Davidson NO, Gordon JI, Semenkovich CF.

Cell Host Microbe. 2012 Feb 16;11(2):140-52. doi: 10.1016/j.chom.2011.12.006.

2.

Probiotic mixture VSL#3 reduces colonic inflammation and improves intestinal barrier function in Muc2 mucin-deficient mice.

Kumar M, Kissoon-Singh V, Coria AL, Moreau F, Chadee K.

Am J Physiol Gastrointest Liver Physiol. 2017 Jan 1;312(1):G34-G45. doi: 10.1152/ajpgi.00298.2016. Epub 2016 Nov 17.

PMID:
27856417
3.

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria.

Johansson ME, Phillipson M, Petersson J, Velcich A, Holm L, Hansson GC.

Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15064-9. doi: 10.1073/pnas.0803124105. Epub 2008 Sep 19.

4.

De novo lipogenesis maintains vascular homeostasis through endothelial nitric-oxide synthase (eNOS) palmitoylation.

Wei X, Schneider JG, Shenouda SM, Lee A, Towler DA, Chakravarthy MV, Vita JA, Semenkovich CF.

J Biol Chem. 2011 Jan 28;286(4):2933-45. doi: 10.1074/jbc.M110.193037. Epub 2010 Nov 23.

5.

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis.

Johansson ME, Gustafsson JK, Holmén-Larsson J, Jabbar KS, Xia L, Xu H, Ghishan FK, Carvalho FA, Gewirtz AT, Sjövall H, Hansson GC.

Gut. 2014 Feb;63(2):281-91. doi: 10.1136/gutjnl-2012-303207. Epub 2013 Feb 20.

6.

Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa.

Bergstrom KS, Kissoon-Singh V, Gibson DL, Ma C, Montero M, Sham HP, Ryz N, Huang T, Velcich A, Finlay BB, Chadee K, Vallance BA.

PLoS Pathog. 2010 May 13;6(5):e1000902. doi: 10.1371/journal.ppat.1000902.

7.

Slc26a3 deficiency is associated with loss of colonic HCO3 (-) secretion, absence of a firm mucus layer and barrier impairment in mice.

Xiao F, Yu Q, Li J, Johansson ME, Singh AK, Xia W, Riederer B, Engelhardt R, Montrose M, Soleimani M, Tian DA, Xu G, Hansson GC, Seidler U.

Acta Physiol (Oxf). 2014 May;211(1):161-75. doi: 10.1111/apha.12220. Epub 2014 Jan 31.

PMID:
24373192
8.

Western diet induces dysbiosis with increased E coli in CEABAC10 mice, alters host barrier function favouring AIEC colonisation.

Martinez-Medina M, Denizot J, Dreux N, Robin F, Billard E, Bonnet R, Darfeuille-Michaud A, Barnich N.

Gut. 2014 Jan;63(1):116-24. doi: 10.1136/gutjnl-2012-304119. Epub 2013 Apr 18.

PMID:
23598352
9.

Delivery of a mucin domain enriched in cysteine residues strengthens the intestinal mucous barrier.

Gouyer V, Dubuquoy L, Robbe-Masselot C, Neut C, Singer E, Plet S, Geboes K, Desreumaux P, Gottrand F, Desseyn JL.

Sci Rep. 2015 May 14;5:9577. doi: 10.1038/srep09577.

10.

Spontaneous colitis in Muc2-deficient mice reflects clinical and cellular features of active ulcerative colitis.

Wenzel UA, Magnusson MK, Rydström A, Jonstrand C, Hengst J, Johansson ME, Velcich A, Öhman L, Strid H, Sjövall H, Hansson GC, Wick MJ.

PLoS One. 2014 Jun 19;9(6):e100217. doi: 10.1371/journal.pone.0100217. eCollection 2014.

11.

The mucin Muc2 limits pathogen burdens and epithelial barrier dysfunction during Salmonella enterica serovar Typhimurium colitis.

Zarepour M, Bhullar K, Montero M, Ma C, Huang T, Velcich A, Xia L, Vallance BA.

Infect Immun. 2013 Oct;81(10):3672-83. doi: 10.1128/IAI.00854-13. Epub 2013 Jul 22.

12.

The membrane-bound mucin Muc1 regulates T helper 17-cell responses and colitis in mice.

Nishida A, Lau CW, Zhang M, Andoh A, Shi HN, Mizoguchi E, Mizoguchi A.

Gastroenterology. 2012 Apr;142(4):865-874.e2. doi: 10.1053/j.gastro.2011.12.036. Epub 2011 Dec 24.

13.

Gut microbiota facilitates dietary heme-induced epithelial hyperproliferation by opening the mucus barrier in colon.

Ijssennagger N, Belzer C, Hooiveld GJ, Dekker J, van Mil SW, Müller M, Kleerebezem M, van der Meer R.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):10038-43. doi: 10.1073/pnas.1507645112. Epub 2015 Jul 27.

14.

Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial Colonization.

Johansson ME, Jakobsson HE, Holmén-Larsson J, Schütte A, Ermund A, Rodríguez-Piñeiro AM, Arike L, Wising C, Svensson F, Bäckhed F, Hansson GC.

Cell Host Microbe. 2015 Nov 11;18(5):582-92. doi: 10.1016/j.chom.2015.10.007. Epub 2015 Oct 29.

15.

Stress disrupts intestinal mucus barrier in rats via mucin O-glycosylation shift: prevention by a probiotic treatment.

Da Silva S, Robbe-Masselot C, Ait-Belgnaoui A, Mancuso A, Mercade-Loubière M, Salvador-Cartier C, Gillet M, Ferrier L, Loubière P, Dague E, Theodorou V, Mercier-Bonin M.

Am J Physiol Gastrointest Liver Physiol. 2014 Aug 15;307(4):G420-9. doi: 10.1152/ajpgi.00290.2013. Epub 2014 Jun 26.

16.

Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent.

Wrzosek L, Miquel S, Noordine ML, Bouet S, Joncquel Chevalier-Curt M, Robert V, Philippe C, Bridonneau C, Cherbuy C, Robbe-Masselot C, Langella P, Thomas M.

BMC Biol. 2013 May 21;11:61. doi: 10.1186/1741-7007-11-61.

17.

White and dark kidney beans reduce colonic mucosal damage and inflammation in response to dextran sodium sulfate.

Monk JM, Zhang CP, Wu W, Zarepoor L, Lu JT, Liu R, Pauls KP, Wood GA, Tsao R, Robinson LE, Power KA.

J Nutr Biochem. 2015 Jul;26(7):752-60. doi: 10.1016/j.jnutbio.2015.02.003. Epub 2015 Mar 21.

PMID:
25841250
18.

Studies of mucus in mouse stomach, small intestine, and colon. III. Gastrointestinal Muc5ac and Muc2 mucin O-glycan patterns reveal a regiospecific distribution.

Holmén Larsson JM, Thomsson KA, Rodríguez-Piñeiro AM, Karlsson H, Hansson GC.

Am J Physiol Gastrointest Liver Physiol. 2013 Sep 1;305(5):G357-63. doi: 10.1152/ajpgi.00048.2013. Epub 2013 Jul 5.

19.

The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged Mice.

Erickson NA, Nyström EE, Mundhenk L, Arike L, Glauben R, Heimesaat MM, Fischer A, Bereswill S, Birchenough GM, Gruber AD, Johansson ME.

PLoS One. 2015 Jul 10;10(7):e0131991. doi: 10.1371/journal.pone.0131991. eCollection 2015.

20.

Combined defects in epithelial and immunoregulatory factors exacerbate the pathogenesis of inflammation: mucin 2-interleukin 10-deficient mice.

van der Sluis M, Bouma J, Vincent A, Velcich A, Carraway KL, Büller HA, Einerhand AW, van Goudoever JB, Van Seuningen I, Renes IB.

Lab Invest. 2008 Jun;88(6):634-42. doi: 10.1038/labinvest.2008.28. Epub 2008 Apr 21.

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