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mTOR and its downstream pathway are activated in the dorsal root ganglion and spinal cord after peripheral inflammation, but not after nerve injury.

Liang L, Tao B, Fan L, Yaster M, Zhang Y, Tao YX.

Brain Res. 2013 Jun 4;1513:17-25. doi: 10.1016/j.brainres.2013.04.003. Epub 2013 Apr 11.


Involvement of the spinal NMDA receptor/PKCγ signaling pathway in the development of bone cancer pain.

Xiaoping G, Xiaofang Z, Yaguo Z, Juan Z, Junhua W, Zhengliang M.

Brain Res. 2010 Jun 4;1335:83-90. doi: 10.1016/j.brainres.2010.03.083. Epub 2010 Apr 1.


Contribution of the spinal cord BDNF to the development of neuropathic pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation.

Geng SJ, Liao FF, Dang WH, Ding X, Liu XD, Cai J, Han JS, Wan Y, Xing GG.

Exp Neurol. 2010 Apr;222(2):256-66. doi: 10.1016/j.expneurol.2010.01.003. Epub 2010 Jan 14.


Mammalian target of rapamycin signaling in the spinal cord is required for neuronal plasticity and behavioral hypersensitivity associated with neuropathy in the rat.

Asante CO, Wallace VC, Dickenson AH.

J Pain. 2010 Dec;11(12):1356-67. doi: 10.1016/j.jpain.2010.03.013. Epub 2010 May 8.


The inhibition of spinal synaptic plasticity mediated by activation of AMP-activated protein kinase signaling alleviates the acute pain induced by oxaliplatin.

Ling YZ, Li ZY, Ou-Yang HD, Ma C, Wu SL, Wei JY, Ding HH, Zhang XL, Liu M, Liu CC, Huang ZZ, Xin WJ.

Exp Neurol. 2017 Feb;288:85-93. doi: 10.1016/j.expneurol.2016.11.009. Epub 2016 Nov 14.


Role of the spinal cord NR2B-containing NMDA receptors in the development of neuropathic pain.

Qu XX, Cai J, Li MJ, Chi YN, Liao FF, Liu FY, Wan Y, Han JS, Xing GG.

Exp Neurol. 2009 Feb;215(2):298-307. doi: 10.1016/j.expneurol.2008.10.018. Epub 2008 Nov 12.


Mammalian target of rapamycin in spinal cord neurons mediates hypersensitivity induced by peripheral inflammation.

Norsted Gregory E, Codeluppi S, Gregory JA, Steinauer J, Svensson CI.

Neuroscience. 2010 Sep 1;169(3):1392-402. doi: 10.1016/j.neuroscience.2010.05.067. Epub 2010 Jun 9.


Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia.

Xu JT, Zhao JY, Zhao X, Ligons D, Tiwari V, Atianjoh FE, Lee CY, Liang L, Zang W, Njoku D, Raja SN, Yaster M, Tao YX.

J Clin Invest. 2014 Feb;124(2):592-603. doi: 10.1172/JCI70236. Epub 2014 Jan 2.


Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia.

Xu Q, Fitzsimmons B, Steinauer J, O'Neill A, Newton AC, Hua XY, Yaksh TL.

J Neurosci. 2011 Feb 9;31(6):2113-24. doi: 10.1523/JNEUROSCI.2139-10.2011.


Intrathecal clonidine suppresses phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit in spinal dorsal horn neurons of rats with neuropathic pain.

Roh DH, Kim HW, Yoon SY, Seo HS, Kwon YB, Han HJ, Beitz AJ, Lee JH.

Anesth Analg. 2008 Aug;107(2):693-700. doi: 10.1213/ane.0b013e31817e7319.


Activation of mTOR in the spinal cord is required for pain hypersensitivity induced by chronic constriction injury in mice.

Zhang W, Sun XF, Bo JH, Zhang J, Liu XJ, Wu LP, Ma ZL, Gu XP.

Pharmacol Biochem Behav. 2013 Oct;111:64-70. doi: 10.1016/j.pbb.2013.07.017. Epub 2013 Aug 12.


Blocking mammalian target of rapamycin alleviates bone cancer pain and morphine tolerance via µ-opioid receptor.

Jiang Z, Wu S, Wu X, Zhong J, Lv A, Jiao J, Chen Z.

Int J Cancer. 2016 Apr 15;138(8):2013-20. doi: 10.1002/ijc.29927. Epub 2015 Dec 8.


Intrathecal administration of the cannabinoid 2 receptor agonist JWH015 can attenuate cancer pain and decrease mRNA expression of the 2B subunit of N-methyl-D-aspartic acid.

Gu X, Mei F, Liu Y, Zhang R, Zhang J, Ma Z.

Anesth Analg. 2011 Aug;113(2):405-11. doi: 10.1213/ANE.0b013e31821d1062. Epub 2011 Apr 25.


Expression and distribution of mTOR, p70S6K, 4E-BP1, and their phosphorylated counterparts in rat dorsal root ganglion and spinal cord dorsal horn.

Xu JT, Zhao X, Yaster M, Tao YX.

Brain Res. 2010 Jun 8;1336:46-57. doi: 10.1016/j.brainres.2010.04.010. Epub 2010 Apr 24.


Brain-derived neurotrophic factor modulates N-methyl-D-aspartate receptor activation in a rat model of cancer-induced bone pain.

Wang LN, Yang JP, Ji FH, Zhan Y, Jin XH, Xu QN, Wang XY, Zuo JL.

J Neurosci Res. 2012 Jun;90(6):1249-60. doi: 10.1002/jnr.22815. Epub 2012 Feb 22.


Spinal cord protein interacting with C kinase 1 is required for the maintenance of complete Freund's adjuvant-induced inflammatory pain but not for incision-induced post-operative pain.

Atianjoh FE, Yaster M, Zhao X, Takamiya K, Xia J, Gauda EB, Huganir RL, Tao YX.

Pain. 2010 Oct;151(1):226-34. doi: 10.1016/j.pain.2010.07.017. Epub 2010 Aug 8.

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