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Distinct roles of secreted HtrA proteases from gram-negative pathogens in cleaving the junctional protein and tumor suppressor E-cadherin.

Hoy B, Geppert T, Boehm M, Reisen F, Plattner P, Gadermaier G, Sewald N, Ferreira F, Briza P, Schneider G, Backert S, Wessler S.

J Biol Chem. 2012 Mar 23;287(13):10115-20. doi: 10.1074/jbc.C111.333419. Epub 2012 Feb 15.


Rapid paracellular transmigration of Campylobacter jejuni across polarized epithelial cells without affecting TER: role of proteolytic-active HtrA cleaving E-cadherin but not fibronectin.

Boehm M, Hoy B, Rohde M, Tegtmeyer N, Bæk KT, Oyarzabal OA, Brøndsted L, Wessler S, Backert S.

Gut Pathog. 2012 Apr 25;4(1):3. doi: 10.1186/1757-4749-4-3.


Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion.

Hoy B, Löwer M, Weydig C, Carra G, Tegtmeyer N, Geppert T, Schröder P, Sewald N, Backert S, Schneider G, Wessler S.

EMBO Rep. 2010 Oct;11(10):798-804. doi: 10.1038/embor.2010.114. Epub 2010 Sep 3.


Prediction of extracellular proteases of the human pathogen Helicobacter pylori reveals proteolytic activity of the Hp1018/19 protein HtrA.

Löwer M, Weydig C, Metzler D, Reuter A, Starzinski-Powitz A, Wessler S, Schneider G.

PLoS One. 2008;3(10):e3510. doi: 10.1371/journal.pone.0003510. Epub 2008 Oct 23.


Degradation by proteases Lon, Clp and HtrA, of Escherichia coli proteins aggregated in vivo by heat shock; HtrA protease action in vivo and in vitro.

Laskowska E, Kuczyńska-Wiśnik D, Skórko-Glonek J, Taylor A.

Mol Microbiol. 1996 Nov;22(3):555-71.


Campylobacter jejuni serine protease HtrA plays an important role in heat tolerance, oxygen resistance, host cell adhesion, invasion, and transmigration.

Boehm M, Lind J, Backert S, Tegtmeyer N.

Eur J Microbiol Immunol (Bp). 2015 Mar;5(1):68-80. doi: 10.1556/EUJMI-D-15-00003. Epub 2015 Mar 26.


The stability and activity of recombinant Helicobacter pylori HtrA under stress conditions.

Hoy B, Brandstetter H, Wessler S.

J Basic Microbiol. 2013 May;53(5):402-9. doi: 10.1002/jobm.201200074. Epub 2012 Jun 26.


HtrA protease family as therapeutic targets.

Skorko-Glonek J, Zurawa-Janicka D, Koper T, Jarzab M, Figaj D, Glaza P, Lipinska B.

Curr Pharm Des. 2013;19(6):977-1009. Review.


The extracellular proteome of Bacillus subtilis under secretion stress conditions.

Antelmann H, Darmon E, Noone D, Veening JW, Westers H, Bron S, Kuipers OP, Devine KM, Hecker M, van Dijl JM.

Mol Microbiol. 2003 Jul;49(1):143-56.


Characterisation of worldwide Helicobacter pylori strains reveals genetic conservation and essentiality of serine protease HtrA.

Tegtmeyer N, Moodley Y, Yamaoka Y, Pernitzsch SR, Schmidt V, Traverso FR, Schmidt TP, Rad R, Yeoh KG, Bow H, Torres J, Gerhard M, Schneider G, Wessler S, Backert S.

Mol Microbiol. 2016 Mar;99(5):925-44. doi: 10.1111/mmi.13276. Epub 2015 Dec 22.


Different contributions of HtrA protease and chaperone activities to Campylobacter jejuni stress tolerance and physiology.

Baek KT, Vegge CS, Skórko-Glonek J, Brøndsted L.

Appl Environ Microbiol. 2011 Jan;77(1):57-66. doi: 10.1128/AEM.01603-10. Epub 2010 Nov 12.


Calcium binding protects E-cadherin from cleavage by Helicobacter pylori HtrA.

Schmidt TP, Goetz C, Huemer M, Schneider G, Wessler S.

Gut Pathog. 2016 Jun 6;8:29. doi: 10.1186/s13099-016-0112-6. eCollection 2016.


Identification of E-cadherin signature motifs functioning as cleavage sites for Helicobacter pylori HtrA.

Schmidt TP, Perna AM, Fugmann T, Böhm M, Jan Hiss, Haller S, Götz C, Tegtmeyer N, Hoy B, Rau TT, Neri D, Backert S, Schneider G, Wessler S.

Sci Rep. 2016 Mar 17;6:23264. doi: 10.1038/srep23264.


The HtrA protease of Campylobacter jejuni is required for heat and oxygen tolerance and for optimal interaction with human epithelial cells.

Brøndsted L, Andersen MT, Parker M, Jørgensen K, Ingmer H.

Appl Environ Microbiol. 2005 Jun;71(6):3205-12.


Recombinant Deg/HtrA proteases from Synechocystis sp. PCC 6803 differ in substrate specificity, biochemical characteristics and mechanism.

Huesgen PF, Miranda H, Lam X, Perthold M, Schuhmann H, Adamska I, Funk C.

Biochem J. 2011 May 1;435(3):733-42. doi: 10.1042/BJ20102131.


Proteolytic inactivation of tissue factor pathway inhibitor by bacterial omptins.

Yun TH, Cott JE, Tapping RI, Slauch JM, Morrissey JH.

Blood. 2009 Jan 29;113(5):1139-48. doi: 10.1182/blood-2008-05-157180. Epub 2008 Nov 6.

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