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Items: 1 to 20 of 338

1.

Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice.

Berglund ED, Vianna CR, Donato J Jr, Kim MH, Chuang JC, Lee CE, Lauzon DA, Lin P, Brule LJ, Scott MM, Coppari R, Elmquist JK.

J Clin Invest. 2012 Mar;122(3):1000-9. doi: 10.1172/JCI59816. Epub 2012 Feb 13.

2.

The roles of leptin receptors on POMC neurons in the regulation of sex-specific energy homeostasis.

Shi H, Sorrell JE, Clegg DJ, Woods SC, Seeley RJ.

Physiol Behav. 2010 May 11;100(2):165-72. doi: 10.1016/j.physbeh.2010.02.018. Epub 2010 Mar 1.

3.

Control of blood pressure, appetite, and glucose by leptin in mice lacking leptin receptors in proopiomelanocortin neurons.

do Carmo JM, da Silva AA, Cai Z, Lin S, Dubinion JH, Hall JE.

Hypertension. 2011 May;57(5):918-26. doi: 10.1161/HYPERTENSIONAHA.110.161349. Epub 2011 Mar 21.

4.

Conditional expression of Pomc in the Lepr-positive subpopulation of POMC neurons is sufficient for normal energy homeostasis and metabolism.

Lam DD, Attard CA, Mercer AJ, Myers MG Jr, Rubinstein M, Low MJ.

Endocrinology. 2015 Apr;156(4):1292-302. doi: 10.1210/en.2014-1373. Epub 2015 Jan 16.

5.

Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility.

Hill JW, Elias CF, Fukuda M, Williams KW, Berglund ED, Holland WL, Cho YR, Chuang JC, Xu Y, Choi M, Lauzon D, Lee CE, Coppari R, Richardson JA, Zigman JM, Chua S, Scherer PE, Lowell BB, Brüning JC, Elmquist JK.

Cell Metab. 2010 Apr 7;11(4):286-97. doi: 10.1016/j.cmet.2010.03.002.

6.

Leptin receptor-positive and leptin receptor-negative proopiomelanocortin neurons innervate an identical set of brain structures.

Lima LB, Metzger M, Furigo IC, Donato J Jr.

Brain Res. 2016 Sep 1;1646:366-376. doi: 10.1016/j.brainres.2016.06.024. Epub 2016 Jun 16.

PMID:
27321158
7.

Disrupted Leptin Signaling in the Lateral Hypothalamus and Ventral Premammillary Nucleus Alters Insulin and Glucagon Secretion and Protects Against Diet-Induced Obesity.

Denroche HC, Glavas MM, Tudurí E, Karunakaran S, Quong WL, Philippe M, Britton HM, Clee SM, Kieffer TJ.

Endocrinology. 2016 Jul;157(7):2671-85. doi: 10.1210/en.2015-1998. Epub 2016 May 16.

PMID:
27183315
8.

Leptin-dependent control of glucose balance and locomotor activity by POMC neurons.

Huo L, Gamber K, Greeley S, Silva J, Huntoon N, Leng XH, Bjørbaek C.

Cell Metab. 2009 Jun;9(6):537-47. doi: 10.1016/j.cmet.2009.05.003.

9.

IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action.

Sadagurski M, Leshan RL, Patterson C, Rozzo A, Kuznetsova A, Skorupski J, Jones JC, Depinho RA, Myers MG Jr, White MF.

Cell Metab. 2012 May 2;15(5):703-12. doi: 10.1016/j.cmet.2012.04.011.

10.

The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity.

Coppari R, Ichinose M, Lee CE, Pullen AE, Kenny CD, McGovern RA, Tang V, Liu SM, Ludwig T, Chua SC Jr, Lowell BB, Elmquist JK.

Cell Metab. 2005 Jan;1(1):63-72.

11.

Loss of leptin receptors on hypothalamic POMC neurons alters synaptic inhibition.

Chun SK, Jo YH.

J Neurophysiol. 2010 Nov;104(5):2321-8. doi: 10.1152/jn.00371.2010. Epub 2010 Sep 15.

12.

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons.

Claret M, Smith MA, Batterham RL, Selman C, Choudhury AI, Fryer LG, Clements M, Al-Qassab H, Heffron H, Xu AW, Speakman JR, Barsh GS, Viollet B, Vaulont S, Ashford ML, Carling D, Withers DJ.

J Clin Invest. 2007 Aug;117(8):2325-36.

13.

Ire1α in Pomc Neurons Is Required for Thermogenesis and Glycemia.

Yao T, Deng Z, Gao Y, Sun J, Kong X, Huang Y, He Z, Xu Y, Chang Y, Yu KJ, Findley BG, Berglund ED, Wang RT, Guo H, Chen H, Li X, Kaufman RJ, Yan J, Liu T, Williams KW.

Diabetes. 2017 Mar;66(3):663-673. doi: 10.2337/db16-0533. Epub 2016 Dec 27.

14.

Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency.

De Jonghe BC, Hayes MR, Zimmer DJ, Kanoski SE, Grill HJ, Bence KK.

Am J Physiol Endocrinol Metab. 2012 Sep 1;303(5):E644-51. doi: 10.1152/ajpendo.00009.2012. Epub 2012 Jul 3.

15.

Rho-kinase regulates energy balance by targeting hypothalamic leptin receptor signaling.

Huang H, Kong D, Byun KH, Ye C, Koda S, Lee DH, Oh BC, Lee SW, Lee B, Zabolotny JM, Kim MS, Bjørbæk C, Lowell BB, Kim YB.

Nat Neurosci. 2012 Oct;15(10):1391-8. doi: 10.1038/nn.3207. Epub 2012 Sep 2.

16.

Shp2 signaling in POMC neurons is important for leptin's actions on blood pressure, energy balance, and glucose regulation.

do Carmo JM, da Silva AA, Ebaady SE, Sessums PO, Abraham RS, Elmquist JK, Lowell BB, Hall JE.

Am J Physiol Regul Integr Comp Physiol. 2014 Dec 15;307(12):R1438-47. doi: 10.1152/ajpregu.00131.2014. Epub 2014 Oct 22.

17.

IL-10 gene transfer upregulates arcuate POMC and ameliorates hyperphagia, obesity and diabetes by substituting for leptin.

Nakata M, Yamamoto S, Okada T, Gantulga D, Okano H, Ozawa K, Yada T.

Int J Obes (Lond). 2016 Mar;40(3):425-33. doi: 10.1038/ijo.2015.201. Epub 2015 Oct 5.

PMID:
26435324
18.

Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion.

van de Wall E, Leshan R, Xu AW, Balthasar N, Coppari R, Liu SM, Jo YH, MacKenzie RG, Allison DB, Dun NJ, Elmquist J, Lowell BB, Barsh GS, de Luca C, Myers MG Jr, Schwartz GJ, Chua SC Jr.

Endocrinology. 2008 Apr;149(4):1773-85. Epub 2007 Dec 27.

19.

Restoration of Lepr in β cells of Lepr null mice does not prevent hyperinsulinemia and hyperglycemia.

D'souza AM, Kieffer TJ.

Mol Metab. 2017 Apr 11;6(6):585-593. doi: 10.1016/j.molmet.2017.04.003. eCollection 2017 Jun.

20.

Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.

Hill JW, Williams KW, Ye C, Luo J, Balthasar N, Coppari R, Cowley MA, Cantley LC, Lowell BB, Elmquist JK.

J Clin Invest. 2008 May;118(5):1796-805. doi: 10.1172/JCI32964.

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