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Structure and allostery of the PKA RIIβ tetrameric holoenzyme.

Zhang P, Smith-Nguyen EV, Keshwani MM, Deal MS, Kornev AP, Taylor SS.

Science. 2012 Feb 10;335(6069):712-6. doi: 10.1126/science.1213979.


The roles of the RIIβ linker and N-terminal cyclic nucleotide-binding domain in determining the unique structures of the type IIβ protein kinase A: a small angle x-ray and neutron scattering study.

Blumenthal DK, Copps J, Smith-Nguyen EV, Zhang P, Heller WT, Taylor SS.

J Biol Chem. 2014 Oct 10;289(41):28505-12. doi: 10.1074/jbc.M114.584177. Epub 2014 Aug 11.


Novel isoform-specific interfaces revealed by PKA RIIbeta holoenzyme structures.

Brown SH, Wu J, Kim C, Alberto K, Taylor SS.

J Mol Biol. 2009 Nov 13;393(5):1070-82. doi: 10.1016/j.jmb.2009.09.014. Epub 2009 Sep 11.


Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme.

Zhang P, Knape MJ, Ahuja LG, Keshwani MM, King CC, Sastri M, Herberg FW, Taylor SS.

PLoS Biol. 2015 Jul 9;13(7):e1002192. doi: 10.1371/journal.pbio.1002192. eCollection 2015 Jul.


Realizing the allosteric potential of the tetrameric protein kinase A RIα holoenzyme.

Boettcher AJ, Wu J, Kim C, Yang J, Bruystens J, Cheung N, Pennypacker JK, Blumenthal DA, Kornev AP, Taylor SS.

Structure. 2011 Feb 9;19(2):265-76. doi: 10.1016/j.str.2010.12.005.


An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes.

Zhang P, Ye F, Bastidas AC, Kornev AP, Wu J, Ginsberg MH, Taylor SS.

Structure. 2015 Sep 1;23(9):1563-72. doi: 10.1016/j.str.2015.07.007. Epub 2015 Aug 13.


The differential response of protein kinase A to cyclic AMP in discrete brain areas correlates with the abundance of regulatory subunit II.

Ventra C, Porcellini A, Feliciello A, Gallo A, Paolillo M, Mele E, Avvedimento VE, Schettini G.

J Neurochem. 1996 Apr;66(4):1752-61.


PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity.

Wu J, Brown SH, von Daake S, Taylor SS.

Science. 2007 Oct 12;318(5848):274-9.


PKA catalytic subunit mutations in adrenocortical Cushing's adenoma impair association with the regulatory subunit.

Calebiro D, Hannawacker A, Lyga S, Bathon K, Zabel U, Ronchi C, Beuschlein F, Reincke M, Lorenz K, Allolio B, Kisker C, Fassnacht M, Lohse MJ.

Nat Commun. 2014 Dec 5;5:5680. doi: 10.1038/ncomms6680.


R-subunit isoform specificity in protein kinase A: distinct features of protein interfaces in PKA types I and II by amide H/2H exchange mass spectrometry.

Anand GS, Hotchko M, Brown SH, Ten Eyck LF, Komives EA, Taylor SS.

J Mol Biol. 2007 Nov 23;374(2):487-99. Epub 2007 Sep 20.


Differential effects of substrate on type I and type II PKA holoenzyme dissociation.

Vigil D, Blumenthal DK, Brown S, Taylor SS, Trewhella J.

Biochemistry. 2004 May 18;43(19):5629-36.


Regulation of cAMP-dependent protein kinases: the human protein kinase X (PrKX) reveals the role of the catalytic subunit alphaH-alphaI loop.

Diskar M, Zenn HM, Kaupisch A, Kaufholz M, Brockmeyer S, Sohmen D, Berrera M, Zaccolo M, Boshart M, Herberg FW, Prinz A.

J Biol Chem. 2010 Nov 12;285(46):35910-8. doi: 10.1074/jbc.M110.155150. Epub 2010 Sep 6.


Localization and quaternary structure of the PKA RIβ holoenzyme.

Ilouz R, Bubis J, Wu J, Yim YY, Deal MS, Kornev AP, Ma Y, Blumenthal DK, Taylor SS.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12443-8. doi: 10.1073/pnas.1209538109. Epub 2012 Jul 13.


Using Markov state models to develop a mechanistic understanding of protein kinase A regulatory subunit RIα activation in response to cAMP binding.

Boras BW, Kornev A, Taylor SS, McCulloch AD.

J Biol Chem. 2014 Oct 24;289(43):30040-51. doi: 10.1074/jbc.M114.568907. Epub 2014 Sep 8.


Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIα.

Akimoto M, McNicholl ET, Ramkissoon A, Moleschi K, Taylor SS, Melacini G.

PLoS Biol. 2015 Nov 30;13(11):e1002305. doi: 10.1371/journal.pbio.1002305. eCollection 2015.


PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation.

Kim C, Cheng CY, Saldanha SA, Taylor SS.

Cell. 2007 Sep 21;130(6):1032-43.

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